Macromolecular Bioscience

Cover image for Vol. 13 Issue 6

June 2013

Volume 13, Issue 6

Pages 669–816

  1. Cover Picture

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    3. Masthead
    4. Contents
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      Macromol. Biosci. 6/2013 (page 669)

      Hyun-Ouk Kim, Eunjung Kim, Yonghee An, Jihye Choi, Eunji Jang, Eun Bi Choi, Aastha Kukreja, Myeong-Hoon Kim, Byunghoon Kang, Dong-Joo Kim, Jin-Suck Suh, Yong-Min Huh and Seungjoo Haam

      Version of Record online: 18 JUN 2013 | DOI: 10.1002/mabi.201370018

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      Front Cover: Bcl-xL siRNA and DOX encapsulated polymersomes (CPSomes) are synthesized using amphiphilic methoxy-poly(ethylene glycol)-block-poly(lactic acid) copolymers to enhance the stability and delivery efficacy of their contents. Successful delivery of drugs and genes by CPSomes shows its potential as a dual delivery vehicle for cancer treatment. Further details can be found in the article by H.-O. Kim, E. Kim, Y. An, J. Choi, E. Jang, E. B. Choi, A. Kukreja, M.-H. Kim, B. Kang, D.-J. Kim, J.-S. Suh, Y.-M. Huh,* and S. Haam* on page 745.

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      Macromol. Biosci. 6/2013 (page 670)

      Version of Record online: 18 JUN 2013 | DOI: 10.1002/mabi.201370019

  3. Contents

    1. Top of page
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    3. Masthead
    4. Contents
    5. Communications
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      Macromol. Biosci. 6/2013 (pages 671–675)

      Version of Record online: 18 JUN 2013 | DOI: 10.1002/mabi.201370020

  4. Communications

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    1. Patterning Surfaces for Controlled Platelet Adhesion and Detection of Dysfunctional Platelets (pages 676–681)

      Wei Ye, Qiang Shi, Shing-Chung Wong, Jianwen Hou, Hengchong Shi and Jinghua Yin

      Version of Record online: 18 APR 2013 | DOI: 10.1002/mabi.201200463

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      A patterned surface is fabricated based on controlled surface-initiated polymerization of monomer and degradation of the obtained polymer at the UV-exposed domains on the polymer surface with UV irradiation. Switching on and off of platelet adhesion on the polymer surface is realized with a precision down to single cell level. The dysfunctional platelets can be quantitatively detected based on the adhesive pattern.

    2. Influence of Spacer Length on the Cellular Uptake of Polymeric Nanoparticles (pages 682–686)

      Frank Thielbeer, Emma M. V. Johansson, Sunay V. Chankeshwara and Mark Bradley

      Version of Record online: 21 MAY 2013 | DOI: 10.1002/mabi.201200455

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      The influence of varying the length of the spacer, attached to polymer nanoparticles, on the formation of a protein corona and cellular uptake are studied. Although the composition of the protein corona is not affected by different spacer lengths, an influence on cellular uptake can be identified.

  5. Full Papers

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    1. Gelatin-Alginate Gels and Their Enzymatic Modifications: Controlling the Delivery of Small Molecules (pages 687–695)

      Marie-Cécile Klak, Elodie Lefebvre, Laure Rémy, Rémy Agniel, Julien Picard, Sébastien Giraudier and Véronique Larreta-Garde

      Version of Record online: 19 FEB 2013 | DOI: 10.1002/mabi.201200386

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      The use of various gelatin gels containing alginate as a molecular delivery system is described. The concept, development and use of several protein-polysaccharide architectures to retain very small molecules and control their release is described. The strategy presented here resides in the use of enzymes to hydrolyze one of the two phases of the gel in a highly controlled way.

    2. Mimicking Nanofibrous Hybrid Bone Substitute for Mesenchymal Stem Cells Differentiation into Osteogenesis (pages 696–706)

      Chinnasamy Gandhimathi, Jayarama Venugopal, Rajeswari Ravichandran, Subramanian Sundarrajan, Shanmugavel Suganya and Seeram Ramakrishna

      Version of Record online: 25 MAR 2013 | DOI: 10.1002/mabi.201200435

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      Biocompatible polycaprolactone/poly(α,β)-DL-aspartic acid/collagen nanofibrous scaffolds are fabricated by electrospinning, and nanohydroxyapatite (n-HA) is deposited by a calcium phosphate dipping method. These scaffolds are characterized for fiber morphology, hydrophilicity, porosity, and tensile properties. Mesenchymal stem cell (MSC) cultures on these nanofibrous scaffolds facilitate cell adhesion, proliferation, mineralization, and osteogenic differentiation.

