Get access

Biologically Active Polymers, 6

Authors

  • El-Refaie Kenawy,

    Corresponding author
    1. Department of Chemistry, Polymer Research Group, Faculty of Science, University of Tanta, Tanta, Egypt
    • Department of Chemistry, Polymer Research Group, Faculty of Science, University of Tanta, Tanta, Egypt. Fax: 20 40 3350804
    Search for more papers by this author
  • Yehia A.-G. Mahmoud

    1. Botany Department, Mycology Research Laboratories, Faculty of Science, University of Tanta, Tanta, Egypt
    Search for more papers by this author

  • Part 5: E.-R. Kenawy, F. I. Abdel-Hay, Abd El-Rahem R. El-Shanshoury, M. H. El-Newehy, J. Polym. Sci. Part A: Polym. Chem.2002, 40, 2384–2393.

Abstract

Various copolymers were prepared by the copolymerization of 2-chloroethyl vinyl ether (CEVE) with methyl methacrylate (MMA), hydroxyethyl methacrylate (HEMA) and vinylbenzyl chloride (VBC). The copolymers were further modified by quaternization with triethylamine, triphenylphosphine, and tributylphosphine. The antimicrobial activities of the prepared, quaternized copolymers were evaluated against Candida albicans, Fusarium oxysporium, Aspergillus flavus, Bacillus subtilis, Escherichia coli, and Staphylococcus aureus. The antimicrobial activity was explored by the cut plug method, viable cell counting (surviving ratio), transmission electron microscopy, and potassium leakage tests. The results indicated that the prepared polymers had a high antimicrobial activity, and control experiments on the main polymer without ammonium, phenyl, or butyl and/or phosphonium groups were carried out. The phosphonium containing polycationic biocides are more effective than the quaternary ammonium salt polymers. Examining the C. albicans and S. aureus polymer-treated cells by electron microscopy indicated disruption for the cytoplasmic membrane and release of potassium ion as shown by the assay of potassium leakage.

original image

Growth inhibition of different concentrations of polymer (Xb).

Ancillary