Disulfide Core Cross-Linked PEGylated Polypeptide Nanogel Prepared by a One-Step Ring Opening Copolymerization of N-Carboxyanhydrides for Drug Delivery

Authors

  • Tao Xing,

    1. Hefei National Laboratory for Physical Sciences at the micrometer-scale and Department of Chemical Physics, University of Science and Technology of China. Hefei, 230026, P. R. China
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  • Bin Lai,

    1. Hefei National Laboratory for Physical Sciences at the micrometer-scale and Department of Chemical Physics, University of Science and Technology of China. Hefei, 230026, P. R. China
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  • Xiaodong Ye,

    1. Hefei National Laboratory for Physical Sciences at the micrometer-scale and Department of Chemical Physics, University of Science and Technology of China. Hefei, 230026, P. R. China
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  • Lifeng Yan

    Corresponding author
    1. Hefei National Laboratory for Physical Sciences at the micrometer-scale and Department of Chemical Physics, University of Science and Technology of China. Hefei, 230026, P. R. China
    • Hefei National Laboratory for Physical Sciences at the micrometer-scale and Department of Chemical Physics, University of Science and Technology of China. Hefei, 230026, P. R. China, Fax: +86-551-3606853.
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Abstract

A novel disulfide core cross-linked PEGylated polypeptide nanogel has been synthesized by a one-step ring opening copolymerization of γ-benzyl L-glutamate N-carboxyanhydride and L-cystine N-carboxyanhydride using an amino group-terminated poly(ethylene glycol) methyl ether as initiator. Characterization of products confirms the formation of a core cross-linked PEGylated nanogel with disulfide linkages with a size of about 250 nm, and these studies also confirm that this nanogel can easily be broken by glutathione. Cell viability experiments show the good biocompatibility of the as-prepared polymer. Studies relating to loading and controlled release of indomethacin under reduction-sensitive conditions reveal that the nanogel is a good candidate for drug delivery systems.

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