Biomaterials and Biofunctionality in Layered Macromolecular Assemblies

Authors

  • Katsuhiko Ariga,

    Corresponding author
    1. World Premier International (WPI) Research Center for Materials, Nanoarchitectonics (MANA) and Supermolecules Group, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan
    • World Premier International (WPI) Research Center for Materials, Nanoarchitectonics (MANA) and Supermolecules Group, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan. Fax: +81 29 860 4832
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  • Jonathan P. Hill,

    1. World Premier International (WPI) Research Center for Materials, Nanoarchitectonics (MANA) and Supermolecules Group, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan
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  • Qingmin Ji

    1. World Premier International (WPI) Research Center for Materials, Nanoarchitectonics (MANA) and Supermolecules Group, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan
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Abstract

Recent research in the field of LbL assembly is summarized and categorized as fabrication, sensing, drug release/delivery, and cell technology. Special emphasis is given to topics such as cell-membrane-mimic assembly, fabrication of free-standing biomolecular structures including protein microtubes, detection of DNA adducts and reactive metabolites, DNA hybridization analysis, sensing of toxic and bio-active chemicals, entrapment of proteins and DNA, biocomponent carriers with barcode encoding, release and delivery of DNA plasmids, multiagent delivery, smart defense capsules and oxidation-resistant films, vector introduction to cells, patterned cell culturing and microfluidic microreactors, stem cell differentiation, cellular uptake and degradation, and control of cellular apoptosis.

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