Macromolecular Bioscience

Cover image for Vol. 14 Issue 7

July 2014

Volume 14, Issue 7

Pages 901–1051

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Feature Article
    6. Communications
    7. Full Papers
    1. Cover Picture: Macromol. Biosci. 7/2014 (page 901)

      Myeong-Hoon Kim, Bongjune Kim, Eun-Kyung Lim, Yuna Choi, Jihye Choi, Eunjung Kim, Eunji Jang, Hyo Seon Park, Jin-Suck Suh, Yong-Min Huh and Seungjoo Haam

      Article first published online: 15 JUL 2014 | DOI: 10.1002/mabi.201470025

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      Front Cover: Oleyl dextran-coated magnetic nanoclusters (ODMCs) are synthesized by Y.-M. Huh, S. Haam, and colleagues via polymer-controlled self-assembly to be served for sensitive MR imaging of atherosclerosis. Sufficient diagnostic capability of ODMCs for imaging of atherosclerotic plaques is successfully demonstrated on page 943 by the cellular imaging of macrophages and in vivo MR imaging of rat artery balloon injury model.

  2. Masthead

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Feature Article
    6. Communications
    7. Full Papers
    1. Masthead: Macromol. Biosci. 7/2014 (page 902)

      Article first published online: 15 JUL 2014 | DOI: 10.1002/mabi.201470026

  3. Contents

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Feature Article
    6. Communications
    7. Full Papers
    1. Contents: Macromol. Biosci. 7/2014 (pages 903–907)

      Article first published online: 15 JUL 2014 | DOI: 10.1002/mabi.mabi201470027

  4. Feature Article

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Feature Article
    6. Communications
    7. Full Papers
    1. Bioreducible Polycations in Nucleic Acid Delivery: Past, Present, and Future Trends (pages 908–922)

      David Oupický and Jing Li

      Article first published online: 28 MAR 2014 | DOI: 10.1002/mabi.201400061

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      This Feature Article provides an overview of the current status of research into the chemistry of bioreducible polycations and their use in nucleic acid delivery.

  5. Communications

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Feature Article
    6. Communications
    7. Full Papers
    1. Microsphere-Based Intracellular Sensing of Caspase-3/7 in Apoptotic Living Cells (pages 923–928)

      Juan Manuel Cárdenas-Maestre, Ana M. Pérez-López, Mark Bradley and Rosario M. Sánchez-Martín

      Article first published online: 25 MAR 2014 | DOI: 10.1002/mabi.201300525

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      Monitoring enzymatic activity inside living cells. A novel probe for the detection of a particular enzymatic activity intracellularly in living cells are successfully developed. In particular, the applicability of these microspheres for sensing caspase-3/7 enzymatic activity in living cells by flow cytometry is reported.

    2. Fluorescent Amphiphilic PEG-Peptide-PEG Triblock Conjugate Micelles for Cell Imaging (pages 929–935)

      Tapas K. Paira, Anupam Saha, Sanjib Banerjee, Tamalika Das, Pradip Das, Nikhil R. Jana and Tarun K. Mandal

      Article first published online: 31 MAR 2014 | DOI: 10.1002/mabi.201400083

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      A blue fluorescent amphiphilic poly(ethylene glycol)-peptide-fluorophore-peptide-poly(ethylene glycol) triblock conjugate is synthesized by “grafting to” technique based on Schiff base coupling chemistry, which undergo self-assembly in water to from micelles. The highly stable and low toxic conjugate micelles are used for fluorescent imaging of HeLa cells.

    3. Glycopolymer Functionalization of Engineered Spider Silk Protein-based Materials for Improved Cell Adhesion (pages 936–942)

      John G. Hardy, André Pfaff, Aldo Leal-Egaña, Axel H. E. Müller and Thomas R. Scheibel

      Article first published online: 2 APR 2014 | DOI: 10.1002/mabi.201400020

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      Recombinantly produced spider silk protein-based materials are promising for use as tissue scaffolds. Herein, the preparation of films functionalized with extracellular matrix protein-binding glycopolymers, and their potential as biocompatible coatings, are reported.

  6. Full Papers

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Feature Article
    6. Communications
    7. Full Papers
    1. Magnetic Nanoclusters Engineered by Polymer-Controlled Self-Assembly for the Accurate Diagnosis of Atherosclerotic Plaques via Magnetic Resonance Imaging (pages 943–952)

      Myeong-Hoon Kim, Bongjune Kim, Eun-Kyung Lim, Yuna Choi, Jihye Choi, Eunjung Kim, Eunji Jang, Hyo Seon Park, Jin-Suck Suh, Yong-Min Huh and Seungjoo Haam

      Article first published online: 17 APR 2014 | DOI: 10.1002/mabi.201400029

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      Oleyl dextran (ODex) coated magnetic nanocluster (ODMC) is developed and engineered by polymer-controlled self-assembly to be used as efficient MR imaging nanoprobe of atherosclerosis. T2 relaxivity of ODMCs is highly enhanced by controlling the condition of ODex including the degree of substitution of the oleyl group and the concentration used for the synthesis of ODMCs.

    2. Cell Behavior on Surface Modified Polydimethylsiloxane (PDMS) (pages 953–964)

      Morgan M. Stanton, Johanna M. Rankenberg, Byung-Wook Park, W. Grant McGimpsey, Christopher Malcuit and Christopher R. Lambert

      Article first published online: 6 MAR 2014 | DOI: 10.1002/mabi.201300504

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      A biochemical micro-pattern is successfully combined with a micro-rough polymer surface as a scaffold to mimic in vivo environments for tissue engineering. Cells cultured on the modified polymer exhibit alignment and significantly altered gene expression. This novel substrate has useful applications for complex tissue design and biomimetic scaffolds.

