Macromolecular Bioscience

Cover image for Vol. 12 Issue 9

September 2012

Volume 12, Issue 9

Pages 1151–1289

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Review
    7. Full Papers
    1. Macromol. Biosci. 9/2012

      Adrian Sulistio, Anton Blencowe, Jiapei Wang, Gary Bryant, Xiaoqing Zhang and Greg G. Qiao

      Article first published online: 4 SEP 2012 | DOI: 10.1002/mabi.201290032

      Thumbnail image of graphical abstract

      Front Cover: Reversible self-assembly of Poly(L-glutamic acid)-b-poly(L-lysine-r-dihydroxyphenyl alanine) at acidic and basic pHs forms an ellipsoidal morphology and vesicles, respectively. Subsequent O2-mediated oxidation of the phenolic groups of the DOPA at pH 12 lead to intermolecular dimerization to stabilize the vesicles via in situ cross-linking. Further details can be found in the article by A. Sulistio, A. Blencowe, J. Wang, G. Bryant, X. Zhang, G. G. Qiao* on page 1220.

  2. Back Cover

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Review
    7. Full Papers
    1. Macromol. Biosci. 9/2012

      Krzysztof Babiuch, David Pretzel, Tatiana Tolstik, Antje Vollrath, Sarmiza Stanca, Franziska Foertsch, C. Remzi Becer, Michael Gottschaldt, Christoph Biskup and Ulrich S. Schubert

      Article first published online: 4 SEP 2012 | DOI: 10.1002/mabi.201290033

      Thumbnail image of graphical abstract

      Back Cover: HepG2 hepatocarcinoma cells take up water soluble homo-glycopolymers as well as nanoparticles of polystyrene block copolymers in a sugar-type dependent manner. Preferential internalization of green-fluorescent, galactosylated homopolymers and nanoparticles (20 nm in diameter) could be observed by confocal laser scanning microscopy. Further details can be found in the article by K. Babiuch, D. Pretzel, T. Tolstik, A. Vollrath, S. Stanca, F. Foertsch, C. R. Becer, M. Gottschaldt, C. Biskup, U. S. Schubert* on page 1190.

  3. Masthead

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Review
    7. Full Papers
    1. Macromol. Biosci. 9/2012

      Article first published online: 4 SEP 2012 | DOI: 10.1002/mabi.201290034

  4. Contents

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Review
    7. Full Papers
    1. Macromol. Biosci. 9/2012 (pages 1151–1155)

      Article first published online: 4 SEP 2012 | DOI: 10.1002/mabi.201290031

  5. Review

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Review
    7. Full Papers
    1. Recent Insights Into the Biomedical Applications of Shape-memory Polymers (pages 1156–1171)

      Maria C. Serrano and Guillermo A. Ameer

      Article first published online: 6 AUG 2012 | DOI: 10.1002/mabi.201200097

      Thumbnail image of graphical abstract

      Shape-memory polymers are a new generation of polymeric materials with advanced properties such as shape change in response to specific stimuli. As shown in the figure, intravascular stents may benefit from advances in this field.

  6. Full Papers

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Review
    7. Full Papers
    1. Unraveling the Uptake Mechanisms of Mannan Nanogel in Bone-Marrow-Derived Macrophages (pages 1172–1180)

      Sílvia A. Ferreira, Alexandra Correia, Pedro Madureira, Manuel Vilanova and Francisco M. Gama

      Article first published online: 16 JUL 2012 | DOI: 10.1002/mabi.201200075

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      Confocal and flow cytometric analysis allied to inhibition studies provide quantitative information on the level of internalization and intracellular fate of nanomaterials designed for biomedical applications. The mechanisms used by macrophages in the uptake and intracellular trafficking of mannan nanogel are portrayed.

    2. Membrane Affinity and Antibacterial Properties of Cationic Polyelectrolytes With Different Hydrophobicity (pages 1181–1189)

      Éva Kiss, Elisabeth T. Heine, Katalin Hill, Ying Chun He, Nina Keusgen, Csanád B. Pénzes, Donát Schnöller, Gergő Gyulai, Aleksandra Mendrek, Helmut Keul and Martin Moeller

      Article first published online: 25 JUL 2012 | DOI: 10.1002/mabi.201200078

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      The antibacterial behavior of cationic polyelectrolytes is studied. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers. The polymers are found to be effective in inhibiting proliferation of E. coli, B. subtilis and S. aureus. An optimum structure is identified on the basis of antibacterial and hemolytic tests.

    3. Uptake of Well-Defined, Highly Glycosylated, Pentafluorostyrene-Based Polymers and Nanoparticles by Human Hepatocellular Carcinoma Cells (pages 1190–1199)

      Krzysztof Babiuch, David Pretzel, Tatiana Tolstik, Antje Vollrath, Sarmiza Stanca, Franziska Foertsch, C. Remzi Becer, Michael Gottschaldt, Christoph Biskup and Ulrich S. Schubert

      Article first published online: 25 JUN 2012 | DOI: 10.1002/mabi.201200024

      Thumbnail image of graphical abstract

      Preferential uptake of 1-thio-β-D-galactose substituted to poly(pentafluorostyrene) via thiol/para-fluorine “click” reaction by a HepG2 hepatocarcinoma cell line is observed. Cells internalize water-soluble glycopolymers as well as nanoparticles of polystyrene block copolymers in a sugar-type and concentration-dependent manner, as confirmed by fluorescence microscopy and flow cytometry.

