Macromolecular Bioscience

Cover image for Vol. 11 Issue 7

July 7, 2011

Volume 11, Issue 7

Pages 859–998

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Contents
    5. Feature Article
    6. Communication
    7. Full Papers
    1. Macromol. Biosci. 7/2011

      Parul Rungta, Yuriy P. Bandera, Ryan D. Roeder, Yangchun Li, William S. Baldwin, Deepti Sharma, Michael G. Sehorn, Igor Luzinov and Stephen H. Foulger

      Version of Record online: 29 JUN 2011 | DOI: 10.1002/mabi.201190018

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      Front Cover: The cover depicts the surface of a poly-(propargyl acrylate) particle, which has been surface-modified with indocyanine green, a near-infrared fluorophore, which exhibited no emission until they were “activated” by bovine serum albumin. These particles were employed as cytotoxic oxygen-generating nanoparticles in photodynamic therapy. Further details can be found in the article by P. Rungta, Y. P. Bandera, R. D. Roeder, Y. Li, W. S. Baldwin, D. Sharma, M. G. Sehorn, I. Luzinov, and S. H. Foulger* on page 927.

  2. Back Cover

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Contents
    5. Feature Article
    6. Communication
    7. Full Papers
    1. Macromol. Biosci. 7/2011

      Chang Ho Seo, Katsuko Furukawa, Yuji Suzuki, Nobuhide Kasagi, Takanori Ichiki and Takashi Ushida

      Version of Record online: 29 JUN 2011 | DOI: 10.1002/mabi.201190019

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      Back Cover: For a quantitative analysis of the relationship between topographical variation and the differentiation of stem cells, we designed well-ordered lattice micropatterns ranging from flat to 8µm and systematically examined the effectiveness of topography variation on osteogenic differentiation. Further details can be found in the article by C. H. Seo, K. Furukawa, Y. Suzuki, N. Kasagi, T. Ichiki, and T. Ushida* on page 938.

  3. Contents

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Contents
    5. Feature Article
    6. Communication
    7. Full Papers
    1. Macromol. Biosci. 7/2011 (pages 859–863)

      Version of Record online: 29 JUN 2011 | DOI: 10.1002/mabi.201190017

  4. Feature Article

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Contents
    5. Feature Article
    6. Communication
    7. Full Papers
    1. Polymer/Hemoglobin Assemblies: Biodegradable Oxygen Carriers for Artificial Red Blood Cells (pages 865–875)

      Taihang Li, Xiabin Jing and Yubin Huang

      Version of Record online: 10 FEB 2011 | DOI: 10.1002/mabi.201000469

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      New types of artificial oxygen carriers with a cellular structure utilizing biodegradable amphiphilic copolymers and hemoglobin as matrix materials to stabilize hemoglobin molecules through various approaches, especially the nano-scale self-assembly technique, are discussed. These types of artificial red blood cell systems, which possess safety, long term blood circulation ability and efficient oxygen transportation capacity, show great advantages for potential clinical application.

  5. Communication

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Contents
    5. Feature Article
    6. Communication
    7. Full Papers
    1. Lysozyme Coated DNA and DNA/SWNT Fibers by Solution Spinning (pages 875–881)

      Dhriti Nepal, Marilyn L. Minus and Satish Kumar

      Version of Record online: 5 APR 2011 | DOI: 10.1002/mabi.201000490

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      The image shows DNA/SWNT and LSZ aqueous solutions (left) which when mixed at specific ratios result in the formation of gel fibers (wet—middle and dry—right). LSZ protein is used to condense the DNA into fibrillar gel structures. For the fibers, DNA exhibits better chain packing compared to as-received DNA. Both DNA/LSZ and DNA/LSZ/SWNT fibers are fabricated using this process. Due to the inherit activity of the LSZ, the fibers also exhibit anti-microbial properties. This work illustrates a novel method for the formation of DNA and DNA/SWNT based functional composite materials.

  6. Full Papers

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Contents
    5. Feature Article
    6. Communication
    7. Full Papers
    1. Cell Specific Peptide-Conjugated Polysaccharide Nanogels for Protein Delivery (pages 882–888)

      Asako Shimoda, Shin-ichi Sawada and Kazunari Akiyoshi

      Version of Record online: 13 APR 2011 | DOI: 10.1002/mabi.201000491

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      RGD (Arg-Gly-Asp) peptide-modified polysaccharide nanogel for targeted delivery is prepared. This nanogel traps proteins and internalizes into the cells through integrin receptor-mediated endocytosis with no toxicity. Because of the multiple cellular uptake pathways, RGD-modified nanogels escape from endosomes. Collectively, this carrier is useful for protein delivery.

