Macromolecular Bioscience

Cover image for Vol. 14 Issue 8

August 2014

Volume 14, Issue 8

Pages 1053–1198

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      Cover Picture: Macromol. Biosci. 8/2014 (page 1053)

      Guicai Li, Xueying Zhao, Luzhong Zhang, Caiping Wang, Yunwei Shi and Yumin Yang

      Article first published online: 18 AUG 2014 | DOI: 10.1002/mabi.201470028

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      Front Cover: To address the effect of chitosan micropatterning on nerve regeneration, two sizes of parallel microstripes of chitosan are fabricated by Y. Yang and co-workers on the surface of coverslips using a micromodeling method. The study presented on page 1067 suggests that chitosan micropatterning can induce and regulate the growth of SCs well, which may have potential application in peripheral nerve regeneration.

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    1. Masthead: Macromol. Biosci. 8/2014 (page 1054)

      Article first published online: 18 AUG 2014 | DOI: 10.1002/mabi.201470029

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    1. Contents: Macromol. Biosci. 8/2014 (pages 1055–1058)

      Article first published online: 18 AUG 2014 | DOI: 10.1002/mabi.201470030

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    1. Redox-Responsive Nanoparticles with Aggregation-Induced Emission (AIE) Characteristic for Fluorescence Imaging (pages 1059–1066)

      Weiren Cheng, Guan Wang, Xiaoyong Pan, Yong Zhang, Ben Zhong Tang and Ye Liu

      Article first published online: 28 APR 2014 | DOI: 10.1002/mabi.201400076

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      The nanoparticles with PEG shells and low cytotoxcity are fluorescent in intracellular compartments but non-fluorescent in extracellular matrix, therefore, to provide fluorescence imaging with a high contrast. Furthermore, the fluorescent intensity increases with the concentration of thiol, making it promising for differentiation of redox environment using fluorescence imaging.

    2. Regulating Schwann Cells Growth by Chitosan Micropatterning for Peripheral Nerve Regeneration In Vitro (pages 1067–1075)

      Guicai Li, Xueying Zhao, Luzhong Zhang, Caiping Wang, Yunwei Shi and Yumin Yang

      Article first published online: 23 APR 2014 | DOI: 10.1002/mabi.201400098

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      Most Schwann Cells (SCs) grow along well with the chitosan micropatterning on 30/30 µm sample, while some cells grow across the micropatterning on the 20/20 µm sample. The neurite of the SCs on the 30/30 µm sample present better ductility along the stripe structure than the 20/20 µm sample after culturing for 1 d.

    3. pH-Sensitive Chitosan-based Hydrogel Nanoparticles through Miniemulsion Polymerization Mediated by Peroxide Containing Macromonomer (pages 1076–1083)

      Nadiya Solomko, Olga Budishevska, Stanislav Voronov, Katharina Landfester and Anna Musyanovych

      Article first published online: 8 APR 2014 | DOI: 10.1002/mabi.201300512

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      The synthesis of cross-linked pH-sensitive hydrogel nanoparticles (HNp) based on free-radical graft copolymerization between peroxide-modified chitosan and 1-vinyl-2-pyrrolidone is reported. The formation of HNp with a size average 155–190 nm is achieved in the aqueous nanodroplets of inverse miniemulsion. Parameters such as cross-linking density, pH, and nature of ionic “payload” molecules greatly affect the swelling behavior and release profile from HNp.

    4. Electrospun Nanofiber Scaffolds and Plasma Polymerization: A Promising Combination Towards Complete, Stable Endothelial Lining for Vascular Grafts (pages 1084–1095)

      Houman Savoji, Afra Hadjizadeh, Marion Maire, Abdellah Ajji, Michael R. Wertheimer and Sophie Lerouge

      Article first published online: 17 APR 2014 | DOI: 10.1002/mabi.201300545

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      Electrospinning and plasma polymerization are combined to provide vascular graft scaffolds. These bear similarity to the extracellular matrix beneath the luminal endothelium, are mechanically compliant and biocompatible, and facilitate formation of a cofluent monolayer of endothelial cells on the lumen, one that is stable under static and shear-induced flow conditions.

    5. Polymeric Nanocarriers for siRNA Delivery to Murine Macrophages (pages 1096–1105)

      Diane C. Forbes and Nicholas A. Peppas

      Article first published online: 22 APR 2014 | DOI: 10.1002/mabi.201400027

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      This work investigates the interactions of a polycationic nanocarrier with siRNA and with RAW264.7 cells in order to better understand the capabilities and limitations of the carrier. The cross-linked, DEAEMA-based nanoparticles are synthesized using ARGET ATRP in a single-step reaction. The carriers efficiently bind siRNA and are internalized by cells for siRNA delivery.

    6. Overcoming Cancer Multidrug Resistance by Codelivery of Doxorubicin and Verapamil with Hydrogel Nanoparticles (pages 1106–1115)

      Ming Qin, Yong-Eun Koo Lee, Aniruddha Ray and Raoul Kopelman

      Article first published online: 28 APR 2014 | DOI: 10.1002/mabi.201400035

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      A new kind of hydrogel nanoparticles is developed as a delivery vehicle for codelivery of doxorubicin, an anti-cancer drug (affects DNA), and verapamil, a chemosensitizer (blocks efflux pump), to tumor cells, aiming at overcoming multidrug resistance.

