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Hydrogel Formation between Enantiomeric B-A-B-Type Block Copolymers of Polylactides (PLLA or PDLA: A) and Polyoxyethylene (PEG: B); PEG-PLLA-PEG and PEG-PDLA-PEG

  1. Takashi Mukose1,
  2. Tomoko Fujiwara1,
  3. Junko Nakano1,
  4. Ikuo Taniguchi1,
  5. Masatoshi Miyamoto2,
  6. Yoshiharu Kimura1,*,
  7. Iwao Teraoka2,
  8. Chan Woo Lee3

Article first published online: 23 MAR 2004

DOI: 10.1002/mabi.200300112

Issue

Macromolecular Bioscience

Macromolecular Bioscience

Special Issue: Highlights from the First IUPAC International Conference on Bio-based Polymers (ICBP 2003) in Saitama, Japan

Volume 4, Issue 3, pages 361–367, March 15, 2004

Additional Information

How to Cite

Mukose, T., Fujiwara, T., Nakano, J., Taniguchi, I., Miyamoto, M., Kimura, Y., Teraoka, I. and Woo Lee, C. (2004), Hydrogel Formation between Enantiomeric B-A-B-Type Block Copolymers of Polylactides (PLLA or PDLA: A) and Polyoxyethylene (PEG: B); PEG-PLLA-PEG and PEG-PDLA-PEG. Macromol. Biosci., 4: 361–367. doi: 10.1002/mabi.200300112

Author Information

  1. 1

    Department Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan

  2. 2

    Herman F. Mark Polymer Research Institute, Polytechnic University, Six MetroTech Center, Brooklyn, NY 11201, USA

  3. 3

    Department of Innovative and Industrial Technology, Hoseo University, Baebang-Myun, Asan, Chungnam 336-795, South Korea

*Department Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan. Fax: +81-75-712-3956

Publication History

  1. Issue published online: 23 MAR 2004
  2. Article first published online: 23 MAR 2004
  3. Manuscript Accepted: 10 FEB 2004
  4. Manuscript Revised: 9 FEB 2004
  5. Manuscript Received: 29 NOV 2003

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Keywords:

  • block copolymers;
  • hydrogels;
  • poly(ethylene glycol);
  • polylactides;
  • stereo-complex

Abstract

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Summary: A mixed suspension of the enantiomeric B-A-B triblock copolymers, polyoxyethylene-block-poly(L-lactide)-block-polyoxyethylene (PEG-PLLA-PEG) and polyoxyethylene-block-poly(D-lactide)-block-polyoxyethylene (PEG-PDLA-PEG), was found to induce reversible gel-to-sol transition depending on the polymer concentration and temperature. The storage and loss moduli of the gel formed at lower temperature were much higher than those of the gel prepared from the corresponding ABA-type triblock copolymers because of the higher polymer concentration in the former. Although the stereo-complexation of the PLLA and PDLA blocks occurred at higher temperature also in the B-A-B copolymers, it was not responsible for the gelation of the mixed suspension. The PEG chains, involved in the helix formation of the PLLA and PDLA, should form helices with opposite helical senses to aggregate and lead the gelation of the system.

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