Full Paper

Scaffold Effects on Osteogenic Differentiation of Equine Mesenchymal Stem Cells: An In Vitro Comparative Study

  1. Rodolfo Nino-Fong1,*,
  2. Laurie A. McDuffee1,
  3. Blanca P. Esparza Gonzalez1,
  4. M. Ramesh Kumar2,
  5. Erika F. Merschrod S.2,
  6. Kristin M. Poduska2,3

Article first published online: 18 JAN 2013

DOI: 10.1002/mabi.201200355

Issue

Macromolecular Bioscience

Macromolecular Bioscience

Volume 13, Issue 3, pages 348–355, March 2013

Additional Information

How to Cite

Nino-Fong, R., McDuffee, L. A., Esparza Gonzalez, B. P., Kumar, M. R., Merschrod S., E. F. and Poduska, K. M. (2013), Scaffold Effects on Osteogenic Differentiation of Equine Mesenchymal Stem Cells: An In Vitro Comparative Study. Macromol. Biosci., 13: 348–355. doi: 10.1002/mabi.201200355

Author Information

  1. 1

    Comparative Orthopaedic Research Laboratory, Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, 550 University Av. Charlottetown, Prince Edward Island, C1A4P3, Canada

  2. 2

    Department of Chemistry, Memorial University, Memorial University St. John's, NL, A1B3X7, Canada

  3. 3

    Department of Physics and Physical Oceanography, Memorial University, St. John's, NL, A1B3X7, Canada

*Comparative Orthopaedic Research Laboratory, Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, 550 University Av. Charlottetown, Prince Edward Island, C1A4P3, Canada

Publication History

  1. Issue published online: 20 MAR 2013
  2. Article first published online: 18 JAN 2013
  3. Manuscript Revised: 14 NOV 2012
  4. Manuscript Received: 9 SEP 2012

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Keywords:

  • biocompatibility;
  • collagen;
  • hydrogels;
  • mesenchymal stem cells;
  • scaffolds

Abstract

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The in vitro viability, osteogenic differentiation, and mineralization of four different equine mesenchymal stem cells (MSCs) from bone marrow, periosteum, muscle, and adipose tissue are compared, when they are cultured with different collagen-based scaffolds or with fibrin glue. The results indicate that bone marrow cells are the best source of MSCs for osteogenic differentiation, and that an electrochemically aggregated collagen gives the highest cell viability and best osteogenic differentiation among the four kinds of scaffolds studied.

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