Macromolecular Bioscience

Cover image for Vol. 13 Issue 4

April 2013

Volume 13, Issue 4

Pages 389–523

  1. Cover Picture

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    1. You have free access to this content
      Macromol. Biosci. 4/2013 (page 389)

      Jin-Lei Wang, Ke-Feng Ren, Hao Chang, Fan Jia, Bo-Chao Li, Ying Ji and Jian Ji

      Article first published online: 18 APR 2013 | DOI: 10.1002/mabi.201370011

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      Front Cover: Mussel-inspired poly(dopamine) coating can directly facilitate attachment, spreading, and phenotypic maintenance of human umbilical vein endothelial cells (HUVECs) without any help of additional extracellular matrix (ECM) proteins. Endogenous fibronectin and α5β1 integrin play important roles in the cell adhesion process. Further details can be found in the article by J.-L. Wang, K.-F. Ren,* H. Chang, F. Jia, B.-C. Li, Y. Ji, and J. Ji* on page 483.

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    1. Macromol. Biosci. 4/2013 (page 390)

      Article first published online: 18 APR 2013 | DOI: 10.1002/mabi.201370012

  3. Contents

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    1. Macromol. Biosci. 4/2013 (pages 391–394)

      Article first published online: 18 APR 2013 | DOI: 10.1002/mabi.201370013

  4. Review

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    1. Polysaccharides and Their Derivatives for Versatile Tissue Engineering Application (pages 395–421)

      Ferdous Khan and Sheikh Rafi Ahmad

      Article first published online: 19 MAR 2013 | DOI: 10.1002/mabi.201200409

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      Functional biomaterials derived from various polysaccharides such as chitin and chitosan, hyaluronic acid, alginate, starch, and cellulose are reviewed; from their fundamental chemical derivatization to advanced 3D scaffolds fabrication for a variety of tissue engineering applications.

  5. Full Papers

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    1. A Serum-Resistant Low-Generation Polyamidoamine with PEI 423 Outer Layer for Gene Delivery Vector (pages 422–436)

      Shirong Pan, Duanwen Cao, Huan Huang, Wu Yi, Linhao Qin and Min Feng

      Article first published online: 4 FEB 2013 | DOI: 10.1002/mabi.201200255

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      The preparation of new derivatives of PAMAM and PEI (G2.5-PEI 423 and G1.5-PEI 423) and the evaluation of their physico-chemical and biological properties is reported. The G2.5-PEI 423 displays lower cytotoxicity, enhanced transfection efficiency, and better serum-resistant capacity, and has a great potential to be used for an efficient gene vector.

    2. Polymers for the Cell-Specific Immobilisation of Megakaryocytic Cell Lines (pages 437–443)

      Anne Hansen, Samuel Corless, Alexander Cleland, Juraj Petrik, Nick Gilbert and Mark Bradley

      Article first published online: 18 FEB 2013 | DOI: 10.1002/mabi.201200368

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      By applying polymer microarray technology, polymers that selectively bind MEG-01 cells are identified, which offer the opportunity for the enrichment of megakaryocytic cells prior to stem cell therapy. Analysis via flow cytometry and miRNA studies reveals only minor changes in maturation state upon immobilisation of the cells.

    3. In Vivo Biological Responses to Silk Proteins Functionalized with Bone Sialoprotein (pages 444–454)

      Sílvia Gomes, Jabier Gallego-Llamas, Isabel B. Leonor, João F. Mano, Rui L. Reis and David L. Kaplan

      Article first published online: 28 JAN 2013 | DOI: 10.1002/mabi.201200372

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      The in vivo response to a new chimeric protein, 6mer + BSP, is evaluated, since implantation initiates a wound-healing process through an inflammation response. This bioengineered silk-bone silaoprotein is implanted subcutaneously to the 6mer + BSP films and the inflammatory response is compared with the reactions against control films, genetically engineered spider-like silk alone, and PLGA control films, as well as empty implant sites.

    4. Improvement of Nanoprecipitation Technique for Preparation of Gelatin Nanoparticles and Potential Macromolecular Drug Loading (pages 455–463)

      Saeed Ahmad Khan and Marc Schneider

      Article first published online: 20 FEB 2013 | DOI: 10.1002/mabi.201200382

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      Nanocarriers for the delivery of hydrophilic drugs such as macromolecules are prepared. An improvement of the nanoprecipitation technique is reported for gelatin nanoparticles. The effects of various parameters involved in the particle formation process are investigated. The loading and release of a model hydrophilic macromolecule is studied to explore the potential of gelatin nanoparticles as a nanomaterial for the encapsulation of macromolecules.

