Macromolecular Bioscience

Cover image for Vol. 12 Issue 1

January 2012

Volume 12, Issue 1

Pages 3–131

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Editorial
    6. Frontispiece
    7. Special Article Series - Full Papers
    8. Feature Articles
    9. Communications
    10. Full Papers
    1. Macromol. Biosci. 1/2012

      Sung Ho Yang, Taemin Lee, Eunyong Seo, Eun Hyea Ko, Insung S. Choi and Byeong-Su Kim

      Article first published online: 5 JAN 2012 | DOI: 10.1002/mabi.201290002

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      Cover: The cover features the first demonstration of interfacing the living yeast cells with graphene nanosheath. The versatile layer-by-layer assembly will allow the potential of integrating new physical and chemical functions for living cells while preserving their viability. Further details can be found in the article by S. H. Yang, T. Lee, E. Seo, E. H. Ko, I. S. Choi,* and B.-S. Kim* on page 61.

  2. Masthead

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Editorial
    6. Frontispiece
    7. Special Article Series - Full Papers
    8. Feature Articles
    9. Communications
    10. Full Papers
    1. Macromol. Biosci. 1/2012

      Article first published online: 5 JAN 2012 | DOI: 10.1002/mabi.201290003

  3. Contents

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Editorial
    6. Frontispiece
    7. Special Article Series - Full Papers
    8. Feature Articles
    9. Communications
    10. Full Papers
    1. Macromol. Biosci. 1/2012 (pages 3–7)

      Article first published online: 5 JAN 2012 | DOI: 10.1002/mabi.201290001

  4. Editorial

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Editorial
    6. Frontispiece
    7. Special Article Series - Full Papers
    8. Feature Articles
    9. Communications
    10. Full Papers
    1. You have free access to this content
  5. Frontispiece

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Editorial
    6. Frontispiece
    7. Special Article Series - Full Papers
    8. Feature Articles
    9. Communications
    10. Full Papers
    1. Macromol. Biosci. 1/2012

      Article first published online: 5 JAN 2012 | DOI: 10.1002/mabi.201290000

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      This issue of Macromolecular Bioscience contains articles of the Special Series “Advanced Polymers in Stem Cell Biology & Medicine”.

  6. Special Article Series - Full Papers

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Editorial
    6. Frontispiece
    7. Special Article Series - Full Papers
    8. Feature Articles
    9. Communications
    10. Full Papers
    1. Fabrication of Substrates with Defined Mechanical Properties and Topographical Features for the Study of Cell Migration (pages 12–20)

      Jonathan M. Charest, Joseph P. Califano, Shawn P. Carey and Cynthia A. Reinhart-King

      Article first published online: 21 OCT 2011 | DOI: 10.1002/mabi.201100264

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      Cellular substrates containing well-defined mechanical properties, topographical features and micro-contacted printed adhesive regions are described and evaluated for pattern fidelity as a function of polymer formulation. The effect of substrate mechanical properties on contact guidance is explored.

    2. Development of a Biodegradable, Temperature-sensitive Dextran-based Polymer as a Cell-detaching Substrate (pages 21–28)

      Guoming Sun, Sravanti Kusuma and Sharon Gerecht

      Article first published online: 15 NOV 2011 | DOI: 10.1002/mabi.201100258

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      TSDAIE is a dextran-based, biodegradable, temperature-sensitive polymer developed as a substrate for cell detachment to improve current stem cell culture techniques. At temperatures higher than its lower critical solution temperature (LCST), TSDAIE is hydrophobic and facilitates cell attachment. When TSDAIE is cooled to temperatures below its LCST, TSDAIE is hydrophilic and promotes cell detachment.

  7. Feature Articles

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Editorial
    6. Frontispiece
    7. Special Article Series - Full Papers
    8. Feature Articles
    9. Communications
    10. Full Papers
    1. DNA-Inspired Hierarchical Polymer Design: Electrostatics and Hydrogen Bonding in Concert (pages 29–39)

      Sean T. Hemp and Timothy E. Long

      Article first published online: 15 DEC 2011 | DOI: 10.1002/mabi.201100355

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      DNA and proteins use a variety of noncovalent interactions (e.g., electrostatics, π-π stacking, hydrogen bonding, hydrophobic interactions) to assemble into quaternary structures. Today, researchers not only incorporate DNA nucleobases into monomers/polymers, but utilize electrostatics and hydrogen bonding to orthogonally functionalize a polymer backbone.

