Macromolecular Bioscience

Cover image for Vol. 14 Issue 4

April 2014

Volume 14, Issue 4

Pages 451–597

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Review
    6. Communications
    7. Full Papers
    8. Corrigendum
    1. Cover Picture: Macromol. Biosci. 4/2014 (page 451)

      Gi Hyun Choi, Hong Jae Lee and Sang Cheon Lee

      Article first published online: 15 APR 2014 | DOI: 10.1002/mabi.201470013

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      Front Cover: Resistance to corrosion, excellent biocompatibility, and superb mechanical strength make titanium (Ti) one of most suitable metals to build many medical devices. On page 496, a catechol-functionalized polymer nanoparticle that can spontaneously adhere to Ti surface is developed. The nanoparticle has three domains: i) a hydrophobic biodegradable polymer core, ii) an anionic hyaluronic acid shell that can load positively charged dual osteogenic proteins, and iii) surface-exposed catechol groups. Sang Cheon Lee and colleagues show how this nanoparticle can be adopted for various applications as a good model of surface controlled releasing systems.

  2. Masthead

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Review
    6. Communications
    7. Full Papers
    8. Corrigendum
    1. Masthead: Macromol. Biosci. 4/2014 (page 452)

      Article first published online: 15 APR 2014 | DOI: 10.1002/mabi.201470014

  3. Contents

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Review
    6. Communications
    7. Full Papers
    8. Corrigendum
    1. Contents: Macromol. Biosci. 4/2014 (pages 453–457)

      Article first published online: 15 APR 2014 | DOI: 10.1002/mabi.201470015

  4. Review

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Review
    6. Communications
    7. Full Papers
    8. Corrigendum
    1. Polymer Micro- and Nanocapsules as Biological Carriers with Multifunctional Properties (pages 458–477)

      Anna Musyanovych and Katharina Landfester

      Article first published online: 10 MAR 2014 | DOI: 10.1002/mabi.201300551

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      A considerable research has been conducted in recent years on development of multifunctional polymer capsules with controlled chemical composition and physical properties. This Review discusses different types of bio-oriented polymer-based colloidal systems, emphasizing on formulation aspects, site-specific drug targeting, and controlled release of a “payload” upon applying of external stimulus.

  5. Communications

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Review
    6. Communications
    7. Full Papers
    8. Corrigendum
    1. Novel On-Demand Bioadhesion to Soft Tissue in Wet Environments (pages 478–484)

      Vishal Mogal, Vladislav Papper, Alok Chaurasia, Gao Feng, Robert Marks and Terry Steele

      Article first published online: 2 DEC 2013 | DOI: 10.1002/mabi.201300380

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      A novel diazirine-based bioadhesive that can be applied across various clinically important surfaces is developed. After plasma post-irradiation on PLGA films, on-demand and tuneable bioadhesion is demonstrated on ex vivo swine aorta soft tissues. The non-optimized bioadhesive strength is stronger than many hydrogel bioadhesives while having superior material properties. The poly-diazirine surface grafted thin films could allow expansion onto previously developed technologies for minimally invasive surgeries.

    2. A Smart Drug Delivery System from Charge-Conversion Polymer–Drug Conjugate for Enhancing Tumor Therapy and Tunable Drug Release (pages 485–490)

      Hailong Huang, Yapeng Li, Zongpeng Sa, Yuan Sun, Yuzhen Wang and Jingyuan Wang

      Article first published online: 15 APR 2014 | DOI: 10.1002/mabi.201300337

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      A smart drug delivery system shows dual-pH sensitive properties: extracellular pH-triggered enhanced endocytosis and intracellular pH-triggered drug release.

    3. Electrostatically Driven Complexation of Liposomes with a Star-Shaped Polyelectrolyte to Low-Toxicity Multi-Liposomal Assemblies (pages 491–495)

      Alexander A. Yaroslavov, Andrey V. Sybachin, Olga V. Zaborova, Dmitry V. Pergushov, Alexander B. Zezin, Nikolay S. Melik-Nubarov, Felix A. Plamper, Axel H. E. Müller and Frederic M. Menger

      Article first published online: 15 NOV 2013 | DOI: 10.1002/mabi.201300436

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      Adsorption of anionic liposomes on star-shaped cationic polyelectrolyte results in formation of multi-liposomal electrostatical complex. The retention of the liposomal integrity after adsorption and stability of complexes towards dissociation in physiological water-salt media makes it promising for creation high-capacity carrier for the delivery of biological active substances.

