Communication

Two-Component In situ Forming Supramolecular Hydrogels as Advanced Biomaterials in Vitreous Body Surgery

  1. Indra Böhm1,
  2. Falko Strotmann2,
  3. Carsten Koopmans1,
  4. Isabel Wolf2,
  5. Hans-Joachim Galla2,
  6. Helmut Ritter1,*

Article first published online: 9 FEB 2012

DOI: 10.1002/mabi.201100357

Issue

Macromolecular Bioscience

Macromolecular Bioscience

Volume 12, Issue 4, pages 432–437, April 2012

Additional Information

How to Cite

Böhm, I., Strotmann, F., Koopmans, C., Wolf, I., Galla, H.-J. and Ritter, H. (2012), Two-Component In situ Forming Supramolecular Hydrogels as Advanced Biomaterials in Vitreous Body Surgery. Macromol. Biosci., 12: 432–437. doi: 10.1002/mabi.201100357

Author Information

  1. 1

    Institute of Organic Chemistry and Macromolecular Chemistry II, Heinrich-Heine-University, Universitätsstraße 1, 40225 Düsseldorf, Germany

  2. 2

    University of Münster, Institute of Biochemistry, Wilhelm-Klemm-Straße 2, 48149 Münster, Germany

*Institute of Organic Chemistry and Macromolecular Chemistry II, Heinrich-Heine-University, Universitätsstraße 1, 40225 Düsseldorf, Germany.

Publication History

  1. Issue published online: 11 APR 2012
  2. Article first published online: 9 FEB 2012
  3. Manuscript Revised: 22 NOV 2011
  4. Manuscript Received: 9 SEP 2011

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Keywords:

  • biocompatibility;
  • cell morphology;
  • cyclodextrin;
  • host–guest hydrogel;
  • membrane interaction;
  • vitreous body

Abstract

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Polymeric β-CD and poly{(2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt)-co-[6-(acrylamido)-N-adamantylhexaneamide]} are synthesized to build in situ forming hydrogels based on host/guest interactions, so called physical hydrogels. The use of these hydrogels as a potential vitreous body substitute is discussed and recommended. Potential changes in cell morphology and cell vitality of the retinal ganglion cell line RGC-5 are determined. DSC experiments with artificial membrane structures are performed. The analyses show that β-CD overrides the harmful effects of the highly toxic adamantyl-modified polymer. Although the final hydrogel is considered to be biocompatible, the application as a biomaterial has to be reconsidered.

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