Synthesis of AB Diblock Copolymers by Atom-Transfer Radical Polymerization (ATRP) and Living Polymerization of α-Amino Acid-N-Carboxyanhydrides

Authors

  • Krystyna R. Brzezinska,

    1. Materials Research Laboratory and Materials and Chemistry Departments, University of California, Santa Barbara, Santa Barbara, California 93106
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  • Timothy J. Deming

    Corresponding author
    1. Materials Research Laboratory and Materials and Chemistry Departments, University of California, Santa Barbara, Santa Barbara, California 93106
    • Materials Research Laboratory and Materials and Chemistry Departments, University of California, Santa Barbara, Santa Barbara, California 93106. Fax: (805) 893-7221
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Abstract

Summary: The synthesis of poly(methyl acrylate)-block-poly(γ-benzyl-L-glutamate) (PMA-b-PBLG) diblock copolymers, using atom-transfer radical polymerization (ATRP) of methyl acrylate and living polymerization of γ-benzyl-L-glutamate-N-carboxyanhydride (Glu-NCA) is described. Amido-amidate nickelacycle end groups were incorporated onto amino-terminated poly(methyl acrylates), and the resulting complexes were successfully used as macroinitiators for the growth of polypeptide segments. This method allows the controlled preparation of polypeptide-block-poly(methyl acrylate) diblock architectures with control over polypeptide chain length and without the formation of homopolypeptide contaminants.

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