  6. Full Papers

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Review
    6. Communications
    7. Full Papers
    8. Corrigendum
    1. Titanium-Adhesive Polymer Nanoparticles as a Surface-Releasing System of Dual Osteogenic Growth Factors (pages 496–507)

      Gi Hyun Choi, Hong Jae Lee and Sang Cheon Lee

      Article first published online: 12 NOV 2013 | DOI: 10.1002/mabi.201300368

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      Titanium-adhesive nanoparticles, that can be strongly immobilized on Ti surfaces and release dual osteogenic growth factors, are developed as a novel surface-releasing system. The Ti substrates with dual growth factor-loaded nanoparticle-immobilized nanoparticles remarkably promote the attachment, proliferation, spreading, and alkaline phosphatase activity of human adipose-derived stem cells.

    2. Therapeutic Strategies to Prevent Alzheimer's Disease Pathogenesis Using A Fluorescent Conjugated Polyelectrolyte (pages 508–514)

      Atul K. Dwivedi and Parameswar K. Iyer

      Article first published online: 8 JUL 2013 | DOI: 10.1002/mabi.201300107

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      A conceptually important therapeutic strategy to reduce neurotoxicity and prevent Alzheimer's disease pathogenesis involving the inhibition and clearance of amyloid β fibrils, removal of neurotoxic metals, and preventing aggregation of the peptides again in brain plaques using an anionic-water-soluble polyfluorene derivative is presented.

    3. Gold Nanoparticle Loaded Hybrid Nanofibers for Cardiogenic Differentiation of Stem Cells for Infarcted Myocardium Regeneration (pages 515–525)

      Rajeswari Ravichandran, Radhakrishnan Sridhar, Jayarama Reddy Venugopal, Subramanian Sundarrajan, Shayanti Mukherjee and Seeram Ramakrishna

      Article first published online: 11 DEC 2013 | DOI: 10.1002/mabi.201300407

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      A novel therapeutic Au nanoparticles loaded PVA/BSA nanofibers is discussed in the present study for infarcted myocardium regeneration. These scaffolds can be used to improve the functional activity of differentiated MSCs by increasing the gap junction protein, connexin 43 (Cx43). This approach opens the frontiers for creating functional cardiac patch with desirable properties for enhanced cardiac regeneration.

    4. Acidity-Promoted Cellular Uptake and Drug Release Mediated by Amine-Functionalized Block Polycarbonates Prepared via One-Shot Ring-Opening Copolymerization (pages 526–536)

      Hua-Fen Wang, Hui-Zhen Jia, Yan-Feng Chu, Jun Feng, Xian-Zheng Zhang and Ren-Xi Zhuo

      Article first published online: 25 NOV 2013 | DOI: 10.1002/mabi.201300414

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      Controllable ring-opening block copolymerization of amino-functionalized PADMC-b-PTeMC block copolycarbonates in the “one-shot feeding” pathway and the fabrication of their core–shell nanomicelles are reported. The pH-dependent deprotonation-to-protonation transition of PADMC shell allows a selective control over both the cellular uptake and the drug release pattern, in response to acidic microenvironments such as tumor sites.

    5. Blocked Bacteria Escape by ATRP Grafting of a PMMA Shell on PVA Microparticles (pages 537–545)

      Christian Knierim, Charles L. Greenblatt, Seema Agarwal and Andreas Greiner

      Article first published online: 29 NOV 2013 | DOI: 10.1002/mabi.201300398

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      The escape of immobilized bacteria from hydrogel microparticles is prevented by water stable core–shell composites. Therefore, a surface initiated ATRP of MMA at room temperature is employed to obtain a hydrophobic PMMA shell. However, the viability of the immobilized bacteria is demonstrated afterwards. The core–shell architecture is examined by the copolymerization of FMA and MMA and by TEM.

