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Solvent-Assisted Room-Temperature Compression Molding Approach to Fabricate Porous Scaffolds for Tissue Engineering

  1. Dianying Jing1,
  2. Linbo Wu1,2,
  3. Jiandong Ding1,*

Article first published online: 11 SEP 2006

DOI: 10.1002/mabi.200600079

Issue

Macromolecular Bioscience

Macromolecular Bioscience

Volume 6, Issue 9, pages 747–757, September 15, 2006

Additional Information

How to Cite

Jing, D., Wu, L. and Ding, J. (2006), Solvent-Assisted Room-Temperature Compression Molding Approach to Fabricate Porous Scaffolds for Tissue Engineering. Macromol. Biosci., 6: 747–757. doi: 10.1002/mabi.200600079

Author Information

  1. 1

    Key Laboratory of Molecular Engineering of Polymers of Chinese Ministry of Education, Department of Macromolecular Science, Fudan University, Shanghai 200433, China

  2. 2

    State Key Laboratory of Chemical Engineering (Polymer Reaction Engineering Branch), Institute of Polymer Engineering, Zhejiang University, Hangzhou 310027, China

*Key Laboratory of Molecular Engineering of Polymers of Chinese Ministry of Education, Department of Macromolecular Science, Fudan University, Shanghai 200433, China. Fax: +86-21-656-40293

Publication History

  1. Issue published online: 28 SEP 2006
  2. Article first published online: 11 SEP 2006
  3. Manuscript Accepted: 30 MAY 2006
  4. Manuscript Revised: 20 MAY 2006
  5. Manuscript Received: 31 MAR 2006

Funded by

  • NSF of China. Grant Numbers: 20374015, 20304012, 50533010, 20574013
  • Chinese Ministry of Education. Grant Numbers: 305004, 2005CB522700
  • Chinese Ministry of Science and Technology, Science and Technology Development Foundation of Shanghai. Grant Numbers: 04JC14019, 055207082

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Keywords:

  • fabrication;
  • polyesters;
  • porous scaffold;
  • shrinkage;
  • tissue engineering

Abstract

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Summary: This study investigated the room-temperature compression molding/particle leaching approach to fabricate three-dimensional porous scaffolds for tissue engineering. Scaffolds with anatomical shapes (ear, joint, tube, cylinder) were made from biodegradable poly(D,L-lactide) and poly[(D,L-lactide)-co-glycolide]. The utility of this room-temperature compression approach comes from the effect of solvent assistance, but the tendency for post-molding scaffold shrinkage is a problem unique to this method and is thus examined with emphasis in this paper. Scaffold shrinkage was found to be tolerable under normal fabrication conditions with high salt contents, which is just what the preparation of highly porous scaffolds requires. Furthermore, the resultant porosities after salt leaching were measured as well as the initial scaffold shrinkages after solvent evaporation, and the relation between them was revealed by theoretical analysis and confirmed by comparison with experimental measurements. The pores were interconnected, and porosity can exceed 90%. The effects of porosity on the mechanical properties of porous scaffolds were also investigated. This convenient fabrication approach is a prospective method for the tailoring of porous scaffolds for a variety of possible applications in tissue engineering and tissue reconstruction.

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