    7. Multifunctional Poly(Vinyl Amine)s Bearing Azetidinium Groups: One Pot Preparation in Water and Antimicrobial Properties (pages 1116–1124)

      Subrata Chattopadhyay, Elisabeth Therese Heine, Helmut Keul and Martin Möller

      Article first published online: 29 APR 2014 | DOI: 10.1002/mabi.201300576

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      Post polymerization modification of poly(vinyl amine) in aqueous solution with hydrophobic and cationic reactive building blocks results in multifunctional antimicrobial polymers. These polymers with alkyl chains and azetidinium groups differentiate between microorganisms and mammalian cells.

    8. Human Epidermal Keratinocyte Cell Response on Integrin-Specific Artificial Extracellular Matrix Proteins (pages 1125–1134)

      Monica Suryana Tjin, Alvin Wen Choong Chua, Dong Rui Ma, Seng Teik Lee and Eileen Fong

      Article first published online: 2 MAY 2014 | DOI: 10.1002/mabi.201400015

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      Artificial extracellular matrix (aECM) proteins bearing integrin-specific cell binding domains are designed to enhance cell adhesion and growth of keratinocytes while maintaining their stem cell characteristics. The attachment of keratinocytes on aECM proteins is shown to be a specific interaction between integrins and the cell binding domains present within each construct. It is demonstrated that aECM proteins have potential for use as artificial skin substrates.

    9. Efficient Gene Carriers Composed of 2-Hydroxypropyl-β-Cyclodextrin, Ethanolamine-Functionalized Poly(glycidyl methacrylate), and Poly((2-dimethyl amino)ethyl methacrylate) by Combination of ATRP and Click Chemistry (pages 1135–1148)

      Yun Zhu, Xuefeng Zheng, Bingran Yu, Wantai Yang, Nana Zhao and Fujian Xu

      Article first published online: 2 MAY 2014 | DOI: 10.1002/mabi.201400062

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      An efficient copolymer gene vector composed of 2-hydroxypropyl-β-cyclodextrin, ethanolamine-functionalized poly(glycidyl methacrylate), and poly((2-dimethyl amino)ethyl methacrylate) is proposed via ATRP and click chemistry.

    10. Synthesis, Cellular Uptake, and Biodistribution of Whey-Rich Nanoparticles (pages 1149–1159)

      Xu Zhen, Xin Wang, Chenchen Yang, Qin Liu, Wei Wu, Baorui Liu and Xiqun Jiang

      Article first published online: 2 MAY 2014 | DOI: 10.1002/mabi.201400018

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      The cellular uptakes and penetration of DOX-loaded whey-PAA nanoparticles are observed in monolayer cells and 3D cellular model. The distribution of DOX-loaded whey-PAA nanoparticles in tumor-bearing mice is examined. The nanoparticles can penetrate 3D cellular model more deeply and well accumulated in the tumor site.

    11. Chitosan-coated Gold Nanorods for Cancer Therapy Combining Chemical and Photothermal Effects (pages 1160–1169)

      Ruiping Duan, Zhimin Zhou, Guanghao Su, Lingrong Liu, Man Guan, Bo Du and Qiqing Zhang

      Article first published online: 2 MAY 2014 | DOI: 10.1002/mabi.201300563

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      A novel type of nanocarrier is prepared from chitosan derivatives and gold nanorods. The nanocarriers exhibit high stability and may be useful for cancer therapy combining chemical and photothermal effects.

    12. Antimicrobial Polyurethane Thermosets Based on Undecylenic Acid: Synthesis and Evaluation (pages 1170–1180)

      Cristina Lluch, Braulio Esteve-Zarzoso, Albert Bordons, Gerard Lligadas, Juan C. Ronda, Marina Galià and Virginia Cádiz

      Article first published online: 6 MAY 2014 | DOI: 10.1002/mabi.201400017

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      Plant-derived polyurethanes with enhanced surface hydrophilicity coupled with antimicrobial property are prepared from methyl ester-containing polyurethane networks via aminolysis and subsequently iodine complexation.

    13. Mussel-Inspired Cell-Adhesion Peptide Modification for Enhanced Endothelialization of Decellularized Blood Vessels (pages 1181–1189)

      Jung Seung Lee, Kihong Lee, Sung-Hwan Moon, Hyung-Min Chung, Jun Hyup Lee, Soong Ho Um, Dong-Ik Kim and Seung-Woo Cho

      Article first published online: 16 MAY 2014 | DOI: 10.1002/mabi.201400052

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      Mussel-inspired catechol functionalization by polydopamine coating leads to efficient immobilization of cell adhesion peptides on decellularized blood vessel matrices. Peptide modification promotes adhesion, metabolic activity, and endothelial differentiation of human endothelial progenitor cells, which ultimately facilitates endothelialization of the decellularized matrices.

    14. Synergistic Effect of Dual-Functionalized Fibrous Scaffold with BCP and RGD Containing Peptide for Improved Osteogenic Differentiation (pages 1190–1198)

      Young Min Shin, Sun-Young Jo, Jong-Seok Park, Hui-Jeong Gwon, Sung In Jeong and Youn-Mook Lim

      Article first published online: 7 MAY 2014 | DOI: 10.1002/mabi.201400023

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      Appropriate bone regeneration is systemically regulated by bioceramics and biomolecules in the extracellular matrix. Multi-functional scaffolds are required for facilitating the bone regeneration. Herein, dual-functional fibrous scaffolds with biphasic calcium phosphate (BCP) and Arg–Gly–Asp (RGD) peptide are introduced for bone tissue engineering and the effect to hMSC behavior control is investigated.

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