    3. Electrospun Micelles/Drug-Loaded Nanofibers for Time-Programmed Multi-Agent Release (pages 965–976)

      Guang Yang, Jie Wang, Long Li, Shan Ding and Shaobing Zhou

      Article first published online: 13 MAR 2014 | DOI: 10.1002/mabi.201300575

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      A nanoscale multi-drug delivery system, whose release behavior shows a time-programmed release and can be temporally and spatially controlled for each cargo, is fabricated based on polymer micelle-enriched electrospun nanofibers. The combination of multiple agents possesses great potential in improving the efficiency of cancer chemotherapy compared with only one therapeutic agent.

    4. Poly(hydroxybutyrate-co-hydroxyvalerate) Bilayer Skin Tissue Engineering Constructs with Improved Epidermal Rearrangement (pages 977–990)

      Alessandra Zonari, Mariana T. Cerqueira, Silviene Novikoff, Alfredo M. Goes, Alexandra P. Marques, Vitor M. Correlo and Rui L. Reis

      Article first published online: 4 MAR 2014 | DOI: 10.1002/mabi.201400005

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      Taking in consideration skin two main strata, epidermis and dermis, a bilayer structure based on poly(hydroxybutyrate-co-hydroxyvalerate) is developed, combining a 2D thin nanoporous upper layer and a 3D scaffold. The bilayer system favors human fibroblasts and keratinocytes performance under defined co-culture conditions and leads to the particular rearrangement of human keratinocytes in a multilayer structure.

    5. Enzymatic Mineralization of Silk Scaffolds (pages 991–1003)

      Sangram K. Samal, Mamoni Dash, Heidi A. Declercq, Tom Gheysens, Jolien Dendooven, Pascal Van Der Voort, Ria Cornelissen, Peter Dubruel and David L. Kaplan

      Article first published online: 7 MAR 2014 | DOI: 10.1002/mabi.201300513

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      Alkaline phosphatase-mediated formation of apatitic minerals on porous silk protein (SFP) scaffolds. The mineral structures differ as a function of ALP concentration. The mineralized SFP scaffolds are effective in improving cellular adhesion, proliferation, and colonization by osteogenic cells.

    6. Enzymatic Control of Chitosan Gelation for Delivery of Periodontal Ligament Cells (pages 1004–1014)

      Xiang-Zhen Yan, Arnold W. G. Nijhuis, Jeroen J. J. P. van den Beucken, Sanne K. Both, John A. Jansen, Sander C. G. Leeuwenburgh and Fang Yang

      Article first published online: 31 MAR 2014 | DOI: 10.1002/mabi.201400040

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      Physically crosslinked chitosan hydrogels for biomedical purpose can be easily fabricated via enzymatic control. The gelation time, strength, and degradation rate of chitosan hydrogels can be fine-tuned through variation of the concentrations of urea and urease. Periodontal ligament cells remain viable and maintain their capacities upon encapsulation within these hydrogels for up to 30 days.

    7. Synthesis and Characterization of Homopolymers Bearing Acid-Cleavable Cationic Side-Chains for pH-Modulated Release of DNA (pages 1015–1024)

      Zhangyan Xu, Junping Lai, Rupei Tang, Weihang Ji, Rui Wang, Jun Wang and Chun Wang

      Article first published online: 4 APR 2014 | DOI: 10.1002/mabi.201400004

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      A new mechanism of pH-modulated release of DNA from polymeric carrier (PMAOE) through a combination of cationic side-chain cleavage with increased polymer hydrophilicity and neutralization of residual cationic charges is demonstrated. These structurally simple side-chain degradable PMAOE homopolymers may have great potential as gene delivery vectors capable of releasing DNA in response to external or intracellular pH environment.

    8. Multiresponsive Hyaluronan-p(NiPAAm) “Click”-Linked Hydrogels (pages 1025–1038)

      Sharad K. Pasale, Barbara Cerroni, Shivkumar V. Ghugare and Gaio Paradossi

      Article first published online: 6 APR 2014 | DOI: 10.1002/mabi.201400021

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      Telechelic pNiPAAm chains, with controlled molecular weight, bearing alkyne functionalities at both chain ends, obtained by a novel modification of RAFT polymerization, and grafted hyaluronan backbones with side-chains ending with azido groups are crosslinked according to “click chemistry” protocols as monolithic hydrogels. The constructs display combined or separated responsivities to temperature, pH and ionic strength and are biodegradable. Proliferation is enhanced in the case of tumor cells.

    9. Sequential pH-Dependent Adsorption of Ionic Amphiphilic Diblock Copolymer Micelles and Choline Oxidase Onto Conductive Substrates: Toward the Design of Biosensors (pages 1039–1051)

      Larisa V. Sigolaeva, Ulrike Günther, Dmitry V. Pergushov, Snezhana Yu. Gladyr, Ilya N. Kurochkin and Felix H. Schacher

      Article first published online: 17 APR 2014 | DOI: 10.1002/mabi.201300580

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      Block copolymer/enzyme biosensors are prepared via electrostatically driven co-assembly. Amphiphilic diblock copolymer micelles of poly(n-butylmethacrylate)-block-poly(N,N-dimethylaminoethyl methacrylate) and choline oxidase are used as building blocks to fabricate bilayer films on conductive substrates (modified graphite or gold) at different pH-values. The resulting hybrid thin-films represent highly active and stable biosensors for choline.

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