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Keywords:

  • block copolymers;
  • hydrogels;
  • peptides;
  • telechelics

Abstract

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The self-assembly in aqueous solution of PEG (1 500 Da) telechelically end-capped with hydrophobic dipeptides has been investigated using spectroscopic, microscopic, scattering, and rheological methods. A self-assembled β-sheet fibril-based hydrogel has been identified (containing dityrosine end groups), which exhibits a gel–sol transition near body temperature. This thermo-responsive PEG-based biofunctional hydrogel is expected to have diverse potential uses in delivery or diagnostics for biomedical applications.