Macromolecular Bioscience

Cover image for Vol. 14 Issue 10

October 2014

Volume 14, Issue 10

Pages 1355–1505

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Communication
    7. Full Papers
    8. Correction
    1. You have free access to this content
      Cover Picture: Macromol. Biosci. 10/2014 (page 1355)

      Philipp Heller, Alexander Birke, David Huesmann, Benjamin Weber, Karl Fischer, Angelika Reske-Kunz, Matthias Bros and Matthias Barz

      Article first published online: 14 OCT 2014 | DOI: 10.1002/mabi.201470035

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      Front Cover: A series of well-defined polypeptide-polypeptoid block copolymers based on the body's own amino acids sarcosine and lysine are prepared by K. Fischer, M. Bros, M. Barz, and co-workers on page 1380 by ring opening polymerization of N-carboxyanhydrides. The obtained block ionomers are used to complex pDNA resulting in the formation of polyplexes (PeptoPlexes). The PeptoPlexes can be successfully applied in the transfection of HEK293T cells and are able to transfect up to 50% of cells in vitro (FACS assay), while causing no detectable toxicity in an Annexin V assay. These findings are a first indication that PeptoPlexes may be a suitable alternative to PEG based non-viral transfection systems.

  2. Back Cover

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Communication
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    8. Correction
    1. Back Cover: Macromol. Biosci. 10/2014 (page 1506)

      Hanno Schieferstein, Annette Kelsch, Achim Reibel, Kaloian Koynov, Matthias Barz, Hans-Georg Buchholz, Nicole Bausbacher, Oliver Thews, Rudolf Zentel and Tobias L. Ross

      Article first published online: 14 OCT 2014 | DOI: 10.1002/mabi.201470038

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      Back Cover: On page 1396 R. Zentel, T. L. Ross, and coworkers report the synthesis of a 10.5 kDa and a 52.5 kDa polymer, based on pHPMA functionalized with tyramine for 18F-labeling and a folate derivative as targeting moiety. The cover image depicts the synthesis, radiolabeling, and the successful application of the active targeting approach in tumor bearing rats using the 18F-labeled folate-HPMA conjugates. The conjugation of folate results in an increased tumor accumulation compared to non-targeted polymers.

  3. Masthead

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
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    1. Masthead: Macromol. Biosci. 10/2014 (page 1356)

      Article first published online: 14 OCT 2014 | DOI: 10.1002/mabi.201470036

  4. Contents

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Communication
    7. Full Papers
    8. Correction
    1. Contents: Macromol. Biosci. 10/2014 (pages 1357–1360)

      Article first published online: 14 OCT 2014 | DOI: 10.1002/mabi.201470037

  5. Communication

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Communication
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    1. Zwitterionic Red Fluorescent Polymeric Nanoparticles for Cell Imaging (pages 1361–1367)

      Haiyin Li, Xiqi Zhang, Xiaoyong Zhang, Bin Yang, Yang Yang, Zengfang Huang and Yen Wei

      Article first published online: 13 JUN 2014 | DOI: 10.1002/mabi.201400223

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      Cross-linked zwitterionic red fluorescent copolymers are fabricated by incorporating phospholipid monomer and aggregation-induced emission dye-based dimer via reversible addition–fragmentation transfer polymerization. These cross-linked polymers are easy to self-assembly into uniform nanoparticles that show high water dispersibility, intense red fluorescence, and excellent biocompatibility, making them promising for cell imaging applications.

  6. Full Papers

    1. Top of page
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    3. Back Cover
    4. Masthead
    5. Contents
    6. Communication
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    8. Correction
    1. Protease-Sensitive PEG Hydrogels Regulate Vascularization In Vitro and In Vivo (pages 1368–1379)

      Marina Vigen, Jacob Ceccarelli and Andrew J. Putnam

      Article first published online: 18 JUN 2014 | DOI: 10.1002/mabi.201400161

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      Co-encapsulation of endothelial cells and supportive fibroblasts within proteolyzable poly(ethylene glycol) (PEG)-based hydrogels leads to vascular morphogenesis in vitro that is robust to changes in crosslinking peptide identity but is significantly attenuated by gel crosslinking and MMP inhibition. In vivo, perfused vasculature forms from transplanted cells in all gel types, and vascularization is not attenuated in more crosslinked gels.

