Fluorescent Micelles Based on Star Amphiphilic Copolymer with a Porphyrin Core for Bioimaging and Drug Delivery

Authors

  • Luzhong Zhang,

    1. Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, P. R. China
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  • Ying Lin,

    1. Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, P. R. China
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  • Yajun Zhang,

    1. Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, P. R. China
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  • Rui Chen,

    1. Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, P. R. China
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  • Zhenshu Zhu,

    1. Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, P. R. China
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  • Wei Wu,

    Corresponding author
    1. Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, P. R. China
    • Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, P. R. China
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  • Xiqun Jiang

    Corresponding author
    1. Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, P. R. China
    • Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, P. R. China
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Abstract

Star-shaped poly(ε-caprolactone)-b-poly(ethylene oxide) amphiphilic copolymer with a tetrakis-(4-aminophenyl)-terminated porphyrin core was synthesized. Paclitaxel (PTX)-loaded polymeric micelles were prepared by the self-assembly of the star copolymer and in situ encapsulation of PTX. The fluorescent characteristic of the porphyrin moiety allowed the cellular uptake and biodistribution of the PTX-loaded micelles to be monitored by fluorescent imaging. The PTX-loaded micelles can be readily internalized by cancer cells and have a slightly higher cytotoxicity than clinic PTX injection Taxol. In vivo real-time fluorescent imaging revealed that the micelles could accumulate at tumor site via the blood circulation in tumor-bearing mice. In vivo antitumor efficacy examinations indicated that the PTX-loaded micelles had significantly superior efficacy in impeding tumor growth than Taxol and low toxicity to the living mice.

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