    2. Hybrid Polymeric Nanomaterials for siRNA Delivery and Imaging (pages 40–48)

      Hyejung Mok and Tae Gwan Park

      Article first published online: 16 AUG 2011 | DOI: 10.1002/mabi.201100169

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      Recent studies on the design and preparation of polymeric hybrid nanomaterials as attractive siRNA carrier systems are described, highlighting diverse conjugation and formulation strategies for the incorporation of siRNA and imaging agents. The optimal modification sites of the siRNA, the types of crosslinker, and several kinds of inorganic materials are evaluated for the preparation of proper nanomaterials.

  8. Communications

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Editorial
    6. Frontispiece
    7. Special Article Series - Full Papers
    8. Feature Articles
    9. Communications
    10. Full Papers
    1. Combination Self-Assembly of β-Sheet Peptides and Carbon Nanotubes: Functionalizing Carbon Nanotubes with Bioactive β-Sheet Block Copolypeptides (pages 49–54)

      Woo-jin Jeong and Yong-beom Lim

      Article first published online: 20 SEP 2011 | DOI: 10.1002/mabi.201100284

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      With combination self-assembly between β-sheet block copolypeptides and CNTs, peptide-decorated bioactive carbon nanotubes or simple bioactive β-sheet peptide nanoribbons can be constructed, depending on the force balance processes between two classes of competing forces during self-assembly. This can be important in the fabrication of bioactive peptide/CNT hybrids and in the control of protein-misfolding diseases.

    2. Synthesis and in vitro Characterization of Semitelechelic Poly[N-(2-hydroxypropyl)methacrylamide]–Trastuzumab Conjugates Targeted to Breast Cancer (pages 55–60)

      Jun H. Lee, Gauri Sabnis and Anjan Nan

      Article first published online: 25 AUG 2011 | DOI: 10.1002/mabi.201100152

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      Semitelechelic (ST) poly[N-(2-hydroxypropyl)methacrylamide]–trastuzumab conjugates are synthesized and evaluated in vitro. When conjugated, the ST backbone shows favorable characteristics of a potential novel drug delivery system that actively targets human epidermal growth factor receptor type 2 overexpressing tumors. The conjugate exhibits prolonged anticancer activity compared to free TRZ.

  9. Full Papers

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Editorial
    6. Frontispiece
    7. Special Article Series - Full Papers
    8. Feature Articles
    9. Communications
    10. Full Papers
    1. You have free access to this content
      Interfacing Living Yeast Cells with Graphene Oxide Nanosheaths (pages 61–66)

      Sung Ho Yang, Taemin Lee, Eunyong Seo, Eun Hyea Ko, Insung S. Choi and Byeong-Su Kim

      Article first published online: 25 OCT 2011 | DOI: 10.1002/mabi.201100268

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      Interfacing living yeast cells with graphene nanosheaths is achieved via versatile LbL assembly. Oppositely charged GO nanosheets are coated alternatingly onto the individual yeast cells, preserving the viability of the yeast cells and affording a means of interfacing graphene with living yeast cells. The method allows to provide new physical and chemical functions for living cells.

    2. Biocompatibility and Structural Stability of a Laminin Biopolymer (pages 67–74)

      Elisabete Freire, Madalena Martins Sant'Ana Barroso, Richard Norman Klier and Tatiana Coelho-Sampaio

      Article first published online: 12 OCT 2011 | DOI: 10.1002/mabi.201100125

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      Polylaminin is a biomimetic polymer of the protein laminin that is shown to be temperature-resistant and stable in a cellular environment. When neuronal cells isolated from embryonic brain cortex are platted on polyLM they extend very long neurites (red), which grow interwoven with the mesh formed by the polymer (green).

