Doubly Biomimetic Catecholic Phosphorylcholine Copolymer: A Platform Strategy for Fabricating Antifouling Surfaces

Authors

  • Yong-Kuan Gong,

    Corresponding author
    1. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), College of Chemistry and Materials Science, Northwest University, Xi'an 710069, China
    • Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), College of Chemistry and Materials Science, Northwest University, Xi'an 710069, China.
    Search for more papers by this author
  • Li-Ping Liu,

    1. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), College of Chemistry and Materials Science, Northwest University, Xi'an 710069, China
    Search for more papers by this author
  • Phillip B. Messersmith

    Corresponding author
    1. Biomedical Engineering Department and Materials Science and Engineering Department, Northwestern University, Evanston, IL 60208, USA
    • Biomedical Engineering Department and Materials Science and Engineering Department, Northwestern University, Evanston, IL 60208, USA.
    Search for more papers by this author

Abstract

A doubly biomimetic PMNC polymer bearing cell antifouling phosphorylcholine and mussel adhesive protein catechol groups is synthesized. The polymer can be deposited onto a variety of substrates by dip-coating in an aqueous solution, adhering to surfaces via the catechol functional group while at the same time forming a cell outer membrane mimetic antifouling surface. Contact angle, ATR-FTIR and XPS measurements confirm polymer coating formation on a variety of inorganic and organic substrates. BSA and bovine plasma fibrinogen protein adsorption on PMNC coated surfaces are reduced significantly compared to unmodified substrates, and platelet adhesion from human serum onto the PMNC coated substrate surfaces is highly suppressed in this study.

original image

Ancillary