Fluorescent Phosphorus Dendrimer as a Spectral Nanosensor for Macrophage Polarization and Fate Tracking in Spinal Cord Injury (pages 1523–1534)
Antos Shakhbazau, Manoj Mishra, Tak-Ho Chu, Craig Brideau, Karen Cummins, Shigeki Tsutsui, Dzmitry Shcharbin, Jean-Pierre Majoral, Serge Mignani, Mireille Blanchard-Desce, Maria Bryszewska, V. Wee Yong, Peter K. Stys and Jan van Minnen
Article first published online: 14 JUL 2015 | DOI: 10.1002/mabi.201500150
Fluorescent phosphorus dendrimer is readily internalized and maintained by bone marrow-derived macrophages, making it a useful cytoplasmic tracer. Sensitivity of dendrimer emission profile to the macrophage physiological status generates distinct spectral phenotypes, a feature which may offer new strategies for targeted release of therapeutic cargos, and assist in tracing macrophage plasticity in longitudinal studies in vitro and in vivo.