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Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin

Authors

  • Lixia Ren,

    1. Beijing National Laboratory for Molecular Science, Division of Polymer Science and Materials, Institute of Chemistry, The Chinese Academy of Science, Beijing 100190, China
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  • Lihong He,

    1. Beijing National Laboratory for Molecular Science, Division of Polymer Science and Materials, Institute of Chemistry, The Chinese Academy of Science, Beijing 100190, China
    2. Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, USA
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  • Tongchen Sun,

    1. Beijing National Laboratory for Molecular Science, Division of Polymer Science and Materials, Institute of Chemistry, The Chinese Academy of Science, Beijing 100190, China
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  • Xia Dong,

    1. Beijing National Laboratory for Molecular Science, Division of Polymer Science and Materials, Institute of Chemistry, The Chinese Academy of Science, Beijing 100190, China
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  • Yongming Chen,

    Corresponding author
    1. Beijing National Laboratory for Molecular Science, Division of Polymer Science and Materials, Institute of Chemistry, The Chinese Academy of Science, Beijing 100190, China
    • Beijing National Laboratory for Molecular Science, Division of Polymer Science and Materials, Institute of Chemistry, The Chinese Academy of Science, Beijing 100190, China.
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  • Jin Huang,

    1. College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China
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  • Chun Wang

    Corresponding author
    1. Department of Biomedical Engineering, University of Minnesota, Minneapolis MN 55455, USA
    • Department of Biomedical Engineering, University of Minnesota, Minneapolis MN 55455, USA.
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Abstract

Novel temperature and pH dual-responsive hydrogels were constructed by inclusion of poly(PEGMA)-co-poly(DMA) with α-cyclodextrin in aqueous solution. The temperature- or pH-induced sol/gel transition in the hydrogels was completely reversible. Studies on structure/property relationships show that chain uniformity, graft density and copolymer concentration affect the hydrogel behavior. A dual-responsive mechanism is proposed. The in vitro release of a model drug from this hydrogel was studied. It was found that the release kinetics were greatly accelerated at higher temperature and at acidic pH conditions, indicating potential applications in controlled drug delivery.

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