Macromol. Biosci. 10/2012

Authors

  • Shahed Al-Haque,

    1. Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College St, Rm. 407, M5S 3G9 Toronto, Ontario, Canada
    Search for more papers by this author
  • Jason W. Miklas,

    1. Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College St, Rm. 407, M5S 3G9 Toronto, Ontario, Canada
    Search for more papers by this author
  • Nicole Feric,

    1. Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College St, Rm. 407, M5S 3G9 Toronto, Ontario, Canada
    Search for more papers by this author
  • Loraine L. Y. Chiu,

    1. Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada
    Search for more papers by this author
  • Wen Li Kelly Chen,

    1. Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College St, Rm. 407, M5S 3G9 Toronto, Ontario, Canada
    Search for more papers by this author
  • Craig A. Simmons,

    1. Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College St, Rm. 407, M5S 3G9 Toronto, Ontario, Canada
    2. Department of Mechanical and Industrial Engineering, and Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    Search for more papers by this author
  • Milica Radisic

    Corresponding author
    1. Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College St, Rm. 407, M5S 3G9 Toronto, Ontario, Canada
    2. Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada
    • Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College St, Rm. 407, M5S 3G9 Toronto, Ontario, Canada.
    Search for more papers by this author

Abstract

original image

Cover: The ability of cardiac fibroblasts to sense the topography of their microenvironment varies with substrate stiffness. Stiffness and topography have an interactive effect on cell morphology and alignment. This paper demonstrates that 18 kPa topographically modified substrates optimally induce elongation and alignment of cardiac fibroblasts. Further details can be found in the article by S. Al-Haque, J. W. Miklas, N. Feric, L. L. Y. Chiu, W. L. K. Chen, C. A. Simmons, and M. Radisic* on page 1342.

Ancillary