    2. Introducing PeptoPlexes: Polylysine-block-Polysarcosine Based Polyplexes for Transfection of HEK 293T Cells (pages 1380–1395)

      Philipp Heller, Alexander Birke, David Huesmann, Benjamin Weber, Karl Fischer, Angelika Reske-Kunz, Matthias Bros and Matthias Barz

      Article first published online: 18 JUN 2014 | DOI: 10.1002/mabi.201400167

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      The synthesis, characterization, and application of polypeptide-polypeptoid block copolymers and polyplexes thereof based on the body's own amino acids sarcosine and lysine are presented. The pathway to PLys-block-PSar and the use of the synthesized block ionomers for the formation of polyplexes (PeptoPlexes) and for first transfection studies in HEK 293T cells are described.

    3. 18F-Radiolabeling, Preliminary Evaluation of Folate-pHPMA Conjugates via PET (pages 1396–1405)

      Hanno Schieferstein, Annette Kelsch, Achim Reibel, Kaloian Koynov, Matthias Barz, Hans-Georg Buchholz, Nicole Bausbacher, Oliver Thews, Rudolf Zentel and Tobias L. Ross

      Article first published online: 4 AUG 2014 | DOI: 10.1002/mabi.201400200

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      For two new 18F-labeled pHPMA copolymers, which are functionalized with folate units, active targeting can be proved in vivo (Walker carcinoma) by blockade studies.

    4. Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier (pages 1406–1414)

      Zhaopei Guo, Huayu Tian, Lin Lin, Jie Chen, Chaoliang He, Zhaohui Tang and Xuesi Chen

      Article first published online: 20 JUN 2014 | DOI: 10.1002/mabi.201400044

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      Successful gene therapy for cancer and various human genetic diseases treatment relies on high efficient gene carriers. But for most carriers, either DNA or RNA can be effectively delivered. Here, amphiphilic copolymers polyethylenimine-polyalanine, with good biocompatibility, are prepared for high efficient transfection both in DNA and RNA.

    5. Star-Shape Redox-Responsive PEG-Sheddable Copolymer of Disulfide-Linked Polyethylene Glycol-Lysine-di-Tocopherol Succinate for Tumor-Triggering Intracellular Doxorubicin Rapid Release: Head-to-Head Comparison (pages 1415–1428)

      Xiaoyu Ai, Jin Sun, Lu Zhong, Chunnuan Wu, Handong Niu, Tao Xu, He Lian, Xiaopeng Han, Guolian Ren, Wenya Ding, Jia Wang, Xiaohui Pu and Zhonggui He

      Article first published online: 20 JUN 2014 | DOI: 10.1002/mabi.201400149

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      Self-assembled redox-responsive nanomicelles are endocytosed into tumor cells. Then, disulfide bonds in micelles are cleaved and poly(ethylene glycol) (PEG) hydration shell is shed, induced by the high glutathione concentration. The nanomicelles are disassembled and the loaded doxorubicin (DOX) is released into the plasma and translocates into the nucleus to exert its anticancer effect.

    6. Synthesis of Functionalized Poly(ester carbonate) with Laminin-Derived Peptide for Promoting Neurite Outgrowth of PC12 cells (pages 1429–1436)

      Dongming Xing, Lie Ma and Changyou Gao

      Article first published online: 25 JUN 2014 | DOI: 10.1002/mabi.201400186

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      Laminin-derived peptide functionalized poly(ester carbonate) (PEC) is synthesized to promote neurite outgrowth of PC12 cells. The maleimide-functionalized PECs are clicked with various thiol-containing molecules. The CQAASIKVAV-grafted PEC could support cell proliferation and neurite outgrowth. Therefore, the maleimide-functionalized PECs can serve as a versatile platform for diverse functionalization and have comprehensive potential in biomedical applications.

    7. Enzymatic Synthesis of Dendritic Amphoteric α-Glucans by Thermostable Phosphorylase Catalysis (pages 1437–1443)

      Yusei Takata, Riko Shimohigoshi, Kazuya Yamamoto and Jun-Ichi Kadokawa

      Article first published online: 30 JUN 2014 | DOI: 10.1002/mabi.201400204

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      Enzymatic synthesis of dendritic amphoteric α-glucans having both glucuronic acid and glucosamine residues at the non-reducing ends is performed by phosphorylase catalysis, which shows inherent isoelectric points and assembling/disassembling behaviors in water in accordance of the pH values.

