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Development of Multiple Stimuli Responsive Magnetic Polymer Nanocontainers as Efficient Drug Delivery Systems

Authors

  • Leto-Aikaterini Tziveleka,

    Corresponding author
    1. Institute for Advanced Materials, Physicochemical Processes, Nanotechnology & Microsystems, NCSR “Demokritos”, Athens GR-15310, Greece
    • Institute for Advanced Materials, Physicochemical Processes, Nanotechnology & Microsystems, NCSR “Demokritos”, Aghia Paraskevi Attikis, Athens GR-15310Greece

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  • Panayiotis Bilalis,

    1. Institute for Advanced Materials, Physicochemical Processes, Nanotechnology & Microsystems, NCSR “Demokritos”, Athens GR-15310, Greece
    Current affiliation:
    1. Industrial Chemistry Laboratory, Department of Chemistry, University of Athens, 15771 Athens, Greece
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  • Alexandros Chatzipavlidis,

    1. Institute for Advanced Materials, Physicochemical Processes, Nanotechnology & Microsystems, NCSR “Demokritos”, Athens GR-15310, Greece
    2. School of Chemical Engineering, National Technical University of Athens, Zografos, Athens, Greece
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  • Nikos Boukos,

    1. Institute for Advanced Materials, Physicochemical Processes, Nanotechnology & Microsystems, NCSR “Demokritos”, Athens GR-15310, Greece
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  • George Kordas

    Corresponding author
    1. Institute for Advanced Materials, Physicochemical Processes, Nanotechnology & Microsystems, NCSR “Demokritos”, Athens GR-15310, Greece
    • Institute for Advanced Materials, Physicochemical Processes, Nanotechnology & Microsystems, NCSR “Demokritos”, Aghia Paraskevi Attikis, Athens GR-15310Greece

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  • Supporting Information is available from the Wiley Online Library or from the author.

Abstract

Magnetic nanodevices based on poly[(methacrylic acid)-co-(N-isopropylacrylamide)] [P(MAA-co-NIPAAm)] are prepared and used as drug delivery systems employing daunorubicin (DNR) as a model drug. The magnetic nanocontainers exploit the pH, temperature, and magnetic response of the polymeric shell constituents and magnetic nanoparticles, respectively, for controlled pH, temperature and alternating magnetic field triggered drug release. The in vitro cytotoxicity of both DNR-loaded and empty nanocontainers is examined on MCF-7 breast cancer cells along with the intracellular distribution of DNR. The results show that the DNR-loaded nanocontainers have an anti-tumor effect comparable to the free drug. The current observations provide important information for potent drug delivery and release systems.mabi201300212-gra-0001

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