    3. Silk-Based Nanocomplexes with Tumor-Homing Peptides for Tumor-Specific Gene Delivery (pages 75–82)

      Keiji Numata, Aneta J. Mieszawska-Czajkowska, Laura A. Kvenvold and David L. Kaplan

      Article first published online: 3 NOV 2011 | DOI: 10.1002/mabi.201100274

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      Complexes of recombinant silk molecules with tumor-homing peptides and plasmid DNA are designed for use as non-cytotoxic and target-specific gene carriers. It is shown that these bioengineered silk systems can serve as versatile and useful new platforms for non-viral gene delivery or drug delivery.

    4. Fluorescent Micelles Based on Star Amphiphilic Copolymer with a Porphyrin Core for Bioimaging and Drug Delivery (pages 83–92)

      Luzhong Zhang, Ying Lin, Yajun Zhang, Rui Chen, Zhenshu Zhu, Wei Wu and Xiqun Jiang

      Article first published online: 25 AUG 2011 | DOI: 10.1002/mabi.201100197

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      Star-shaped poly(ε-caprolactone)-b-poly(ethylene oxide) (TAPP-PCL-mPEO) amphiphilic copolymer with a tetrakis-(4-aminophenyl)-terminated porphyrin core are synthesized and could self-assemble into micelles. The in vivo real-time fluorescent imaging revealed that the micelles could accumulate at tumor site via the blood circulation in tumor-bearing mice. In vivo antitumor efficacy examinations indicated that the PTX-loaded micelles had significantly superior efficacy than Taxol.

    5. Dendrimer-Based Macromolecular Conjugate for the Kidney-Directed Delivery of a Multitargeted Sunitinib Analogue (pages 93–103)

      M. E. (Emmy) M. Dolman, Kim M. A. van Dorenmalen, Ebel H. E. Pieters, Rolf W. Sparidans, Marie Lacombe, Bálint Szokol, László Őrfi, György Kéri, Niels Bovenschen, Gert Storm, Wim E. Hennink and Robbert J. Kok

      Article first published online: 13 OCT 2011 | DOI: 10.1002/mabi.201100277

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      Coupling of a novel multitargeted sunitinib analogue to NH2-PAMAM-G3 dendrimers via the platinum (II)-based ULS yields a conjugate with retained pharmacological activity. It accumulates rapidly in the kidneys and provides high intrarenal drug levels that last for several days, making such conjugates promising for the development of novel therapeutics for the treatment of renal diseases.

    6. Non-Woven Fibrous Materials with Antibacterial Properties Prepared by Tailored Attachment of Quaternized Chitosan to Electrospun Mats from Maleic Anhydride Copolymer (pages 104–115)

      Milena Ignatova, Zhanina Petkova, Nevena Manolova, Nadya Markova and Iliya Rashkov

      Article first published online: 16 AUG 2011 | DOI: 10.1002/mabi.201100178

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      Microfibrous materials that decrease the adhesion of pathogenic bacteria and exhibit good antibacterial activity are obtained by attachment of quaternized chitosan derivatives with alkyl substituents of different chain lengths to electrospun mats from maleic anhydride copolymers. These new materials are promising for applications such as wound dressings and antimicrobial filters.

    7. Heparin-Like Macromolecules for the Modification of Anticoagulant Biomaterials (pages 116–125)

      Fen Ran, Shengqiang Nie, Jie Li, Baihai Su, Shudong Sun and Changsheng Zhao

      Article first published online: 4 OCT 2011 | DOI: 10.1002/mabi.201100249

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      Heparin-like structured macromolecules are synthesized and directly blended with poly(ethersulfone) to prepare flat-sheet membranes through liquid/liquid phase separation. The synthesized polymeric material retards blood clotting and the modified membrane exhibits good anticoagulant ability and blood compatibility due to the existence of the important functional groups SO3H, COOH and OH.

    8. Protein-Resistant and Fibrinolytic Polyurethane Surfaces (pages 126–131)

      Zhaoqiang Wu, Hong Chen, Xiaoli Liu and John L. Brash

      Article first published online: 13 OCT 2011 | DOI: 10.1002/mabi.201100211

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      A new method to prepare PU surfaces with resistance to non-specific protein adsorption and a high capacity to bind plasminogen from plasma is reported. A poly(OEGMA-co-HEMA) random copolymer is grafted to the PU by surface-initiated radical polymerization. The OEGMA provides effective protein resistance and the HEMA provides a high density of OH groups for attachment of lysine.

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