    4. Novel Biopolymer Matrices for Microencapsulation of Phages: Enhanced Protection Against Acidity and Protease Activity (pages 1200–1208)

      Cecilia Dini, Germán A. Islan, Patricio J. de Urraza and Guillermo R. Castro

      Article first published online: 30 JUL 2012 | DOI: 10.1002/mabi.201200109

      Thumbnail image of graphical abstract

      The development of food-grade matrices with a high encapsulation efficiency of biological entities such as phages encourages their in vivo application. A matrix is described increases phage resistance to simulated gastric conditions significantly and offers a low cost of raw materials and its simple synthesis make it a promising new technology in phage therapy.

    5. Fluorescence-Labeled Immunomicelles: Preparation, in vivo Biodistribution, and Ability to Cross the Blood–Brain Barrier (pages 1209–1219)

      Jun Yue, Shi Liu, Rui Wang, Xiuli Hu, Zhigang Xie, Yubin Huang and Xiabin Jing

      Article first published online: 13 JUL 2012 | DOI: 10.1002/mabi.201200037

      Thumbnail image of graphical abstract

      In vitro cell uptake and in vivo biodistribution of OX26-conjugated, florescent molecule RhB-labeled immunomicelles are investigated. The results indicate that OX26-conjugation can increase the uptake efficiency of micelles by target cells and the brain uptake of immunomicelles is much more than that of the OX26-free micelles.

    6. Stabilization of Peptide-Based Vesicles via in situ Oxygen-Mediated Cross-Linking (pages 1220–1231)

      Adrian Sulistio, Anton Blencowe, Jiapei Wang, Gary Bryant, Xiaoqing Zhang and Greg G. Qiao

      Article first published online: 13 JUL 2012 | DOI: 10.1002/mabi.201200048

      Thumbnail image of graphical abstract

      Stabilization of peptide-based reversible vesicles from block copolypeptide is performed by in situ cross-linking of the inner layer of the vesicle shell via oxygen-mediated phenolic oxidation at basic pH. The cross-linked vesicles are able to maintain their shape when the pH of the environment is reduced to acidic pH, which is not observed for the non-cross-linked vesicles.

    7. “Click & Seed” Approach to the Biomimetic Modification of Material Surfaces (pages 1232–1242)

      Vladimír Proks, Josef Jaroš, Ognen Pop-Georgievski, Jan Kučka, Štěpán Popelka, Petr Dvořák, Aleš Hampl and František Rypáček

      Article first published online: 26 JUL 2012 | DOI: 10.1002/mabi.201200095

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      A simple, versatile, protein-repulsive, substrate-independent biomimetic surface modification is presented that is based on the creation of a PEO brush on a polydopamine anchoring layer and its capacity for selective follow-up modifications with various ligands using a copper-catalyzed alkyne-azide cycloaddition reaction. The modified surface allows direct cell seeding and controlled cultivation.

    8. Plasmid DNA Microgels for a Therapeutical Strategy Combining the Delivery of Genes and Anticancer Drugs (pages 1243–1252)

      Diana Costa, Artur J. M. Valente, M. Graça Miguel and João Queiroz

      Article first published online: 26 JUL 2012 | DOI: 10.1002/mabi.201200096

      Thumbnail image of graphical abstract

      A new perspective in cancer treatment is offered that includes a combination of chemotherapy and gene delivery. Biocompatible and photodegradable pDNA microgels appear as good candidates for the co-delivery of p53-encoding pDNA and doxorubicin. In vitro transfection leads to the expression of p53 protein in cancer cells, leading to normal cell function re-establishment.

    9. Mechanical and Biological Performances of New Scaffolds Made of Collagen Hydrogels and Fibroin Microfibers for Vascular Tissue Engineering (pages 1253–1264)

      Mariana Agostini de Moraes, Estelle Paternotte, Diego Mantovani and Marisa Masumi Beppu

      Article first published online: 30 JUL 2012 | DOI: 10.1002/mabi.201200060

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      A 3D scaffold made of collagen hydrogel and fibroin microfibers is presented. A uniform dispersion of microfibers and optimized mechanical properties are achieved. Porcine smooth muscle cells proliferate and spread better in the collagen/fibroin hydrogel than in the pure collagen hydrogel. The composite hydrogel represents a promising scaffold in the field of vascular tissue engineering.

    10. Halloysite Clay Nanotubes for Resveratrol Delivery to Cancer Cells (pages 1265–1271)

      Viviana Vergaro, Yuri M. Lvov and Stefano Leporatti

      Article first published online: 8 AUG 2012 | DOI: 10.1002/mabi.201200121

      Thumbnail image of graphical abstract

      Resveratrol-loaded HNTs show high cytotoxicity and a sustained release drug behaviour caused by polyelelectrolyte multilayer coating: cells are killed by resveratrol in a concentration-time fashion.

    11. Thermoresponsive Aggregation Behavior of Triterpene–Poly(ethylene oxide) Conjugates in Water (pages 1272–1278)

      Junpeng Zhao, Jekaterina Jeromenok, Jens Weber and Helmut Schlaad

      Article first published online: 6 AUG 2012 | DOI: 10.1002/mabi.201200131

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      Chemical composition and structure affect the thermoresponsive aggregation behavior of linear triterpene–poly(ethylene oxide) block copolymers, thereby allowing for diversification in the sophisticated design of smart terpene-based biomaterials.

    12. Poly(ethylene imine)s as Antimicrobial Agents with Selective Activity (pages 1279–1289)

      Katherine A. Gibney, Iva Sovadinova, Analette I. Lopez, Michael Urban, Zachary Ridgway, Gregory A. Caputo and Kenichi Kuroda

      Article first published online: 3 AUG 2012 | DOI: 10.1002/mabi.201200052

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      Unmodified poly(ethylene imine)s are shown to act as selective antibacterial agents. The mechanism of action is likely related to, but not exclusive to, interaction with cell walls and cell membrane damage. These molecules provide a cost effective and chemically facile framework for the further development of selective antimicrobial materials.

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