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A Thermoresponsive Hydrogel Based on Telechelic PEG End-Capped with Hydrophobic Dipeptides

Authors

  • Ian W. Hamley,

    Corresponding author
    1. Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK
    2. Diamond Light Source, Harwell Science and Innovation Campus, Chilton, Didcot OX11 0DE, UK
    • Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK.
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  • Ge Cheng,

    1. Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK
    2. Diamond Light Source, Harwell Science and Innovation Campus, Chilton, Didcot OX11 0DE, UK
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  • Valeria Castelletto

    1. Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK
    2. Diamond Light Source, Harwell Science and Innovation Campus, Chilton, Didcot OX11 0DE, UK
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Abstract

The self-assembly in aqueous solution of PEG (1 500 Da) telechelically end-capped with hydrophobic dipeptides has been investigated using spectroscopic, microscopic, scattering, and rheological methods. A self-assembled β-sheet fibril-based hydrogel has been identified (containing dityrosine end groups), which exhibits a gel–sol transition near body temperature. This thermo-responsive PEG-based biofunctional hydrogel is expected to have diverse potential uses in delivery or diagnostics for biomedical applications.

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