Osteogenetic Properties of Electrospun Nanofibrous PCL Scaffolds Equipped With Chitosan-Based Nanoreservoirs of Growth Factors (pages 45–55)
Alice Ferrand, Sandy Eap, Ludovic Richert, Stéphanie Lemoine, Deepak Kalaskar, Sophie Demoustier-Champagne, Hassan Atmani, Yves Mély, Florence Fioretti, Guy Schlatter, Liisa Kuhn, Guy Ladam and Nadia Benkirane-Jessel
Article first published online: 19 AUG 2013 | DOI: 10.1002/mabi.201300283
Nanofibrous scaffolds of poly-ϵ-caprolactone are rendered osteogenetic by incorporation of BMP-2 growth factor. The layer-by-layer method is implemented to combine FDA-approved BMP-2 and chitosan within the form of fish scale-like nanoreservoirs covering the nanofibers. The osteoconductive potential of the scaffolds is demonstrated both in vitro and in vivo, opening a route toward efficient bone regeneration at reduced risk and cost level.