Macromolecular Bioscience

Cover image for Vol. 13 Issue 3

March 2013

Volume 13, Issue 3

Pages 265–387

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      Macromol. Biosci. 3/2013 (page 265)

      Chang-Soo Lee, Hee Hyun Chang, Pan-Kee Bae, Juyeon Jung and Bong Hyun Chung

      Version of Record online: 20 MAR 2013 | DOI: 10.1002/mabi.201370008

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      Front Cover: Core-shell nanoparticles formed from a hydrophobic, fluorescent polymer and super-paramagnetic iron oxide are favorable for use in magnetic separation and guiding applications, as well as optical and magnetic resonance imaging capabilities. Chemical conjugation of the surface using folic acid molecules can provide them with cell-targeting properties, localizing them to folate receptors (FRs) on target KB (human nasopharyngeal carcinoma) cells that over-express the FRs. Further details can be found in the article by C.-S. Lee, H. H. Chang, P.-K. Bae, J. Y. Jung, and B. H. Chung* on page 321.

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      Macromol. Biosci. 3/2013 (page 266)

      Version of Record online: 20 MAR 2013 | DOI: 10.1002/mabi.201370009

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      Macromol. Biosci. 3/2013 (pages 267–270)

      Version of Record online: 20 MAR 2013 | DOI: 10.1002/mabi.201370010

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    1. Design Strategies and Applications of Tissue Bioadhesives (pages 271–288)

      Mohammadreza Mehdizadeh and Jian Yang

      Version of Record online: 6 DEC 2012 | DOI: 10.1002/mabi.201200332

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      Tissue adhesives have been developed into an effective and essential tool for bleeding control and wound healing and also gained increased attention in tissue engineering, and drug delivery. This paper provides a technical overview of structure, adhesion mechanisms, applications, and limitations of existing tissue adhesives and provides outlooks on future developments.

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    1. Biocompatible Fibrous Networks of Cellulose Nanofibres and Collagen Crosslinked Using Genipin: Potential as Artificial Ligament/Tendons (pages 289–298)

      Aji P. Mathew, Kristiina Oksman, Dorothée Pierron and Marie-Françoise Harmand

      Version of Record online: 6 DEC 2012 | DOI: 10.1002/mabi.201200317

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      Fully biobased nanocomposite materials developed from a double network of collagen and nanocellulose fibrils, embedded in collagen matrix and crosslinked in situ using genipin, show mechanical performance similar to that of natural ligaments and tendons. The materials show excellent biocompatibility and potential to be used as ligament/tendon substitutes.

    2. Human Mesenchymal Stem-Cell Behaviour On Direct Laser Micropatterned Electrospun Scaffolds with Hierarchical Structures (pages 299–310)

      Huaqiong Li, Yee Shan Wong, Feng Wen, Kee Woei Ng, Gary Ka Lai Ng, Subbu S. Venkatraman, Freddy Yin Chiang Boey and Lay Poh Tan

      Version of Record online: 11 DEC 2012 | DOI: 10.1002/mabi.201200318

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      Controllable myogenic differentiation of human mesenchymal stem cells is achieved by femtosecond laser machined micropatterns on electrospun scaffolds in the absence of soluble factors. The laser-induced homogenous patterns can direct cell orientation, support healthy cell growth, and promote lineage-specific myogenic differentiation of the stem cells.

    3. Effect of Silk Protein Processing on Drug Delivery from Silk Films (pages 311–320)

      Eleanor M. Pritchard, Xiao Hu, Violet Finley, Catherine K. Kuo and David L. Kaplan

      Version of Record online: 24 JAN 2013 | DOI: 10.1002/mabi.201200323

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      Duration of degumming used in preparing silk fibroin biopolymer protein impacts several critical material properties relevant to the use of silk in biomedical applications. Increased degumming time decreases the average molecular weight of silk protein in solution, silk solution viscosity, and silk film glass-transition temperature, and increases the rate of degradation of silk film by protease and the rate of model compound diffusion through silk films.

