Macromolecular Bioscience

Cover image for Vol. 15 Issue 3

March 2015

Volume 15, Issue 3

Pages 293–437

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Feature Articles
    7. Communications
    8. Full Papers
    9. Correction
    1. You have free access to this content
      Cover Picture: Macromol. Biosci. 3/2015 (page 293)

      Akihiro Nishiguchi, Michiya Matsusaki and Mitsuru Akashi

      Article first published online: 3 MAR 2015 | DOI: 10.1002/mabi.201570009

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      Front Cover: Heparin-based ECM nanofilms formed on living cells by layer-by-layer assembly induce cell-cell crosslinking through bio-molecular recognition between highly-sulfated polymers and membrane proteins. Cell aggregates display network structures of cells and the cell-cell crosslinking process leads to in vitro 3D-tissue construction with rich glycosaminoglycan. The cellular assembly technique presented by M. Akashi and co-workers on page 312 has potential for tissue engineering and intercellular signalling assay.

  2. Back Cover

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Feature Articles
    7. Communications
    8. Full Papers
    9. Correction
    1. Back Cover: Macromol. Biosci. 3/2015 (page 438)

      Chen Li, Weiguo Xu, Jianxun Ding, Ying Zhang, Jincheng Wang, Xiuli Zhuang and Xuesi Chen

      Article first published online: 3 MAR 2015 | DOI: 10.1002/mabi.201570012

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      Back Cover: On page 328 J. Ding, J. Wang, and co-workers present a doxorubicin-loaded polypeptide micelle with suitable uniform size, high loading efficiency, and durable release. The laden micelle selectively accumulates in tumor tissue and effectively inhibits the growth of osteosarcoma with improved security in vivo.

  3. Masthead

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Feature Articles
    7. Communications
    8. Full Papers
    9. Correction
    1. Masthead: Macromol. Biosci. 3/2015 (page 294)

      Article first published online: 3 MAR 2015 | DOI: 10.1002/mabi.201570010

  4. Contents

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Feature Articles
    7. Communications
    8. Full Papers
    9. Correction
    1. Contents: Macromol. Biosci. 3/2015 (pages 295–299)

      Article first published online: 3 MAR 2015 | DOI: 10.1002/mabi.201570011

  5. Feature Articles

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Feature Articles
    7. Communications
    8. Full Papers
    9. Correction
    1. Recent Advances in Nanoscale Bioinspired Materials (pages 300–311)

      Melik C. Demirel, Murat Cetinkaya, Abdon Pena-Francesch and Huihun Jung

      Article first published online: 4 DEC 2014 | DOI: 10.1002/mabi.201400324

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      This Feature Article highlights structural and functional characteristics of bio-derived materials, which will expedite the design, fabrication, and synthesis of eco-friendly, recyclable, advanced nano-materials and devices.

  6. Communications

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Feature Articles
    7. Communications
    8. Full Papers
    9. Correction
    1. Cell—Cell Crosslinking by Bio-Molecular Recognition of Heparin-Based Layer-by-Layer Nanofilms (pages 312–317)

      Akihiro Nishiguchi, Michiya Matsusaki and Mitsuru Akashi

      Article first published online: 9 JAN 2015 | DOI: 10.1002/mabi.201400415

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      Bio-molecular recognition between living cells and polymer nanofilms allows rapid cellular assembly to form cell aggregates. The aggregates display viscous properties and network structures crosslinked with polymer nanofilms. Specific inter-domain interactions between proteins and glycosaminoglycan cause cell–cell crosslinking. The assembly method supports in vitro 3D-tissue formation.

  7. Full Papers

    1. Top of page
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    3. Back Cover
    4. Masthead
    5. Contents
    6. Feature Articles
    7. Communications
    8. Full Papers
    9. Correction
    1. Semiconductor Polymer Dots Induce Proliferation in Human Gastric Mucosal and Adenocarcinoma Cells (pages 318–327)

      Shouying Li, Jia Chen, Geng Chen, Qiong Li, Kai Sun, Zhen Yuan, Weiping Qin, Hong Xu and Changfeng Wu

      Article first published online: 12 DEC 2014 | DOI: 10.1002/mabi.201400428

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      Highly fluorescent polymer dots induce apparent proliferation in human gastric mucosal and adenocarcinoma cells, as validated by MTT viability studies, cell cycle analysis, ROS generation, and MMP changes. The Pdot-induced cell proliferation represents a distinctive finding as most of other nanoparticles interacted with cells typically cause cell damage and inhibit cell growth.