    5. An Anti-angiogenic Reverse Thermal Gel as a Drug-Delivery System for Age-Related Wet Macular Degeneration (pages 464–469)

      Daewon Park, Veeral Shah, Britta M. Rauck, Thomas R. Friberg and Yadong Wang

      Article first published online: 11 JAN 2013 | DOI: 10.1002/mabi.201200384

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      An injectable and biodegradable reverse thermal gel, ESHU, is capable of sustaining the release of bevacizumab over 17 weeks in vitro. ESHU is not toxic to ocular cell types, demonstrating its potential as an intravitreal drug-delivery system.

    6. Mild Oxidation of Thiofunctional Polymers to Cytocompatible and Stimuli-Sensitive Hydrogels and Nanogels (pages 470–482)

      Smriti Singh, Ilona Zilkowski, Andrea Ewald, Tobias Maurell-Lopez, Krystyna Albrecht, Martin Möller and Jürgen Groll

      Article first published online: 7 FEB 2013 | DOI: 10.1002/mabi.201200389

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      Alloxan, a mild alternative to hydrogen peroxide, is introduced as an oxidation catalyst for the coupling of thiomers to redox-sensitive nanogels with a tunable size between 150 and 350 nm. These data comprise particle stability under physiological conditions but degradation in cytosolic conditions using glutathione (GSH) as a reducing agent, as well as cytocompatibility in concentrations up to 10 mg · mL−1.

    7. Direct Adhesion of Endothelial Cells to Bioinspired Poly(dopamine) Coating Through Endogenous Fibronectin and Integrin α5β1 (pages 483–493)

      Jin-Lei Wang, Ke-Feng Ren, Hao Chang, Fan Jia, Bo-Chao Li, Ying Ji and Jian Ji

      Article first published online: 7 MAR 2013 | DOI: 10.1002/mabi.201200390

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      A bioinspired poly(dopamine) coating can directly promote attachment and spreading of endothelial cells under serum-free conditions. The poly(dopamine) coating facilitates the adsorption and assembly of endogenous fibronectin co-localizing with α5β1 integrin, by which cell adhesion is triggered.

    8. Hollow Multilayer Microcapsules for pH-/Thermally Responsive Drug Delivery using Aliphatic Poly(urethane-amine) as Smart Component (pages 494–502)

      Jun Shi, Chao Du, Jin Shi, Yaming Wang and Shaokui Cao

      Article first published online: 18 FEB 2013 | DOI: 10.1002/mabi.201200411

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      Hollow microcapsules made of aliphatic PUA and PSS are prepared for smart drug delivery. DOX release behavior demonstrate that the drug release of microcapsules increase with decreasing pH value due to the interaction weakness between PUA and PSS. The drug release at 55 °C is higher than that at 37 °C for the shrinkage of PUA above its lower critical solution temperature (LCST).

    9. PEG-Modified Macroporous Poly(Glycidyl Methacrylate) and Poly(2-Hydroxyethyl Methacrylate) Microspheres to Reduce Non-Specific Protein Adsorption (pages 503–511)

      Helena Hlídková, Daniel Horák, Vladimír Proks, Zdenka Kučerová, Michal Pekárek and Jan Kučka

      Article first published online: 28 JAN 2013 | DOI: 10.1002/mabi.201200446

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      Modification of macroporous poly(glycidyl methacrylate) and poly(2-hydroxyethyl methacrylate) microspheres containing amino and/or carboxyl groups with α,ω-bis-carboxy poly(ethylene glycol), amino-terminated poly(ethylene glycol-co-propylene glycol), or α-methoxy-ω-amino poly(ethylene glycol) substantially reduces non-specific protein/enzyme adsorption.

    10. A Serum-Tolerant Hydroxyl-Modified Polyethylenimine as Versatile Carriers of pDNA/siRNA (pages 512–522)

      Xuan Dong, Lin Lin, Jie Chen, Zhaopei Guo, Huayu Tian, Yuce Li, Yen Wei and Xuesi Chen

      Article first published online: 8 JAN 2013 | DOI: 10.1002/mabi.201200346

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      A series of serum-tolerant PTn conjugates, by introduction of hydroxyl groups onto PEI25k, is designed as dual carriers for nucleic acids delivery. The transfection efficiency of PTn can be up to 29.1–fold higher than that of PEI25k in the serum-containing medium. Meanwhile, PTn with higher endocytosis is more effective in luciferase knockdown compared to PEI25k in the serum-containing medium.

  6. Correction

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Review
    6. Full Papers
    7. Correction
    1. You have free access to this content
      Human Elastin-Based Recombinant Biopolymers Improve Mesenchymal Stem Cell Differentiation (page 523)

      Betül Çelebi, Maxime Cloutier, Rodrigo B. Rabelo, Diego Mantovani and Antonella Bandiera

      Article first published online: 18 APR 2013 | DOI: 10.1002/mabi.201370014

      This article corrects:

      Human Elastin-Based Recombinant Biopolymers Improve Mesenchymal Stem Cell Differentiation

      Vol. 12, Issue 11, 1546–1554, Article first published online: 5 OCT 2012

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