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Macromolecular Bioscience

Cover image for Vol. 15 Issue 1

Special Issue: Peptide-based Materials for Nanomedicine

January 2015

Volume 15, Issue 1

Pages 1–145

Issue edited by: Neil Cameron, Tim Deming

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Editorial
    7. Reviews
    8. Full Papers
    9. Communications
    10. Full Papers
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      Cover Picture: Macromol. Biosci. 1/2015 (page 1)

      Yang Li, Boi Hoa San, Julian L. Kessler, Jin Hwan Kim, Qingguo Xu, Justin Hanes and Seungju Michael Yu

      Article first published online: 13 JAN 2015 | DOI: 10.1002/mabi.201570001

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      Front Cover: The caged collagen mimetic peptide (CMP) enables patterning of almost any synthetic or natural gelatin-containing matrix through a light-activated triple helix hybridization process. The technique presented by S. M. Yu and co-workers on page 52 is a useful tool to spatially control cell behaviors through CMP-conjugated biochemical cues for functionalizing tissue scaffolds.

  2. Back Cover

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    3. Back Cover
    4. Masthead
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      Back Cover: Macromol. Biosci. 1/2015 (page 146)

      Philipp Heller, Nicole Mohr, Alexander Birke, Benjamin Weber, Angelika Reske-Kunz, Matthias Bros and Matthias Barz

      Article first published online: 13 JAN 2015 | DOI: 10.1002/mabi.201570004

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      Back Cover: Mannose-bearing amphiphilic block copolypept-(o)ides (polypeptoide-block-polypeptide copolymers) selfassemble into multivalent PeptoMicelles and bind to mannose-binding receptors as expressed by dendritic cells. In the study by M. Barz and co-workers on page 63, mannosylated micelles show enhanced cell uptake in DC2.4 cells as well as in bone marrow-derived dendritic cells (BMDCs) compared to non-functionalized PeptoMicelles.

  3. Masthead

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      Masthead: Macromol. Biosci. 1/2015 (page 2)

      Article first published online: 13 JAN 2015 | DOI: 10.1002/mabi.201570002

  4. Contents

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    3. Back Cover
    4. Masthead
    5. Contents
    6. Editorial
    7. Reviews
    8. Full Papers
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      Contents: Macromol. Biosci. 1/2015 (pages 3–6)

      Article first published online: 13 JAN 2015 | DOI: 10.1002/mabi.201570003

  5. Editorial

    1. Top of page
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    4. Masthead
    5. Contents
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      Peptide-based Materials for Nanomedicine (pages 7–8)

      Neil Cameron and Tim Deming

      Article first published online: 13 JAN 2015 | DOI: 10.1002/mabi.201400499

  6. Reviews

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      Polymeric Anti-HIV Therapeutics (pages 9–35)

      Maarten Danial and Harm-Anton Klok

      Article first published online: 3 SEP 2014 | DOI: 10.1002/mabi.201400298

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      Anti-HIV therapeutics have enabled to improve the lives of many infected individuals and shifted the prognosis to a chronic but manageable disease. In parallel to the development of small molecule drug therapeutics, profound interest and efforts have been made to develop polymeric anti-HIV therapeutics. An overview of these macromolecular therapeutics is presented herein.

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      Elastin-Like Polypeptide Based Nanoparticles: Design Rationale Toward Nanomedicine (pages 36–51)

      Ferdinanda C. M. Smits, Bastiaan C. Buddingh, Mark B. van Eldijk and Jan C. M. van Hest

      Article first published online: 19 NOV 2014 | DOI: 10.1002/mabi.201400419

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      Elastin-like polypeptides (ELPs) are biocompatible, temperature responsive and can be made with high sequence control. This makes ELP-based materials very interesting for their use towards nanomedicine applications. Many ELP-based systems that show self-assembly into nanoparticles have been developed. This review will give an overview of the ELP-based block copolymers capable of nanoparticle formation and their design parameters.

  7. Full Papers

    1. Top of page
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      Non-Covalent Photo-Patterning of Gelatin Matrices Using Caged Collagen Mimetic Peptides (pages 52–62)

      Yang Li, Boi Hoa San, Julian L. Kessler, Jin Hwan Kim, Qingguo Xu, Justin Hanes and Seungju Michael Yu

      Article first published online: 4 DEC 2014 | DOI: 10.1002/mabi.201400436

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      A caged collagen mimetic peptide (CMPs) enables 2D and 3D photo-patterning of gelatin hydrogels as well as the creation of concentration gradients of CMPs. Photo-patterning of caged CMPs can be performed on almost any synthetic or natural gelatin-containing matrix to spatially control cell behaviors through CMP-conjugated biochemical cues. This technique is a great tool for functionalizing scaffolds for complex tissue formation.

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      Directed Interactions of Block Copolypept(o)ides with Mannose-binding Receptors: PeptoMicelles Targeted to Cells of the Innate Immune System (pages 63–73)

      Philipp Heller, Nicole Mohr, Alexander Birke, Benjamin Weber, Angelika Reske-Kunz, Matthias Bros and Matthias Barz

      Article first published online: 5 JAN 2015 | DOI: 10.1002/mabi.201400417

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      Polypeptoide-block-polypeptide copolymers (polypept(o)ides) have raised first attention as a versatile material for the next generation of nano-drug delivery systems. By the use of functional initiators, mannose-bearing block copolypept(o)ides (PSar-block-PGlu(OBn)) can be obtained, which self-assemble into multivalent PeptoMicelles. These mannosylated micelles can interact with mannose receptors as expressed by dendritic cells.

