Get access

Hybrid Polymeric Nanomaterials for siRNA Delivery and Imaging

Authors

  • Hyejung Mok,

    Corresponding author
    1. BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea
    • BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea.
    Search for more papers by this author
  • Tae Gwan Park

    1. BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea
    2. Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea
    Search for more papers by this author

Abstract

A combined nanomaterials-based approach for simultaneous therapy and molecular imaging has powerful potential for efficient treatment and monitoring the prognosis of incurable diseases such as malignant tumors or degenerative diseases. Recent developments of hybrid polymeric nanomaterials for siRNA delivery and imaging are highlighted. A particular focus is on various conjugation and formulation strategies of how to incorporate siRNA and imaging agents onto the surface of functionally active polymer-coated inorganic nanomaterials such as iron oxide, gold, and quantum-dot nanoparticles for theranostic applications. These multifunctional nanocarriers may allow real-time tracking of siRNA as well as visualization of its therapeutic effects in vitro and in vivo.

original image

Ancillary