Novel Linear Polymers Able to Inhibit Bacterial Quorum Sensing (pages 647–656)
Eliana Cavaleiro PhD, Ana Sofia Duarte PhD, Ana Cristina Esteves PhD, António Correia PhD, Michael J. WhitcombePhD, Elena V. Piletska PhD, Sergey A. Piletsky PhD and Iva Chianella PhD
Article first published online: 28 JAN 2015 | DOI: 10.1002/mabi.201400447
The conventional treatment of bacterial infections is based on the administration of antibiotics, which promotes bacterial resistance. The development of linear polymers able to disrupt quorum sensing is presented, as shown by the reduction of bacterial bioluminescence and biofilm formation. The polymers an be used to control bacterial virulence without promoting resistance, thus constituting a safe alternative to the use of antibiotics.