In-situ Formation and Assembly of Gold Nanoparticles by Gum Arabic as Efficient Photothermal Agent for Killing Cancer Cells

Authors

  • Ching-Ping Liu,

    1. Center for Nanomedicine Research, Division of Medical Engineering Research, National Health Research Institutes, Zhunan, Taiwan
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  • Fong-Sian Lin,

    1. Center for Nanomedicine Research, Division of Medical Engineering Research, National Health Research Institutes, Zhunan, Taiwan
    2. Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan
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  • Chih-Te Chien,

    1. Center for Nanomedicine Research, Division of Medical Engineering Research, National Health Research Institutes, Zhunan, Taiwan
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  • Sheng-Yang Tseng,

    1. Department of Electrophysics, National Chiao Tung University, Hsinchu, Taiwan
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  • Chih-Wei Luo,

    1. Department of Electrophysics, National Chiao Tung University, Hsinchu, Taiwan
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  • Chien-Hung Chen,

    1. Center for Nanomedicine Research, Division of Medical Engineering Research, National Health Research Institutes, Zhunan, Taiwan
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  • Jen-Kun Chen,

    1. Center for Nanomedicine Research, Division of Medical Engineering Research, National Health Research Institutes, Zhunan, Taiwan
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  • Fan-Gang Tseng,

    1. Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan
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  • Yeukuang Hwu,

    1. Institute of Physics, Academia Sinica, Nankang, Taipei 115, Taiwan
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  • Leu-Wei Lo,

    1. Center for Nanomedicine Research, Division of Medical Engineering Research, National Health Research Institutes, Zhunan, Taiwan
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  • Chung-Shi Yang,

    1. Center for Nanomedicine Research, Division of Medical Engineering Research, National Health Research Institutes, Zhunan, Taiwan
    2. Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan
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  • Shu-Yi Lin

    Corresponding author
    1. Center for Nanomedicine Research, Division of Medical Engineering Research, National Health Research Institutes, Zhunan, Taiwan
    • Center for Nanomedicine Research, Division of Medical Engineering Research, National Health Research Institutes, 35 Keyan Road, Zhunan35053Taiwan

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  • Supporting Information is available from the Wiley Online Library or from the author.

Abstract

Gold nanoparticles (AuNPs) have been established to sufficiently eradicate tumors by means of heat production for photothermal therapy. However, the translation of the AuNPs from bench to the clinic still remains to be solved until realizing high bioclearance after treatment. Herein, we developed a simple strategy for simultaneous formation and assembly of small-size gold nanoparticles (Au-SNPs) to form a novel nanocomposite in the presence of gum arabic (GA) by synchrotron X-ray irradiation in an aqueous solution within 5 min. GA, a porous polysaccharide, can not only provide a confined space in which to produce uniform Au-SNPs (1.6 ± 0.7 nm in diameter), but can also facilitate the formation of Au-SNPs@GA (diameter ≈ 40 nm) after irradiating synchrotron X-rays. Specifically, the Au-SNPs@GA possesses high thermal stability and a strong photothermal effect for killing cancer cells. Importantly, a bioclearance study demonstrated that the Au-SNPs@GA can be gradually excreted by the renal and hepatobiliary system, which might be due to the breakdown and oxidation of GA under irradiating synchrotron X-rays. Thus, the novel gold nanocomposite can be promising photothermal agents for cancer treatment at the therapeutic level, minimizing toxicity concerns regarding long-term accumulation in vivo.mabi201300162-gra-0001

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