    2. Microgels for the Encapsulation and Stimulus-Responsive Release of Molecules with Distinct Polarities (pages 889–896)

      Dinesh Jagadeesan, Irina Nasimova, Ilya Gourevich, Sergey Starodubtsev and Eugenia Kumacheva

      Version of Record online: 19 APR 2011 | DOI: 10.1002/mabi.201100045

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      Poly( N -isopropylacrylamide) microgel particles encapsulated with oil droplets are synthesized using microfluidics. The particles are loaded with molecules of different polarities. A temperature-induced release of the cargo is observed. This has potential for multiple drug delivery systems.

    3. Biodegradable Poly(ethylene carbonate) Nanoparticles as a Promising Drug Delivery System with “Stealth” Potential (pages 897–904)

      Nadja Bege, Thomas Renette, Mirko Jansch, Regina Reul, Olivia Merkel, Holger Petersen, Catherine Curdy, Rainer H. Müller and Thomas Kissel

      Version of Record online: 5 APR 2011 | DOI: 10.1002/mabi.201000496

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      Creating stealthy drug delivery systems, avoiding opsonization, and phagocytosis is still a great challenge. Here biocompatible poly(ethylene carbonate) is used for nanosphere preparation gaining well defined particles with a narrow size distribution. 2D-PAGE studies reveal a low amount of adsorbed human proteins compared to polystyrene. In uptake experiments with murine macrophages the nanoparticles are not recognized confirming stealth potential in vitro.

    4. Hybrid Nanoparticle Design Based on Cationized Gelatin and the Polyanions Dextran Sulfate and Chondroitin Sulfate for Ocular Gene Therapy (pages 905–913)

      Giovanni Konat Zorzi, Jenny Evelin Párraga, Begoña Seijo and Alejandro Sánchez

      Version of Record online: 8 APR 2011 | DOI: 10.1002/mabi.201100005

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      New hybrid nanoparticles composed of cationized gelatin and natural polyanions are developed and characterized. The incorporation of chondroitin sulfate or dextran sulfate in cationized gelatin nanoparticles decreases their toxicity while preserving their transfection efficiency in human corneal cells. These nanoparticles are potential candidates for the development of safer and more effective nanomedicines for ocular therapy.

    5. Biodegradable Glutaraldehyde-crosslinked Casein Conduit Promotes Regeneration after Peripheral Nerve Injury in Adult Rats (pages 914–926)

      Walter Wang, Jia-Horng Lin, Chin-Chuan Tsai, Hao-Che Chuang, Chien-Yi Ho, Chun-Hsu Yao and Yueh-Sheng Chen

      Version of Record online: 15 APR 2011 | DOI: 10.1002/mabi.201000498

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      A novel glutaraldehyde-cross-linked casein protein (GCC) conduit is developed. NF- κ B-dependent bioluminescence in living mice is used to monitor the immune response caused by the implanted GCC conduit. Subsequently, this new protein-based biodegradable conduit is submitted to mechanical, cytotoxic, morphological, and biological tests. Results show that the conduit has properties of great interest towards the repair of regenerating nerve tissues.

    6. Selective Imaging and Killing of Cancer Cells with Protein-Activated Near-Infrared Fluorescing Nanoparticles (pages 927–937)

      Parul Rungta, Yuriy P. Bandera, Ryan D. Roeder, Yangchun Li, William S. Baldwin, Deepti Sharma, Michael G. Sehorn, Igor Luzinov and Stephen H. Foulger

      Version of Record online: 8 APR 2011 | DOI: 10.1002/mabi.201100043

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      Poly(propargyl acrylate) (PA) particles surface modified with an azide-terminated indocyanine green (azICG), a near-infrared emitter, and poly(ethylene glycol) (azPEG) chains of various molecular weights, were employed as protein-activated cytotoxic oxygen generating nanoparticles in photodynamic therapy (PDT) studies with HepG2 cancer cells.

    7. A Topographically Optimized Substrate with Well-Ordered Lattice Micropatterns for Enhancing the Osteogenic Differentiation of Murine Mesenchymal Stem Cells (pages 938–945)

      Chang Ho Seo, Katsuko Furukawa, Yuji Suzuki, Nobuhide Kasagi, Takanori Ichiki and Takashi Ushida

      Version of Record online: 25 FEB 2011 | DOI: 10.1002/mabi.201000477

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      A topographically optimized substrate promotes osteogenic differentiation of murine mesenchymal stem cells. Through quantitative analysis between topographical variation and the differentiation of stem cells, the effectiveness of topography variation on osteogenic differentiation is analyzed. The effectiveness of the osteogenic differentiation has a peak around 3µm micropatterns.