    2. Micellization of Antineoplastic Agent to Significantly Upregulate Efficacy and Security (pages 328–341)

      Chen Li, Weiguo Xu, Jianxun Ding, Ying Zhang, Jincheng Wang, Xiuli Zhuang and Xuesi Chen

      Article first published online: 7 NOV 2014 | DOI: 10.1002/mabi.201400356

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      Doxorubicin-incorporated micelle is prepared by noncovalent interaction-assisted nanoprecipitation of drug and methoxy poly(ethylene glycol)-block-oligo(D,L-leucine). The loading micelle exhibits enhanced cellular interalization and antiproliferative activity in vitro, improved intratumoral distribution, and upregulated antitumor efficacy and security in vivo, which all indicate its great potential for smart delivery of antineoplastic agents.

    3. Poly(anhydride-ester) and Poly(N-vinyl-2-pyrrolidone) Blends: Salicylic Acid-Releasing Blends with Hydrogel-Like Properties that Reduce Inflammation (pages 342–350)

      Michelle A. Ouimet, Renata Fogaça, Sabrina S. Snyder, Sameer Sathaye, Luiz H. Catalani, Darrin J. Pochan and Kathryn E. Uhrich

      Article first published online: 21 OCT 2014 | DOI: 10.1002/mabi.201400238

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      Hydrogels-like polymer blends that combine the biocompatibility and hydrophilicity of PVP with controlled release of salicylic acid to reduce inflammation are presented. These copolymer blends substantially reduce the inflammatory cytokine, TNF-α, in vitro and indicate no cytotoxic or anti-proliferative effects. Based upon the unique combination, these blended polymer films show great potential for wound healing.

    4. Degradable Glycine-Based Photo-Polymerizable Polyphosphazenes for Use as Scaffolds for Tissue Regeneration (pages 351–363)

      Sandra Rothemund, Tamara B. Aigner, Aitziber Iturmendi, Maria Rigau, Branislav Husár, Florian Hildner, Eleni Oberbauer, Martina Prambauer, Gbenga Olawale, Reinhard Forstner, Robert Liska, Klaus R. Schröder, Oliver Brüggemann and Ian Teasdale

      Article first published online: 30 OCT 2014 | DOI: 10.1002/mabi.201400390

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      Hydrolytically degradable, porous matrices are prepared via a mild and simple photopolymerization of functionalized poly(organo)phosphazenes. The modular system allows facile surface functionalization and property tuning. The novel materials are biocompatible and have tunable degradation rates to non-toxic small molecules and thus are promising for use as synthetic scaffolds for tissue regeneration.

    5. Substrate-induced PC12 Cell Differentiation Without Filopodial, Lamellipodial Activity or NGF Stimulationa (pages 364–371)

      Guillaume Lamour, Sylvie Souès and Ahmed Hamraoui

      Article first published online: 28 OCT 2014 | DOI: 10.1002/mabi.201400323

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      PC12 cells are driven to extend neurites through cell-substrate interactions only, that is, without nerve growth factor (NGF) stimulation. Actin polymerization is destabilized by treating the cells with cytochalasin. As a result the cells are deprived of both filopodia and lamellipodia. However, they extend neurites continuously. This shows that neither filopodia nor lamellipodia are required to trigger substrate-induced neuronal differentiation of PC12 cells.

    6. Effect of Amphiphilic PCL–PEG Nano-Micelles on HepG2 Cell Migration (pages 372–384)

      Yang Shen, Mengtian Leng, Hongchi Yu, Qin Zhang, Xianglin Luo, Hans Gregersen, Guixue Wang and Xiaoheng Liu

      Article first published online: 4 NOV 2014 | DOI: 10.1002/mabi.201400376

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      Nano-sized polymer micelles attract attentions to their biocompatibility and biodegradability in antitumor therapy. However, few investigations focus on exploring the effect of internalized nano-micelles on the cancer cells migration. It is demonstrated that amphiphilic PCL–PEG NPs-induced cell migration depended on integrin-FAK-Rho GTPases pathway, which expected to evoke more attentions in the design of drug delivery systems based on polymer micelles.

    7. Diblock Copolymers of Polyethylene Glycol and a Polymethacrylamide with Side-Chains Containing Twin Ortho Ester Rings: Synthesis, Characterization, and Evaluation as Potential pH-Responsive Micelles (pages 385–394)

      Xiaojing Zhou, Shi Luo, Rupei Tang, Rui Wang and Jun Wang

      Article first published online: 5 NOV 2014 | DOI: 10.1002/mabi.201400395

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      Block copolymers, PEG-b-PMEA, bearing twin five-membered ortho ester pendants, form micelles with pH-responsive solubility as a result of accelerated release of payload. The micelles are compatible with cells, and paclitaxel-loaded micelles killed cancer cells with potency equivalent to free drug, suggesting potential use as effective nano-carriers for anticancer drugs without toxic side-effects.

