Get access

Preparation of Biodegradable Polylactide Microparticles via a Biocompatible Procedure

Authors

  • Riccardo Levato,

    1. Institute for Bioengineering of Catalonia (IBEC) and CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Edifici Helix, C/Baldiri Reixac 15-21, 08028 Barcelona, Spain
    Search for more papers by this author
  • Miguel A. Mateos-Timoneda,

    Corresponding author
    1. Institute for Bioengineering of Catalonia (IBEC) and CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Edifici Helix, C/Baldiri Reixac 15-21, 08028 Barcelona, Spain
    • Institute for Bioengineering of Catalonia (IBEC) and CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Edifici Helix, C/Baldiri Reixac 15-21, 08028 Barcelona, Spain.
    Search for more papers by this author
  • Josep A. Planell

    1. Institute for Bioengineering of Catalonia (IBEC) and CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Edifici Helix, C/Baldiri Reixac 15-21, 08028 Barcelona, Spain
    2. Deptartment of Materials Science and Metallurgical Engineering, Technical University of Catalonia, Av. Diagonal 647, 08028 Barcelona, Spain
    Search for more papers by this author

Abstract

PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 µm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.

original image
Get access to the full text of this article

Ancillary