    6. Fabrication of Novel Reduction-Sensitive Gene Vectors Based on Three-Armed Peptides (pages 546–556)

      Qi Lei, Yun-Xia Sun, Si Chen, Si-Yong Qin, Hui-Zhen Jia, Ren-Xi Zhuo and Xian-Zheng Zhang

      Article first published online: 11 DEC 2013 | DOI: 10.1002/mabi.201300422

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      Two reduction-sensitive branched polypeptides (RBPs) are reported as non-viral gene vectors. The RBPs exhibit remarkably enhanced gene transfection with much reduced cytotoxicity. This highly branched reduction-sensitive polypeptide shows great potential for gene delivery.

    7. Development of P22 Viral Capsid Nanocomposites as Anti-Cancer Drug, Bortezomib (BTZ), Delivery Nanoplatforms (pages 557–564)

      Junseon Min, Hyojin Moon, Hyun Ji Yang, Hyun-Hee Shin, Sung You Hong and Sebyung Kang

      Article first published online: 2 JAN 2014 | DOI: 10.1002/mabi.201300401

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      P22 viral capsid-based multifunctional delivery nanocomposites are constructed using both genetic and chemical manipulations. P22 viral capsid nanocomposites show an excellent capability to encapsulate an anti-cancer drug, BTZ, through boronic acid-diol complexation and to deliver it to the target hepatocellular carcinoma cells with the aid of the targeting ligands on their surface.

    8. Biodegradable, pH-Responsive Carboxymethyl Cellulose/Poly(Acrylic Acid) Hydrogels for Oral Insulin Delivery (pages 565–575)

      Xiaoye Gao, Yue Cao, Xiangfu Song, Zhe Zhang, Xiuli Zhuang, Chaoliang He and Xuesi Chen

      Article first published online: 19 DEC 2013 | DOI: 10.1002/mabi.201300384

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      Biodegradable, pH-responsive carboxymethyl cellulose/poly(acrylic acid) hydrogels are synthesized. Insulin is selectively released in neutral intestinal environment from insulin-loaded hydrogels, rendering markedly enhanced oral bioavailability of insulin-loaded gels compared to free insulin solution in animal tests.

    9. Self-Assembling Stereocomplex Nanoparticles by Enantiomeric Poly(γ-glutamic acid)-poly(lactide) Graft Copolymers as a Protein Delivery Carrier (pages 576–587)

      Ye Zhu, Takami Akagi and Mitsuru Akashi

      Article first published online: 19 DEC 2013 | DOI: 10.1002/mabi.201300434

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      Stereocomplex nanoparticles with different size and degree of crystallinity are composed by the equal molar mixture of enantiomeric poly(γ-glutamic acid)-poly(lactide) graft copolymers. The nanoparticles can effectively be loaded with proteine and peptide by using both surface immobilization or encapsulation methods. Meanwhile, stereocomplex NPs have strong kinetic stability and can be expected to serve as stable delivery vehicles for pharmaceutical and biomedical applications.

    10. Co-Delivery of Oxaliplatin and Demethylcantharidin via a Polymer–Drug Conjugate (pages 588–596)

      Enhui Wang, Hejian Xiong, Dongfang Zhou, Zhigang Xie, Yubin Huang, Xiabin Jing and Xinhua Sun

      Article first published online: 20 NOV 2013 | DOI: 10.1002/mabi.201300402

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      A polymer-(tandem drugs) conjugate system is used to deliver oxaliplatin and demethylcantharidin (DMC) for combination chemotherapy. This polymer–drug conjugate with dual cancer killing modes can self-assemble into micelles and be stable in plasma but responsively release drugs in cancer cells. In vitro evaluation shows that the polymer–drug conjugate micelles with reduced toxicity display enhanced cytotoxicity against SKOV-3 cells compared to corresponding pro-drug.

  7. Corrigendum

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Review
    6. Communications
    7. Full Papers
    8. Corrigendum
    1. You have free access to this content
      Glycol Chitosan-Based Nanogel as a Potential Targetable Carrier for siRNA (page 597)

      Paula Pereira, Daniela Morgado, Agnès Crepet, Laurent David and Francisco M. Gama

      Article first published online: 15 APR 2014 | DOI: 10.1002/mabi.201400150

      This article corrects:

      Glycol Chitosan-Based Nanogel as a Potential Targetable Carrier for siRNA

      Vol. 13, Issue 10, 1369–1378, Article first published online: 28 AUG 2013

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