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Biodegradable Multiblock Copolymers Based on Oligodepsipeptides with Shape-Memory Properties

  1. Yakai Feng2,
  2. Marc Behl1,
  3. Steffen Kelch3,
  4. Andreas Lendlein1,*

Article first published online: 16 DEC 2008

DOI: 10.1002/mabi.200800199

Issue

Macromolecular Bioscience

Macromolecular Bioscience

Volume 9, Issue 1, pages 45–54, January 9, 2009

Additional Information

How to Cite

Feng, Y., Behl, M., Kelch, S. and Lendlein, A. (2009), Biodegradable Multiblock Copolymers Based on Oligodepsipeptides with Shape-Memory Properties. Macromolecular Bioscience, 9: 45–54. doi: 10.1002/mabi.200800199

Author Information

  1. 1

    Centre for Biomaterial Development, Institute of Polymer Research, GKSS Research Centre Geesthacht, Kantstr. 55, 14513 Teltow, Germany

  2. 2

    Department of Polymer Science and Technology, Tianjin University, 92 Weijin Road, Tianjin 300072, China

  3. 3

    Sika Technology AG, Tüffenwies 16, CH-8048 Zürich, Switzerland

*Centre for Biomaterial Development, Institute of Polymer Research, GKSS Research Centre Geesthacht, Kantstr. 55, 14513 Teltow, Germany. Fax: +49 3328 35 2452

Publication History

  1. Issue published online: 22 DEC 2008
  2. Article first published online: 16 DEC 2008
  3. Manuscript Accepted: 9 OCT 2008
  4. Manuscript Revised: 8 OCT 2008
  5. Manuscript Received: 20 JUL 2008

Funded by

  • Bundesministerium für Bildung und Forschung (BMBF)

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Keywords:

  • biodegradable;
  • biomaterials;
  • block copolymers;
  • polydespsipeptides;
  • shape-memory polymers

Abstract

Thermoplastic phase-segregated multiblock copolymers with polydepsipeptides and PCL segments were prepared via coupling of diol and PCL-diol using an aliphatic diisocyanate. The obtained multiblock copolymers showed good elastic properties and a shape memory. Almost complete fixation of the mechanical deformation, resulting in quantitative recovery of the permanent shape with a switching temperature around body temperature, was observed. In hydrolytic degradation experiments, a quick decrease of the molecular weight without induction period was observed, and the material changed from elastic to brittle in 21 d. These materials promise a high potential for biomedical applications such as smart implants or medical devices.

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