Cathepsin B Imaging to Predict Quality of Engineered Cartilage (pages 1224–1232)
Ji Young Yhee, Yong-Jin Kim, Ju Hee Ryu, Hong Yeol Yoon, Hyeyoun Chang, Jae Hyung Park, Hyukjin Lee, Hyon-Seok Jang, Unyong Jeong, Kwangmeyung Kim and Sun-Woong Kang
Article first published online: 14 JUL 2015 | DOI: 10.1002/mabi.201500215
Cathepsin B (CB)-specific molecular imaging probe is applied to monitor the changes of CB expression in 3D cultured chondrocytes. The CB activities in two different sets of chondrocytes are comparatively analyzed using the probe, and CB molecular imaging can provide a reliable prediction for the quality of engineered cartilage in re-differentiating chondrocytes, during the formation of new cartilage tissue.