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Poly(ester urethane) Guides for Peripheral Nerve Regeneration

  1. Valeria Chiono1,2,
  2. Susanna Sartori1,2,
  3. Alfonsina Rechichi1,2,
  4. Chiara Tonda-Turo1,
  5. Giovanni Vozzi2,3,
  6. Federico Vozzi4,5,
  7. Mario D'Acunto2,
  8. Claudia Salvadori6,
  9. Francesca Dini7,
  10. Giovanni Barsotti7,
  11. Fabio Carlucci7,
  12. Silvia Burchielli5,
  13. Silvia Nicolino8,
  14. Chiara Audisio8,
  15. Isabelle Perroteau8,
  16. Paolo Giusti2,3,
  17. Gianluca Ciardelli1,2,*

Article first published online: 22 NOV 2010

DOI: 10.1002/mabi.201000354

Issue

Macromolecular Bioscience

Macromolecular Bioscience

Volume 11, Issue 2, pages 245–256, February 11, 2011

Additional Information

How to Cite

Chiono, V., Sartori, S., Rechichi, A., Tonda-Turo, C., Vozzi, G., Vozzi, F., D'Acunto, M., Salvadori, C., Dini, F., Barsotti, G., Carlucci, F., Burchielli, S., Nicolino, S., Audisio, C., Perroteau, I., Giusti, P. and Ciardelli, G. (2011), Poly(ester urethane) Guides for Peripheral Nerve Regeneration. Macromol. Biosci., 11: 245–256. doi: 10.1002/mabi.201000354

Author Information

  1. 1

    Department of Mechanics, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy

  2. 2

    Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Via Diotisalvi 2, 56126 Pisa, Italy

  3. 3

    C.N.R. Institute for Composite and Biomedical Materials, Via Diotisalvi 2, 56126 Pisa, Italy

  4. 4

    Centro “E. Piaggio”, University of Pisa, Via Diotisalvi 2, 56126 Pisa, Italy

  5. 5

    C.N.R. Institute of Clinical Physiology, Via Moruzzi 1, 56126 Pisa, Italy

  6. 6

    Department of Animal Pathology, Prophylaxis and Hygiene of Aliments, University of Pisa, Via delle Piagge 2, 56126 Pisa, Italy

  7. 7

    Department of Veterinary Clinic, Faculty of Veterinary, University of Pisa, Via Livornese, 56126 Pisa, Italy

  8. 8

    Department of Animal and Human Biology, University of Turin, Via Accademia Albertina 13, 10123 Torino, Italy

*Department of Mechanics, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy Fax: +39 11 56 46999.

Publication History

  1. Issue published online: 31 JAN 2011
  2. Article first published online: 22 NOV 2010
  3. Manuscript Received: 1 SEP 2010

Funded by

  • Bando Programma Neuroscienze – Compagnia San Paolo
  • Bando Ricerca Sanitaria Finalizzata – Regione Piemonte

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Keywords:

  • biological application of polymers;
  • extrusion;
  • melting point;
  • polyurethanes

Abstract

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A biocompatible and elastomeric PU was synthesized from low-molecular-weight PCL as macrodiol, CMD as chain extender and HDI as chain linker for applications in the field of peripheral nerve repair. PU cast films supported in vitro attachment and proliferation of NOBEC. The in vitro adhesion and proliferation of S5Y5 neuroblastoma cells on the inner surface of uncoated, gelatin- and PL-coated PU guides were compared. Due to their superior in vitro performance, PL-coated PU guides were tested in vivo for the repair of 1.8 cm-long defects in rat sciatic nerves. The progressive regeneration was confirmed by EMG and histological analysis showing the presence of regenerating fibers in the distal stumps.

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