Highly Efficient “Grafting From” an α-Helical Polypeptide Backbone by Atom Transfer Radical Polymerization

Authors

  • Jianxun Ding,

    1. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    2. Graduate University of the Chinese Academy of Sciences, Beijing 100039, P. R. China
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  • Chunsheng Xiao,

    1. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    2. Graduate University of the Chinese Academy of Sciences, Beijing 100039, P. R. China
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  • Zhaohui Tang,

    1. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
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  • Xiuli Zhuang,

    1. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
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  • Xuesi Chen

    Corresponding author
    1. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    • Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China, Fax: +86 431 85262112.
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Abstract

Because of their favorable biodegradability, biocompatibility, regular secondary structures, and stimuli-responsiveness, synthetic polypeptides have attracted more and more attention in the biomedical material field. In this work, a novel thermo-responsive graft polypeptide, poly(L-glutamate)-graft-poly(2-(2-methoxyethoxy)ethyl methacrylate) (PLG-g-PMEO2MA), is prepared through a combination of ring-opening polymerization and atom transfer radical polymerization. The structure of PLG-g-PMEO2MA is confirmed by FT-IR, 1H NMR, and GPC analyses. The phase transition temperature of PLG-g-PMEO2MA is adjustable by varying the NaCl concentration in aqueous solution. PLG-g-PMEO2MA adopts α-helical conformations both in aqueous solution at 25 and 60 °C and even in the solid state. In addition, PLG-g-PMEO2MA forms stimuli-responsive micelles with an α-helical core and a thermo-responsive shell in water.

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