Dendrimer-Based Macromolecular Conjugate for the Kidney-Directed Delivery of a Multitargeted Sunitinib Analogue (pages 93–103)
M. E. (Emmy) M. Dolman, Kim M. A. van Dorenmalen, Ebel H. E. Pieters, Rolf W. Sparidans, Marie Lacombe, Bálint Szokol, László Őrfi, György Kéri, Niels Bovenschen, Gert Storm, Wim E. Hennink and Robbert J. Kok
Article first published online: 13 OCT 2011 | DOI: 10.1002/mabi.201100277
Coupling of a novel multitargeted sunitinib analogue to NH2-PAMAM-G3 dendrimers via the platinum (II)-based ULS yields a conjugate with retained pharmacological activity. It accumulates rapidly in the kidneys and provides high intrarenal drug levels that last for several days, making such conjugates promising for the development of novel therapeutics for the treatment of renal diseases.