Full Paper

Preparation of Biodegradable Polylactide Microparticles via a Biocompatible Procedure

  1. Riccardo Levato1,
  2. Miguel A. Mateos-Timoneda1,*,
  3. Josep A. Planell1,2

Article first published online: 23 FEB 2012

DOI: 10.1002/mabi.201100383

Issue

Macromolecular Bioscience

Macromolecular Bioscience

Volume 12, Issue 4, pages 557–566, April 2012

Additional Information

How to Cite

Levato, R., Mateos-Timoneda, M. A. and Planell, J. A. (2012), Preparation of Biodegradable Polylactide Microparticles via a Biocompatible Procedure. Macromol. Biosci., 12: 557–566. doi: 10.1002/mabi.201100383

Author Information

  1. 1

    Institute for Bioengineering of Catalonia (IBEC) and CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Edifici Helix, C/Baldiri Reixac 15-21, 08028 Barcelona, Spain

  2. 2

    Deptartment of Materials Science and Metallurgical Engineering, Technical University of Catalonia, Av. Diagonal 647, 08028 Barcelona, Spain

*Institute for Bioengineering of Catalonia (IBEC) and CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Edifici Helix, C/Baldiri Reixac 15-21, 08028 Barcelona, Spain.

Publication History

  1. Issue published online: 11 APR 2012
  2. Article first published online: 23 FEB 2012
  3. Manuscript Revised: 16 DEC 2011
  4. Manuscript Received: 26 SEP 2011

Funded by

  • MICINN. Grant Number: MAT2009-14195-C03-02
  • VI National R&D&i Plan. Grant Number: 2008-2011

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Keywords:

  • biocompatibility;
  • biodegradable;
  • green solvents;
  • microparticles;
  • poly(lactic acid)

Abstract

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PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 µm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.

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