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Electrospun Non-Woven Nanofibrous Hybrid Mats Based on Chitosan and PLA for Wound-Dressing Applications

Authors

  • Milena Ignatova,

    1. Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev 103A, 1113 Sofia, Bulgaria
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  • Nevena Manolova,

    1. Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev 103A, 1113 Sofia, Bulgaria
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  • Nadya Markova,

    1. Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev 26, 1113 Sofia, Bulgaria
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  • Iliya Rashkov

    Corresponding author
    1. Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev 103A, 1113 Sofia, Bulgaria
    • Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev 103A, 1113 Sofia, Bulgaria. Fax: +359 2 870 0309
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Abstract

Continuous defect-free nanofibers containing chitosan (Ch) or quaternized chitosan (QCh) were successfully prepared by one-step electrospinning of Ch or QCh solutions mixed with poly[(L-lactide)-co-(d,l-lactide)] in common solvent. XPS revealed the surface chemical composition of the bicomponent electrospun mats. Crosslinked Ch- and QCh-containing nanofibers exhibited higher kill rates against bacteria S. aureus and E. coli than the corresponding solvent-cast films. SEM observations showed that hybrid mats were very effective in suppressing the adhesion of pathogenic bacteria S. aureus. The hybrid nanofibers are promising for wound-healing applications.

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