    8. Targeted Delivery of Vaccine to Dendritic Cells by Chitosan Nanoparticles Conjugated with a Targeting Peptide Ligand Selected by Phage Display Technique (pages 395–404)

      Su-Na Jung, Sang-Kee Kang, Guen-Hye Yeo, Hai-Ying Li, Tao Jiang, Jae-Woon Nah, Jin-Duck Bok, Chong-Su Cho and Yun-Jaie Choi

      Article first published online: 13 NOV 2014 | DOI: 10.1002/mabi.201400352

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      Delivering antigen to dendritic cells (DCs) is a promising strategy for enhancing vaccine efficacy. A novel DC-targeting peptide ligand is isolated by phage display technique. DC-targeting peptide conjugated chitosan nanoparticles (TPC-NPs) are designed and evaluated for their targeting efficiency to DCs. Furthermore, immunization of mice with antigen-carrying TPC-NPs induces strong and balanced immune responses, demonstrating that TPC-NPs can further improve the immunogenicity of vaccine.

    9. Protein Compatibility of Selected Cross-linking Reactions for Hydrogels (pages 405–413)

      Nadine Hammer, Ferdinand P. Brandl, Susanne Kirchhof, Viktoria Messmann and Achim M. Goepferich

      Article first published online: 14 NOV 2014 | DOI: 10.1002/mabi.201400379

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      Despite years of research, finding cross-linking reactions for hydrogels that are compatible with incorporated proteins is still challenging. The authors, therefore, investigate side reactions between a model protein and methoxypolyethylene glycol functionalized with maleimide, vinyl sulfone, acrylamide, thiol, and furyl moieties. The extent of protein modification is found to depend on the cross-linking agent and the pH during incubation.

    10. A Cationic Poly(2-oxazoline) with High In Vitro Transfection Efficiency Identified by a Library Approach (pages 414–425)

      Alexandra C. Rinkenauer, Lutz Tauhardt, Felix Wendler, Kristian Kempe, Michael Gottschaldt, Anja Traeger and Ulrich S. Schubert

      Article first published online: 18 NOV 2014 | DOI: 10.1002/mabi.201400334

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      An 18-membered library of cationic poly(2-oxazoline)-based copolymers is prepared. The influence of different polymer parameters, namely the polymer side chain hydrophobicity and the type and content of amino groups, on the pDNA condensation, the transfection efficiency, the cytotoxicity, and cellular membrane interaction as well as the size, charge, and stability of the polyplexes is studied and first structure–property relationships elucidated.

    11. Engineering a Freestanding Biomimetic Cardiac Patch Using Biodegradable Poly(lactic-co-glycolic acid) (PLGA) and Human Embryonic Stem Cell-derived Ventricular Cardiomyocytes (hESC-VCMs) (pages 426–436)

      Yin Chen, Junping Wang, Bo Shen, Camie W. Y. Chan, Chaoyi Wang, Yihua Zhao, Ho N. Chan, Qian Tian, Yangfan Chen, Chunlei Yao, I-Ming Hsing, Ronald A. Li and Hongkai Wu

      Article first published online: 25 NOV 2014 | DOI: 10.1002/mabi.201400448

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      A facile method for engineering a freestanding biomimetic cardiac patch using biodegradable poly(lactic-co-glycolic acid) (PLGA) and stem cell-derived cardiomyocytes is presented. The biomimetic cardiac patch fabricated with microgrooved PLGA film recapitulates the anisotropic electrophysiological feature of native cardiac tissue and is believed to be applicable in the treatment of myocardial infarction.

  8. Correction

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Feature Articles
    7. Communications
    8. Full Papers
    9. Correction
    1. You have free access to this content
      Viability of Human Mesenchymal Stem Cells Seeded on Crosslinked Entropy-Elastic Gelatin-Based Hydrogels (page 437)

      Benjamin F. Pierce, Erik Pittermann, Nan Ma, Tim Gebauer, Axel T. Neffe, Magdalena Hölscher, Friedrich Jung and Andreas Lendlein

      Article first published online: 3 MAR 2015 | DOI: 10.1002/mabi.201500017

      This article corrects:

      Viability of Human Mesenchymal Stem Cells Seeded on Crosslinked Entropy-Elastic Gelatin-Based Hydrogels

      Vol. 12, Issue 3, 312–321, Article first published online: 7 FEB 2012

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