    3. Multifunctional Hybrid Materials From Poly(3-Hydroxybutyrate), TiO2 Nanoparticles, and Chitosan Oligomers by Combining Electrospinning/Electrospraying and Impregnation (pages 707–716)

      Elena Korina, Olya Stoilova, Nevena Manolova and Iliya Rashkov

      Version of Record online: 25 MAR 2013 | DOI: 10.1002/mabi.201200410

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      Nanofibrous materials from poly(3-hydroxybutyrate), titanium dioxide nanoparticles, and COS are fabricated by an effective approach, consisting of electrospinning, electrospraying, and impregnation. The mats exhibit photocatalytic properties and a biocidal effect against pathogenic bacteria, and moreover, they provide a favorable environment for hMSCs.

    4. Impact of DNA Sequence and Oligonucleotide Length on a Polythiophene-Based Fluorescent DNA Biosensor (pages 717–722)

      Isabelle Charlebois, Catherine Gravel, Naoual Arrad, Maurice Boissinot, Michel G. Bergeron and Mario Leclerc

      Version of Record online: 19 MAR 2013 | DOI: 10.1002/mabi.201200469

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      The sequence composition is critical for DNA conformation and can impair its use as a recognition mechanism in biosensing applications. Repeated sequence patterns such as polyT or PolyC, although similar, generate different sensor conformations when mixed with a polythiophene derivative DNA hybridization sensor. Knowledge of the impact of DNA sequences on biosensors can help improving biosensing systems.

    5. Poloxamine–Cyclodextrin–Simvastatin Supramolecular Systems Promote Osteoblast Differentiation of Mesenchymal Stem Cells (pages 723–734)

      Susana M. N. Simões, Francisco Veiga, Juan J. Torres-Labandeira, Ana Cristina F. Ribeiro, Angel Concheiro and Carmen Alvarez-Lorenzo

      Version of Record online: 22 APR 2013 | DOI: 10.1002/mabi.201300017

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      Osteogenic syringeable gels exploit the capability of osteoinductive poloxamine Tetronic 908 to form polypseudorotaxanes with αCD and to solubilize and sustainably release the simvastatin hydroxy acid form for synergic differentiation of mesenchymal stem cells to osteoblasts. αCD transforms dilute poloxamine/simvastatin dispersions into affordable osteogenic/osteoinductive networks that can be administered using minimally invasive techniques for local treatment of bone pathologies.

    6. Folate-Conjugated PEG on Single Walled Carbon Nanotubes for Targeting Delivery of Doxorubicin to Cancer Cells (pages 735–744)

      Lvye Niu, Lingjie Meng and Qinghua Lu

      Version of Record online: 24 APR 2013 | DOI: 10.1002/mabi.201200475

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      A folate-conjugated PEG coating on single walled carbon nanotubes is developed in a facile strategy that can target delivery of the anti-cancer drug, doxorubicin, into cancer cells and effectively induce cancer cell death, but shows negligible cytotoxicity to normal cells.

    7. A Biodegradable Polymersome Containing Bcl-xL siRNA and Doxorubicin as a Dual Delivery Vehicle for a Synergistic Anticancer Effect (pages 745–754)

      Hyun-Ouk Kim, Eunjung Kim, Yonghee An, Jihye Choi, Eunji Jang, Eun Bi Choi, Aastha Kukreja, Myeong-Hoon Kim, Byunghoon Kang, Dong-Joo Kim, Jin-Suck Suh, Yong-Min Huh and Seungjoo Haam

      Version of Record online: 23 APR 2013 | DOI: 10.1002/mabi.201200448

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      Successful delivery of small molecular drugs and therapeutic genes by Bcl-xL siRNA and doxorubicin (DOX) encapsulated polymersomes shows potential as a highly powerful nanocarrier-based dual therapy system for cancer treatment.

