Combination Self-Assembly of β-Sheet Peptides and Carbon Nanotubes: Functionalizing Carbon Nanotubes with Bioactive β-Sheet Block Copolypeptides

Authors

  • Woo-jin Jeong,

    1. Translational Research Center for Protein Function Control & Department of Materials Science and Engineering, Yonsei University, Seoul, 120-749, Korea
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  • Yong-beom Lim

    Corresponding author
    1. Translational Research Center for Protein Function Control & Department of Materials Science and Engineering, Yonsei University, Seoul, 120-749, Korea
    • Translational Research Center for Protein Function Control & Department of Materials Science and Engineering, Yonsei University, Seoul, 120-749, Korea
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Abstract

Understanding the self-assembly behavior of β-sheet peptides is important, not only in constructing bioactive peptide nanostructures, but also in inhibiting uncontrollable protein aggregation in protein-misfolding diseases. Here, the first systematic investigation of combination self-assembly between β-sheet block copolypeptides and CNTs is presented, demonstrating the presence of several different association modes during the combination self-assembly process. Bioactive β-sheet block copolypeptides can self-assemble by themselves, or can be used to functionalize CNT hybrids depending on the situation. This behavior may be important both for fabricating bioactive peptide/CNT hybrids and for controlling/inhibiting protein-misfolding diseases.

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