Block Copolypeptide Nanoparticles for the Delivery of Ocular Therapeutics (pages 138–145)
Timo Stukenkemper, Anica Dose, Maria Caballo Gonzalez, Alexander J.J. Groenen, Sarah Hehir, Vanessa Andrés-Guerrero, Rocio Herrero Vanrell and Neil R. Cameron
Article first published online: 17 DEC 2014 | DOI: 10.1002/mabi.201400471
Nanoparticles from amphiphilic block copolypeptides are loaded with the ocular drug dexamethasone. The block copolypeptides are synthesized by sequential polymerization of benzyl-protected glutamic acid and Z-protected lysine N-carboxyanhydrides (NCAs). Selective deprotection of the benzyl glutamate block yields amphiphilic block copolymers that self-assemble into nanoaprticles in aqueous solution. Drug release is almost complete after 16 d in aqueous solution at 37 °C.