Macromolecular Bioscience

Cover image for Vol. 15 Issue 9

September 2015

Volume 15, Issue 9

Pages 1175–1322

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Review
    7. Communications
    8. Frontispiece
    9. Communications
    10. Full Papers
    1. Cover Picture: Macromol. Biosci. 9/2015 (page 1175)

      Seog-Jin Seo, Seon-Young Lee, Seong-Jun Choi and Hae-Won Kim

      Article first published online: 2 SEP 2015 | DOI: 10.1002/mabi.201570029

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      Front Cover: Our multifunctional nanocarrier system designed for tumor-targeting co-delivery shows controlled release behaviors of hydrophobic molecules at tumors by a temperature trigger and receptor-mediated gene delivery. In this system, functions of temperature-sensitive drug release and tumor's specific receptor-mediated gene delivery originate from Pluronic F127 and polyethylenimine-decorated folic acid, respectively. Thus, this system envisages a promising potential for the cancer treatment in response to hitting temperature to hyperthermia. Further details can be found in the article by S.-J. Seo et al. on page 1198.

  2. Back Cover

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Review
    7. Communications
    8. Frontispiece
    9. Communications
    10. Full Papers
    1. Back Cover: Macromol. Biosci. 9/2015 (page 1324)

      Werner E. G. Müller, Emad Tolba, Heinz C. Schröder and Xiaohong Wang

      Article first published online: 2 SEP 2015 | DOI: 10.1002/mabi.201570033

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      Back Cover: Polyphosphate (PolyP), if encapsulated into nanoparticles, is engulfed by the target cells. In response, the gene encoding the alkaline phosphatase (ALP) is abundantly expressed and the enzyme is then translocated to the surface of the cells. Further details can be found in the article by W. E. G. Müller et al. on page 1182.

  3. Masthead

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Review
    7. Communications
    8. Frontispiece
    9. Communications
    10. Full Papers
    1. Masthead: Macromol. Biosci. 9/2015 (page 1176)

      Article first published online: 2 SEP 2015 | DOI: 10.1002/mabi.201570030

  4. Contents

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Review
    7. Communications
    8. Frontispiece
    9. Communications
    10. Full Papers
    1. Contents: Macromol. Biosci. 9/2015 (pages 1177–1181)

      Article first published online: 2 SEP 2015 | DOI: 10.1002/mabi.201570031

  5. Review

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Review
    7. Communications
    8. Frontispiece
    9. Communications
    10. Full Papers
    1. You have free access to this content
      Polyphosphate: A Morphogenetically Active Implant Material Serving as Metabolic Fuel for Bone Regeneration (pages 1182–1197)

      Werner E. G. Müller, Emad Tolba, Heinz C. Schröder and Xiaohong Wang

      Article first published online: 15 MAY 2015 | DOI: 10.1002/mabi.201500100

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      Polyphosphate (polyP) is a natural inorganic polymer that is synthesized in cells in close vicinity of bone tissue. This polymer is biocompatible and bioresorbable. The characteristic features of polyP are the physiological origin and the huge conserved reservoir of metabolic energy. Since Ca-polyP is built of phosphate and Ca2+, it can be fabricated to bone scaffolds.

  6. Communications

    1. Top of page
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    3. Back Cover
    4. Masthead
    5. Contents
    6. Review
    7. Communications
    8. Frontispiece
    9. Communications
    10. Full Papers
    1. Tumor-Targeting Co-Delivery of Drug and Gene from Temperature-Triggered Micelles (pages 1198–1204)

      Seog-Jin Seo, Seon-Young Lee, Seong-Jun Choi and Hae-Won Kim

      Article first published online: 19 MAY 2015 | DOI: 10.1002/mabi.201500137

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      Our multifunctional nanocarrier system designed for tumor-targeting co-delivery shows controlled release behaviors of hydrophobic molecules at tumors by a temperature trigger and receptor-mediated gene delivery. The unique property of this system is demonstrated by a series of logical characterization measurements, which suggests that this system has a potential for the hyperthermia treatment.

  7. Frontispiece

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Review
    7. Communications
    8. Frontispiece
    9. Communications
    10. Full Papers
    1. Special Series Advanced Polymers in Stem Cell Biology & Medicine (page 1205)

      Donghwa Yun, Young M. Lee, Melissa R. Laughter, Curt R. Freed and Daewon Park

      Article first published online: 2 SEP 2015 | DOI: 10.1002/mabi.201570032

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      Frontispiece: A biomimetic polymer, made from repeating units consisting of GRGDS-conjugated urea, has been employed to enhance the differentiation and growth of human neural stem cells. Cells cultured on this polymer show an increase in axon extension and motor neuron expression showing promise for spinal cord injury treatment. Further details can be found in the article by D. Park et al. on page 1206.