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      Glycosylated Star Polypeptides from NCA Polymerization: Selective Binding as a Function of Degree of Branching and Glycosylation (pages 74–81)

      Mark Byrne, Robert Mildner, Henning Menzel and Andreas Heise

      Article first published online: 15 OCT 2014 | DOI: 10.1002/mabi.201400371

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      Poly(glutamic acid) star polymers with up to 64 arms are synthesized via N-carboxy-anhydride (NCA) polymerization from dendritic initiators. Glycosylation affords star-shaped glyco- peptides with varying degrees of sugar conjugation. The secondary structure and the ability to selectively bind to lectin ConA is found to be dependent on sugar content and polymer structure, respectively.

  8. Communications

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      Combinatorial Screening for Specific Drug Solubilizers with Switchable Release Profiles (pages 82–89)

      Sebastian Wieczorek, Sara Vigne, Tiziana Masini, Daniela Ponader, Laura Hartmann, Anna K. H. Hirsch and Hans G. Börner

      Article first published online: 29 DEC 2014 | DOI: 10.1002/mabi.201400443

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      Tailored peptide–PEO-conjugates with switchable drug release profiles for solubilization of water-insoluble small-molecule drugs are selected by screening a combinatorial split and mix peptide library. A disulfide backbone linker moiety, cleavable in reductive environments, is incorporated in the peptide library for triggered releases of the cargo molecule. Drug payload, aggregate size, and drug activation kinetics are fine-tunable though changes in the carrier amino acid sequence.

  9. Full Papers

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    3. Back Cover
    4. Masthead
    5. Contents
    6. Editorial
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      Blending of Diblock and Triblock Copolypeptide Amphiphiles Yields Cell Penetrating Vesicles with Low Toxicity (pages 90–97)

      April R. Rodriguez, Uh-Joo Choe, Daniel T. Kamei and Timothy J. Deming

      Article first published online: 16 OCT 2014 | DOI: 10.1002/mabi.201400348

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      Diblock and triblock copolypeptides are blended to form vesicle populations with uniform compositions. Mixing of cationic and non-ionic amphiphiles in these vesicles give optimized properties of good cellular uptake while maintaining minimal cytotoxicity. Copolypeptide mixing is a promising strategy to provide useful functionality without requiring complicated synthesis procedures.

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      Clustered Nanocarriers: The Effect of Size on the Clustering of CCMV Virus-Like Particles With Soft Macromolecules (pages 98–110)

      Martijn Verwegen and Jeroen J. L. M. Cornelissen

      Article first published online: 12 NOV 2014 | DOI: 10.1002/mabi.201400326

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      Clusters of virus-like particles are potentially interesting biomaterials that can find application in drug delivery, imaging, etc. This clustering can be induced by positively charged macromolecules it is shown that the macromolecular topology in combination with the symmetry of the virus-like particle are crucial parameters.

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      Thermoresponsive Self-Assembly of Nanostructures from a Collagen-Like Peptide-Containing Diblock Copolymer (pages 111–123)

      Tianzhi Luo, Lirong He, Patrick Theato and Kristi L. Kiick

      Article first published online: 13 NOV 2014 | DOI: 10.1002/mabi.201400358

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      Well-defined vesicles with a diameter of approximately 100 nm are produced from temperature-triggered self-assembly from a collagen-like peptide containing thermoresponsive diblock conjugates, driven by the coil/globule conformational transition of the PDEGMEMA building block above its LCST. The incorporation of CLP domains in these nanostructures offers opportunities for the selective targeting of collagen-containing matrices.

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      Amphiphilic PEO-b-PBLG Diblock and PBLG-b-PEO-b-PBLG Triblock Copolymer Based Nanoparticles: Doxorubicin Loading and In Vitro Evaluation (pages 124–137)

      Dipti Kakkar, Silvia Mazzaferro, Julie Thevenot, Christophe Schatz, Anant Bhatt, Bilikere S. Dwarakanath, Harpal Singh, Anil K. Mishra and Sebastien Lecommandoux

      Article first published online: 29 DEC 2014 | DOI: 10.1002/mabi.201400451

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      Huisgen's 1,3-dipolar cycloaddition is used as a versatile approach to prepare amphiphilic block copolymers of PEO and PBLG, which result in spherical micelles (≈100 nm) capable of successfully entrapping the anticancer drug, doxorubicin. The efficacy of these drug-loaded micelles toward cellular uptake is proven by flow cytometry and fluorescence microscopy.

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      Block Copolypeptide Nanoparticles for the Delivery of Ocular Therapeutics (pages 138–145)

      Timo Stukenkemper, Anica Dose, Maria Caballo Gonzalez, Alexander J.J. Groenen, Sarah Hehir, Vanessa Andrés-Guerrero, Rocio Herrero Vanrell and Neil R. Cameron

      Article first published online: 17 DEC 2014 | DOI: 10.1002/mabi.201400471

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      Nanoparticles from amphiphilic block copolypeptides are loaded with the ocular drug dexamethasone. The block copolypeptides are synthesized by sequential polymerization of benzyl-protected glutamic acid and Z-protected lysine N-carboxyanhydrides (NCAs). Selective deprotection of the benzyl glutamate block yields amphiphilic block copolymers that self-assemble into nanoaprticles in aqueous solution. Drug release is almost complete after 16 d in aqueous solution at 37 °C.

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