Thermo-Switchable Antibacterial Activity

Authors

  • Claudia Mattheis,

    1. Department of Chemistry and Scientific Center for Materials Science, Philipps-Universität Marburg, Hans-Meerwein-Straße, 35042 Marburg, Germany
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  • Yi Zhang,

    1. Department of Chemistry and Scientific Center for Materials Science, Philipps-Universität Marburg, Hans-Meerwein-Straße, 35042 Marburg, Germany
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  • Seema Agarwal

    Corresponding author
    1. Department of Chemistry and Scientific Center for Materials Science, Philipps-Universität Marburg, Hans-Meerwein-Straße, 35042 Marburg, Germany
    • Department of Chemistry and Scientific Center for Materials Science, Philipps-Universität Marburg, Hans-Meerwein-Straße, 35042 Marburg, Germany
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Abstract

A copolymer system of 2-aminoethyl methacrylate and N-isopropylacrylamide comprises novel properties: changes in conformation and hydrophilicity upon heating influence the antibacterial activity and result in a switchable biocidal effect. The copolymers are characterized via NMR, MALDI-ToF MS, phase transition behavior, and antibacterial tests with E. coli or B. subtilis. MIC and MBC are determined using standard dilution methods, temperature-dependence via incubation at different temperatures and cytotoxicity by MTT tests. The copolymers exhibit lower MIC in globule than coil conformation, crosslinking on cotton results in non-leaching materials with better antibacterial activity above than below the phase-transition point.

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