    8. Evaluation of pH-Sensitive Poly(β-amino ester)-graft-poly(ethylene glycol) and its Usefulness as a pH-Sensor and Protein Carrier (pages 946–951)

      Min Sang Kim, Guang Hui Gao, Seong Woo Kang and Doo Sung Lee

      Version of Record online: 15 APR 2011 | DOI: 10.1002/mabi.201100020

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      Poly( β -amino ester)- graft -poly(ethylene glycol) exhibiting pH-sensitive properties can be used as a pH-sensor detecting environmental pH and a protein carrier delivering into acidic area. Herein, the possibility for its use as a pH-sensor and protein carrier is evaluated from excimer formation of pyrene labeled copolymer and fluorescence resonance energy transfer phenomena of rhodamine B isothiocyanate labeled copolymer.

    9. Crosslinking of Trimethylene Carbonate and D, L-Lactide (Co-) Polymers by Gamma Irradiation in the Presence of Pentaerythritol Triacrylate (pages 952–961)

      Erhan Bat, Theo G. van Kooten, Jan Feijen and Dirk W. Grijpma

      Version of Record online: 8 APR 2011 | DOI: 10.1002/mabi.201100031

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      A practical method of enhancing network formation during sterilization by gamma irradiation of D,L-lactide and trimethylene carbonate-based (co)polymers is presented. The thermal- and mechanical properties of the networks can readily be tuned by adjusting the copolymer composition. In vitro assays show that the (co)polymer networks and their degradation products are biocompatible.

    10. Disulfide Core Cross-Linked PEGylated Polypeptide Nanogel Prepared by a One-Step Ring Opening Copolymerization of N-Carboxyanhydrides for Drug Delivery (pages 962–969)

      Tao Xing, Bin Lai, Xiaodong Ye and Lifeng Yan

      Version of Record online: 5 APR 2011 | DOI: 10.1002/mabi.201000510

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      A novel disulfide core cross-linked PEGylated polypeptide nanogel has been synthesized. The synthesis includes a one-step ring opening copolymerization of γ-benzyl L-glutamate N-carboxyanhydride and L-cystine N-carboxyanhydride using an amino group-terminated poly(ethylene glycol) methyl ether as initiator. The nanogel is biocompatibile and displayed a high drug loading and controlled release of indomethacin.

    11. A Poly(acrylic acid)-block-Poly(L-glutamic acid) Diblock Copolymer with Improved Cell Adhesion for Surface Modification (pages 970–977)

      Bin Cao, Shifeng Yan, Kunxi Zhang, Zhijiang Song, Tian Cao, Xuesi Chen, Lei Cui and Jingbo Yin

      Version of Record online: 26 APR 2011 | DOI: 10.1002/mabi.201100010

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      A novel PAA-b-PLGA copolymer is synthesized and characterized. Bioactive multilayer films composed of PAA-b-PLGA and chitosan are obtained on the surface of poly(L-lactic acid). The multilayer film provides a new option for improving the cell attachment in surface modification for tissue engineering.

    12. The Influence of Patterned Nanofiber Meshes on Human Mesenchymal Stem Cell Osteogenesis (pages 978–987)

      Albino Martins, Marta L. Alves da Silva, Susana Faria, Alexandra P. Marques, Rui L. Reis and Nuno M. Neves

      Version of Record online: 11 APR 2011 | DOI: 10.1002/mabi.201100012

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      Special collectors allow the production of electrospun patterned nanofiber meshes. The influence of mesh topography on the osteogenic differentiation of human bone marrow mesenchymal stem cells is investigated. Phenotypic and genotypic characterization of differentiated MSCs demonstrates the suitability of ordered microstructures and patterns for a bone tissue engineering strategy.

    13. Generic, Anthracene-Based Hydrogel Crosslinkers for Photo-controllable Drug Delivery (pages 988–998)

      Laura A. Wells, Michael A. Brook and Heather Sheardown

      Version of Record online: 20 MAY 2011 | DOI: 10.1002/mabi.201100001

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      Photoreversible, dimerizable polyethylene glycol–anthracene (PEG–anthracene) macromolecules were designed and synthesized as generic, graftable photocrosslinkers that may be bound to different polymers. When bound to alginate and hyaluronan, PEG–anthracene introduces photoinduced crosslinking via dimerization. Preliminary tests demonstrate cytocompatibility and light-controlled drug delivery.

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