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Full Paper
Loading and Release of Ibuprofen in Multi- and Monofilament Surgical Sutures
Article first published online: 11 SEP 2006
DOI: 10.1002/mabi.200600084
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Zurita, R., Puiggalí, J. and Rodríguez-Galán, A. (2006), Loading and Release of Ibuprofen in Multi- and Monofilament Surgical Sutures. Macromol. Biosci., 6: 767–775. doi: 10.1002/mabi.200600084
Publication History
- Issue published online: 28 SEP 2006
- Article first published online: 11 SEP 2006
- Manuscript Accepted: 30 MAY 2006
- Manuscript Revised: 23 MAY 2006
- Manuscript Received: 7 APR 2006
Funded by
- CICYT. Grant Number: MAT2003/01004
- FEDER
- Abstract
- Article
- References
- Cited By
Keywords:
- coatings;
- drug delivery;
- ibuprofen polyglycolide;
- poly(p-dioxanone);
- surgical sutures
Abstract
Summary: The preparation of mono- and multifilament sutures incorporating ibuprofen as an anti-inflammatory agent is considered. Poly(p-dioxanone) monofilament samples can be loaded by a molecular diffusion process using a swelling agent such as dichloromethane. The mechanical properties have been measured and have not shown a significant change for the ibuprofen loaded samples in knot tensile assays. The kinetics of both the loading process and the release in a Sörensen's medium at 37 °C have been investigated. Diffusion coefficients have also been estimated from film and slab poly(p-dioxanone) samples containing ibuprofen and their release behavior compared to that shown by monofilaments. Release from a coating copolymer based on lactide, ε-caprolactone and trimethylene carbonate (PLA/PCA/PTMC 10/60/30) has also been studied. This coating solubilizes ibuprofen molecules well and can be used for braided sutures or when a rapid dose of ibuprofen is preferred.