    8. Toward Anticancer Immunotherapeutics: Well-Defined Polymer–Antibody Conjugates for Selective Dendritic Cell Targeting (pages 1444–1457)

      Kristof Tappertzhofen, Monika Bednarczyk, Kaloian Koynov, Matthias Bros, Stephan Grabbe and Rudolf Zentel

      Article first published online: 30 JUN 2014 | DOI: 10.1002/mabi.201400190

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      The synthesis of multifunctionalizable semitelechelic maleimide-modifided HPMA based polymers of narrow dispersity that can be conjugated to anti-DEC-205 antibodies affording “star-like” topologies is described. Primary in vitro studies show their high potential to target dendritic cells (DCs). This opens the opportunity to present tumor antigens to DCs and thus to induce antitumor immune responses.

    9. Cell–Microsphere Constructs Formed with Human Adipose-Derived Stem Cells and Gelatin Microspheres Promotes Stemness, Differentiation, and Controlled Pro-Angiogenic Potential (pages 1458–1468)

      Anjaneyulu Kodali, Thiam Chye Lim, David Tai Leong and Yen Wah Tong

      Article first published online: 1 JUL 2014 | DOI: 10.1002/mabi.201400094

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      Three-dimensional cell–microsphere constructs formed with gelatin microspheres are found to be suitable platforms for the growth and differentiation of adipose-derived stem cells (ADSCs). These constructs also tend to preserve the stemness properties of the ADSCs along with enhancing their pro-angiogenic properties.

    10. Hybrid Polyglycerols with Long Blood Circulation: Synthesis, Biocompatibility, and Biodistribution (pages 1469–1482)

      Muhammad Imran ul-haq, Benjamin F. L. Lai and Jayachandran N. Kizhakkedathu

      Article first published online: 11 JUL 2014 | DOI: 10.1002/mabi.201400152

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      Hybrid polyglycerols (inline image ≈ 100 kDa) with different compositions (15–80 mol% linear polyglycerol) with excellent blood and cell compatibility are synthesized. The polymers show long blood circulation with minimal organ accumulation in mice and are attractive for the development of multifunctional drug delivery systems.

    11. Bioreducible Branched Polyethyleneimine Derivatives Physically Loaded with Hydrophobic Pheophorbide A: Preparation, Characterization, and Light-Induced Cytotoxicity (pages 1483–1494)

      Hana Cho, Li Li, You Han Bae, Kang Moo Huh and Han Chang Kang

      Article first published online: 1 AUG 2014 | DOI: 10.1002/mabi.201400145

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      Branched types of polyethyleneimine (bPEI) derivatives can load hydrophobic photosensitizers in neutral or basic pH-tuned hydrophobic cavities. However, drug release from bPEI derivatives is not activated by acidic pH but by cytosol-specific triggered biodegradation. This mechanism results in light-mediated cytotoxic effects when photosensitizer-loaded reducible bPEI derivatives are used that are not seen when non-reducible bPEI derivatives are used.

    12. Nanoparticle/Polymer Assembled Microcapsules with pH Sensing Property (pages 1495–1504)

      Pan Zhang, Xiaoxue Song, Weijun Tong and Changyou Gao

      Article first published online: 1 AUG 2014 | DOI: 10.1002/mabi.201400259

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      The dual-labeled microcapsules via nanoparticle/polymer assembly based on polyamine–salt aggregates are fabricated for the ratiometric intracellular pH sensing. The microcapsules are internalized by several kinds of cells naturally, and after being internalized they are all located in acidic organelles. Negatively charged drugs are easily encapsulated into capsules.

  7. Correction

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Communication
    7. Full Papers
    8. Correction
    1. You have free access to this content
      18F-Radiolabeling, Preliminary Evaluation of Folate-pHPMA Conjugates via PET (page 1505)

      Hanno Schieferstein, Annette Kelsch, Achim Reibel, Kaloian Koynov, Matthias Barz, Hans-Georg Buchholz, Nicole Bausbacher, Oliver Thews, Rudolf Zentel and Tobias L. Ross

      Article first published online: 14 OCT 2014 | DOI: 10.1002/mabi.201400431

      This article corrects:

      18F-Radiolabeling, Preliminary Evaluation of Folate-pHPMA Conjugates via PET1

      Vol. 14, Issue 10, 1396–1405, Article first published online: 4 AUG 2014

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