    4. Bifunctional Nanoparticles Constructed Using One-Pot Encapsulation of a Fluorescent Polymer and Magnetic (Fe3O4) Nanoparticles in a Silica Shell (pages 321–331)

      Chang-Soo Lee, Hee Hyun Chang, Pan-Kee Bae, Juyeon Jung and Bong Hyun Chung

      Version of Record online: 27 DEC 2012 | DOI: 10.1002/mabi.201200308

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      Bifunctional nanoparticles (PDDF/Fe3O4@SiO2) composed of a fluorescent polymer and Fe3O4 nanoparticles are developed for use as highly photostable nano-biomaterials. Greater photostability, low cytotoxicity, high cellular uptake, and accumulation efficiency, together with cancer-targeted specific internalization, are demonstrated.

    5. Degradable Poly(amidoamine) Hydrogels as Scaffolds for In Vitro Culturing of Peripheral Nervous System Cells (pages 332–347)

      Nicolò Mauro, Amedea Manfredi, Elisabetta Ranucci, Patrizia Procacci, Michele Laus, Diego Antonioli, Cristina Mantovani, Valerio Magnaghi and Paolo Ferruti

      Version of Record online: 13 DEC 2012 | DOI: 10.1002/mabi.201200354

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      Poly(amidoamine) hydrogels based on piperazine and 1,4-bis(acryloyl)piperazine are robust in the swollen state due to crystalline domains acting as self-reinforcing agents and promote Schwann and dorsal root ganglia neuron proliferation. Their combination of properties is seldom found in synthetic scaffolds for peripheral nerve cell culturing.

    6. Scaffold Effects on Osteogenic Differentiation of Equine Mesenchymal Stem Cells: An In Vitro Comparative Study (pages 348–355)

      Rodolfo Nino-Fong, Laurie A. McDuffee, Blanca P. Esparza Gonzalez, M. Ramesh Kumar, Erika F. Merschrod S. and Kristin M. Poduska

      Version of Record online: 18 JAN 2013 | DOI: 10.1002/mabi.201200355

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      Stem-cell-based therapy is an important strategy in the treatment of organ and tissue injuries. This study indicates that a collagen-based scaffold supports osteogenic differentiation in vitro, promising results for possible treatments in regenerative medicine.

    7. Nano-hydroxyapatite Surfaces Grafted with Electroactive Aniline Tetramers for Bone-Tissue Engineering (pages 356–365)

      Yadong Liu, Haitao Cui, Xiuli Zhuang, Peibiao Zhang, Yi Cui, Xianhong Wang, Yen Wei and Xuesi Chen

      Version of Record online: 1 FEB 2013 | DOI: 10.1002/mabi.201200345

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      An electroactive inorganic-organic hybrid material, aniline tetramer (AT)-grafted nano-hydroxyapatite (HA) (HA-AT), is synthesized using a silane coupling agent. The hybrid material exhibits excellent electroactivity and non-toxicity. Moreover, the inorganic-organic hybrid material HA-AT can uniformly disperse into the HA-AT/PLA composites, compared with HA in HA/PLA composites. The electroactive HA-AT hybrid materials can be useful in the future, to make electroactive HA-AT/polymer composites for tissue regeneration.

    8. Mimicking Native Extracellular Matrix with Phytic Acid-Crosslinked Protein Nanofibers for Cardiac Tissue Engineering (pages 366–375)

      Rajeswari Ravichandran, Vera Seitz, Jayarama Reddy Venugopal, Radhakrishnan Sridhar, Subramanian Sundarrajan, Shayanti Mukherjee, Erich Wintermantel and Seeram Ramakrishna

      Version of Record online: 18 JAN 2013 | DOI: 10.1002/mabi.201200391

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      A novel technique for crosslinking natural polymers using phytic acid is discussed. The ability of mesenchymal stem cells (MSCs) cultured on these crosslinked hemoglobin/gelatin/fibrinogen nanofibrous scaffolds to undergo cardiogenic differentiation is demonstrated. Such scaffolds are capable of inducing cell adhesion, proliferation and functional differentiation of MSCs, and thus may prove to be a prognostic device for treatment of myocardial infarction.

    9. Bacteriophages as Templates for Manufacturing Supramolecular Structures (pages 376–387)

      Nuriye Korkmaz, Young Jun Kim and Chang Hoon Nam

      Version of Record online: 20 NOV 2012 | DOI: 10.1002/mabi.201200290

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      The P8 coat protein of fd phages is genetically modified to obtain fd-p8SSGDD phages. These carry less net negative surface charge than wild-type fd. The effect of surface charges on phage bundling efficiency is studied at different cation concentrations. High-resolution AFM and SEM pictures provide valuable information on how nanosized phages align to form microscale bundles.

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