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Protein Conformational Studies for Macromolecularly Imprinted Polymers

Authors

  • David R. Kryscio,

    1. Fletcher Stuckey Pratt Chair in Engineering, Departments of Chemical Engineering and Biomedical Engineering, University of Texas at Austin, 1 University Station C0400, Austin, TX 78712-1062, USA
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  • Michael Q. Fleming,

    1. Fletcher Stuckey Pratt Chair in Engineering, Departments of Chemical Engineering and Biomedical Engineering, University of Texas at Austin, 1 University Station C0400, Austin, TX 78712-1062, USA
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  • Nicholas A. Peppas

    Corresponding author
    1. Fletcher Stuckey Pratt Chair in Engineering, Departments of Chemical Engineering and Biomedical Engineering, University of Texas at Austin, 1 University Station C0400, Austin, TX 78712-1062, USA
    • Fletcher Stuckey Pratt Chair in Engineering, Departments of Chemical Engineering and Biomedical Engineering, University of Texas at Austin, 1 University Station C0400, Austin, TX 78712-1062, USA.
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Abstract

CD is used to clearly show the negative impact of common ligands on the overall conformation of BSA, a typical protein template in macromolecularly imprinted polymers. This change occurs at concentrations far lower than those generally used in the literature. These findings are important as they offer insight into a potential fundamental reason for the lack of success in protein imprinting to date despite significant interest from the scientific community.

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