Bioreducible Polycations in Nucleic Acid Delivery: Past, Present, and Future Trends

Authors

  • David Oupický,

    Corresponding author
    1. Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Durham Research Center, Omaha, NE 68198-5830, USA
    Search for more papers by this author
  • Jing Li

    1. Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Durham Research Center, Omaha, NE 68198-5830, USA
    Search for more papers by this author

Abstract

Polycations that are degradable by reduction of disulfide bonds are developed for applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of bioreducible polycations and discusses current understanding of the mechanism of action of bioreducible polyplexes. Emphasis is placed on the relationship between the biological redox environment and toxicity, trafficking, transfection activity, and in vivo behavior of bioreducible polycations and polyplexes.mabi201400061-gra-0001

Ancillary