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Preparation and Thermosensitivity of Naturally Occurring Polypeptide Poly(γ-glutamic acid) Derivatives Modified by Propyl Groups

Authors

  • Taiki Shimokuri,

    1. Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890-0065, Japan
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  • Tatsuo Kaneko,

    1. Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890-0065, Japan
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  • Takeshi Serizawa,

    1. Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890-0065, Japan
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  • Mitsuru Akashi

    Corresponding author
    1. Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890-0065, Japan
    2. Core Research for Evolution Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo, Japan
    • Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890-0065, Japan. Fax: +(+81) 99 255 1229
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Abstract

Summary: Poly(γ-glutamic acid) (γ-PGA) is a biosynthetic polymer, and the carboxyl groups are able to undergo a chemical modification. In this study, poly(α-propyl γ-glutamate) (γ-PGA propylate) was synthesized by the esterification of these carboxyl groups to yield a thermosensitive and biodegradable polymer. In aqueous solution, the γ-PGA propylate can impart thermosensitivity by controlling the hydrophobic-hydrophilic balance of the γ-PGA polymeric chains.

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Temperature dependence of light transmittance of an aqueous solution of γ-PGA and γ-PGA propylate.

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