Permanent Polymer Coating for in vivo MRI Visualization of Tissue Reinforcement Prostheses

Authors

  • Olivier Guillaume,

    1. Max Mousseron Institute of Biomolecules (IBMM), UMR CNRS 5247, University of Montpellier 1, University of Montpellier 2, Faculty of Pharmacy, 15 Av. C. Flahault, Montpellier 34093, France
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  • Sébastien Blanquer,

    1. Max Mousseron Institute of Biomolecules (IBMM), UMR CNRS 5247, University of Montpellier 1, University of Montpellier 2, Faculty of Pharmacy, 15 Av. C. Flahault, Montpellier 34093, France
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  • Vincent Letouzey,

    1. Max Mousseron Institute of Biomolecules (IBMM), UMR CNRS 5247, University of Montpellier 1, University of Montpellier 2, Faculty of Pharmacy, 15 Av. C. Flahault, Montpellier 34093, France
    2. Obstetrics and Gynaecology Department, Caremeau University Hospital, Nîmes 30100, France
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  • Arnaud Cornille,

    1. Max Mousseron Institute of Biomolecules (IBMM), UMR CNRS 5247, University of Montpellier 1, University of Montpellier 2, Faculty of Pharmacy, 15 Av. C. Flahault, Montpellier 34093, France
    2. Obstetrics and Gynaecology Department, Caremeau University Hospital, Nîmes 30100, France
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  • Stephanie Huberlant,

    1. Max Mousseron Institute of Biomolecules (IBMM), UMR CNRS 5247, University of Montpellier 1, University of Montpellier 2, Faculty of Pharmacy, 15 Av. C. Flahault, Montpellier 34093, France
    2. Obstetrics and Gynaecology Department, Caremeau University Hospital, Nîmes 30100, France
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  • Laurent Lemaire,

    1. LUNAM University, UMR-S646, Angers 49933, France
    2. Micro- et Nanomédecines Biomimétiques – MINT, Angers 49933, France
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  • Florence Franconi,

    1. LUNAM University, UMR-S646, Angers 49933, France
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  • Renaud de Tayrac,

    1. Obstetrics and Gynaecology Department, Caremeau University Hospital, Nîmes 30100, France
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  • Jean Coudane,

    1. Max Mousseron Institute of Biomolecules (IBMM), UMR CNRS 5247, University of Montpellier 1, University of Montpellier 2, Faculty of Pharmacy, 15 Av. C. Flahault, Montpellier 34093, France
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  • Xavier Garric

    Corresponding author
    1. Max Mousseron Institute of Biomolecules (IBMM), UMR CNRS 5247, University of Montpellier 1, University of Montpellier 2, Faculty of Pharmacy, 15 Av. C. Flahault, Montpellier 34093, France
    • Max Mousseron Institute of Biomolecules (IBMM), UMR CNRS 5247, University of Montpellier 1, University of Montpellier 2, Faculty of Pharmacy, 15 Av. C. Flahault, Montpellier 34093, France
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Abstract

The clinical advantage of MRI visualization of prostheses in soft tissue prolapses is very appealing as over 1 000 000 MRI-transparent synthetic meshes are implanted annually, and postoperative complications such as mesh shrinkage and migration are frequent. Here, the synthesis of a new material composed of a DTPA-Gd complex grafted onto a backbone of PMA via a covalent bond is described (DTPA-Gd-PMA). This new polymer is sprayed onto meshes and gives an MR signal for a long period without any significant release of Gd. In vitro cytocompatibility tests on fibroblasts show limited cytotoxicity. Microscopic investigations indicate that vital cells rapidly colonize the material. Finally, coated meshes implanted in rats are easily recognizable using an MR imaging system.

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