    8. In Vitro Evaluation of Combined Sulfated Silk Fibroin Scaffolds for Vascular Cell Growth (pages 755–766)

      Haifeng Liu, Xili Ding, Yanxue Bi, Xianghui Gong, Xiaoming Li, Gang Zhou and Yubo Fan

      Version of Record online: 22 APR 2013 | DOI: 10.1002/mabi.201200470

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      In order to develop small-diameter vascular grafts that have excellent hemocompatibility to prevent platelet adhesion and aggregation on the scaffold surface and simultaneously be suitable for vascular cell growth, a combined sulfated silk fibroin scaffold is fabricated by modifying a knitted silk scaffold with sulfated silk fibroin sponges. The scaffold may greatly improve the chances of successful vascular reconstruction.

    9. Tunable Properties of Inclusion Complexes Between Amylose and Polytetrahydrofuran (pages 767–776)

      Rachmawati Rachmawati, Albert J. J. Woortman and Katja Loos

      Version of Record online: 22 APR 2013 | DOI: 10.1002/mabi.201300022

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      Amylose and polytetrahydrofuran (PTHF) can form inclusion complexes that are able to self-assemble to form supramolecules. Amylose, with its hydrophobic cavity, acts as host molecule and PTHF acts as guest molecule. The resulting complexes induce the formation of the so-called V-amylose, which is influenced by the arrangements of the guest PTHF chains inside or in between the amylose helices.

    10. In Vitro and In Vivo Enzyme-Mediated Biomineralization of Oligo(poly(ethylene glycol) Fumarate Hydrogels (pages 777–788)

      Matilde Bongio, M. Reza Nejadnik, Z. Tahmasebi Birgani, Pamela Habibovic, Lucas A. Kinard, F. Kurtis Kasper, Antonios G. Mikos, John A. Jansen, Sander C. G. Leeuwenburgh and Jeroen J. J. P. van den Beucken

      Version of Record online: 10 APR 2013 | DOI: 10.1002/mabi.201200474

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      Hydrogels are highly hydrated polymers with structural properties similar to soft tissues. In view of bone regenerative applications, the incorporation of alkaline phosphatase (ALP) within hydrogels is a simple and promising strategy to generate scaffolds with both an organic and inorganic phase. Specifically, the enzymatic hydrolysis of organic phosphates, diffused from the physiological environment, leads to the formation of minerals.

    11. The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells (pages 789–798)

      Zhao Zhang, Qianqian Qu, Jinrong Li and Shaobing Zhou

      Version of Record online: 17 APR 2013 | DOI: 10.1002/mabi.201300037

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      Besides factors such as particle size, morphology, and surface charge, the hydrophilic/hydrophobic ratio of the micelle matrix also has a great effect on cellular uptake of micelles. The internalization of micelles with different hydrophilic/hydrophobic ratio into cells is through different endocytosis mechanisms.

    12. A Generic Micropatterning Platform to Direct Human Mesenchymal Stem Cells from Different Origins Towards Myogenic Differentiation (pages 799–807)

      Ting Yu, Chee Kai Chua, Chor Yong Tay, Feng Wen, Haiyang Yu, Jerry K. Y. Chan, Mark S. K. Chong, David Tai Leong and Lay Poh Tan

      Version of Record online: 19 APR 2013 | DOI: 10.1002/mabi.201200481

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      The capability of a micropatterning platform in modulating cell shape to direct lineage commitment of human mesenchymal stem cells derived from different sources (i.e., bone marrow, fetal tissue, and adipose) is investigated. Myogenesis is shown to be the predominant differentiation activity at mRNA and protein levels in three types of micropatterned stem cells. The platform is thus demonstrated to be generic and could possibly be extended to any type of stem cell.

    13. A Dual Enzyme Microgel with High Antioxidant Ability Based on Engineered Seleno-Ferritin and Artificial Superoxide Dismutase (pages 808–816)

      Yuzhou Gao, Chunxi Hou, Lipeng Zhou, Dongmei Zhang, Chunqiu Zhang, Lu Miao, Liang Wang, Zeyuan Dong, Quan Luo and Junqiu Liu

      Version of Record online: 19 APR 2013 | DOI: 10.1002/mabi.201300019

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      A dual enzyme microgel is constructed based on the covalent crosslinking of Mn-THPP-(PEG2000-BA)4 and seleno-ferritin (Se-Fn). The microgel exhibits excellent antioxidative activity in the protection of mitochondria against oxidative stress and lipid peroxidation due to the synergism of the MnIII porphyrin (SOD mimic) and Se-Fn (GPx mimic).

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