Strategies for Zonal Cartilage Repair using Hydrogels

Authors

  • Travis J. Klein,

    1. Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Australia 4059
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  • Simone C. Rizzi,

    1. Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Australia 4059
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  • Johannes C. Reichert,

    1. Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Australia 4059
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  • Nicole Georgi,

    1. Institute for Biomedical Technology, University of Twente, Drienerlolaan 5, 7500 AE Enschede, Twente, The Netherlands
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  • Jos Malda,

    1. Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Australia 4059
    2. Department of Orthopaedics, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
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  • Wouter Schuurman,

    1. Department of Orthopaedics, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    2. Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, 3584CM, Utrecht, The Netherlands
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  • Ross W. Crawford,

    1. Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Australia 4059
    2. Department of Orthopaedics, The Prince Charles Hospital, Rode Rd, Chermside, Australia 4032
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  • Dietmar W. Hutmacher

    Corresponding author
    1. Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Australia 4059
    2. The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Dr, Atlanta GA 30332-0405
    • Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Australia 4059. Fax: (+61) 731 386030
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Abstract

Articular cartilage is a highly hydrated tissue with depth-dependent cellular and matrix properties that provide low-friction load bearing in joints. However, the structure and function are frequently lost and there is insufficient repair response to regenerate high-quality cartilage. Several hydrogel-based tissue-engineering strategies have recently been developed to form constructs with biomimetic zonal variations to improve cartilage repair. Modular hydrogel systems allow for systematic control over hydrogel properties, and advanced fabrication techniques allow for control over construct organization. These technologies have great potential to address many unanswered questions involved in prescribing zonal properties to tissue-engineered constructs for cartilage repair.

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