Get access

Design of Polyphosphazene Hydrogels with Improved Structural Properties by Use of Star-Shaped Multithiol Crosslinkers

Authors

  • Thrimoorthy Potta,

    1. Division of Life and Health Science, Korean Institute of Science and Technology, Seoul 136-791, Republic of Korea, and Department of Biomolecular Sciences, University of Science and Technology, Daejeon 305-333, Republic of Korea
    Search for more papers by this author
  • ChangJu Chun,

    1. Division of Life and Health Science, Korean Institute of Science and Technology, Seoul 136-791, Republic of Korea
    Search for more papers by this author
  • Soo-Chang Song

    Corresponding author
    1. Division of Life and Health Science, Korean Institute of Science and Technology, Seoul 136-791, Republic of Korea
    • Division of Life and Health Science, Korean Institute of Science and Technology, Seoul 136-791, Republic of Korea.
    Search for more papers by this author

Abstract

The feasibility of using a star-shaped crosslinker to produce a hydrogel with controlled mechanical properties and degradation rates was investigated. The aqueous blends of functional polymers and crosslinkers formed a solution at low temperature and a hydrogel with desired mechanical properties at body temperature. The introduction of star-shaped crosslinkers affected the microscopic and macroscopic properties of the hydrogel. The fabricated hydrogels could be suitable for many potential biomedical applications because of their injectability, tunable mechanical properties, controlled degradation rate and gel formation under physiological conditions.

original image
Get access to the full text of this article

Ancillary