Heparin-Based Nanocapsules as Potential Drug Delivery Systems (pages 765–776)
Grit Baier, Svenja Winzen, Claudia Messerschmidt, Daniela Frank, Michael Fichter, Stephan Gehring, Volker Mailänder and Katharina Landfester
Article first published online: 12 MAR 2015 | DOI: 10.1002/mabi.201500035
Low toxic, narrowly distributed heparin-based nanocapsules are synthesized via a miniemulsion polymerization. Microscopy, zeta potential values, isothermal titration calorimetry, dynamic light scattering, and activated clotting time measurements demonstrate the morphology and biological intactness of the polymeric shell. This is confirmed by an impressive uptake in different cells, monitored by fluorescence activated cell sorting, confocal laser scanning, and transmission electron microscopy.