  8. Communications

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    6. Review
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    1. Substantial Differentiation of Human Neural Stem Cells Into Motor Neurons on a Biomimetic Polyurea (pages 1206–1211)

      Donghwa Yun, Young M. Lee, Melissa R. Laughter, Curt R. Freed and Daewon Park

      Article first published online: 29 MAY 2015 | DOI: 10.1002/mabi.201500066

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      Human neural stem cells are successfully cultured and differentiated into motor neurons on a biomimetic polymer functionalized with RGD. Mature motor neurons are able to survive and proliferate efficiently on this synthetic coating demonstrating its potential to act as an implantable cell scaffold for spinal cord injury treatment.

    2. Curcumin Targeted, Polymalic Acid-Based MRI Contrast Agent for the Detection of Aβ Plaques in Alzheimer's Disease (pages 1212–1217)

      Rameshwar Patil, Pallavi R. Gangalum, Shawn Wagner, Jose Portilla-Arias, Hui Ding, Arthur Rekechenetskiy, Bindu Konda, Satoshi Inoue, Keith L. Black, Julia Y. Ljubimova and Eggehard Holler

      Article first published online: 2 JUN 2015 | DOI: 10.1002/mabi.201500062

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      Currently, there is no gadolinium-based contrast agent available for conventional magnetic resonance imaging (MRI) detection of amyloidal beta plaques in Alzheimer disease. We have designed a novel nanoimaging agent based on poly(β-l-malic acid) containing covalently attached curcumin and gadolinium–DOTA. This nanoimaging agent recognizes and selectively binds to Aβ plaques and is detectable by fluorescence and MRI.

    3. Synergistic Effects of SDF-1α and BMP-2 Delivery from Proteolytically Degradable Hyaluronic Acid Hydrogels for Bone Repair (pages 1218–1223)

      Julianne L. Holloway, Henry Ma, Reena Rai, Kurt D. Hankenson and Jason A. Burdick

      Article first published online: 8 JUN 2015 | DOI: 10.1002/mabi.201500178

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      The effect of dual delivery of SDF-1α and BMP-2 on in vivo bone repair is investigated, where biomolecule delivery is mediated via proteolytic hydrogel degradation. The delivery of SDF-1α in combination with BMP-2 results in improved in vivo osteogenesis and cell invasion and the effective BMP-2 dose for new bone repair is significantly reduced.

  9. Full Papers

    1. Top of page
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    4. Masthead
    5. Contents
    6. Review
    7. Communications
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    10. Full Papers
    1. Cathepsin B Imaging to Predict Quality of Engineered Cartilage (pages 1224–1232)

      Ji Young Yhee, Yong-Jin Kim, Ju Hee Ryu, Hong Yeol Yoon, Hyeyoun Chang, Jae Hyung Park, Hyukjin Lee, Hyon-Seok Jang, Unyong Jeong, Kwangmeyung Kim and Sun-Woong Kang

      Article first published online: 14 JUL 2015 | DOI: 10.1002/mabi.201500215

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      Cathepsin B (CB)-specific molecular imaging probe is applied to monitor the changes of CB expression in 3D cultured chondrocytes. The CB activities in two different sets of chondrocytes are comparatively analyzed using the probe, and CB molecular imaging can provide a reliable prediction for the quality of engineered cartilage in re-differentiating chondrocytes, during the formation of new cartilage tissue.

    2. Selective Cell Adhesion and Biosensing Applications of Bio-Active Block Copolymers Prepared by CuAAC/Thiol-ene Double Click Reactions (pages 1233–1241)

      Gizem Oyman Eyrilmez, Sean Doran, Eljesa Murtezi, Bilal Demir, Dilek Odaci Demirkol, Hakan Coskunol, Suna Timur and Yusuf Yagci

      Article first published online: 13 MAY 2015 | DOI: 10.1002/mabi.201500099

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      N-Acetyl-l-cysteine (NAC)-capped poly(methyl methacrylate)-b-polycaprolactone block copolymer (PMMA-b-PCL-NAC) is synthesized using one-pot photoinduced sequential CuAAC/thiol-ene double click procedure. The constructed surfaces within the modification of RGD peptide are used for the selective cell binding in the way of cell viability and electrochemical biosensing platform. Glioblastoma cells are found to be more selective to PMMA-b-PCL-NAC/RGD surface than HaCaT keratinocytes.

    3. Nanoparticle Formulation of AEA and BAEA Cellulose Carbamates Increases Biocompatibility and Antimicrobial Activity (pages 1242–1251)

      Cornelia Wiegand, Melanie Nikolajski, Uta-Christina Hipler and Thomas Heinze

      Article first published online: 15 MAY 2015 | DOI: 10.1002/mabi.201500031

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      Antimicrobially active polymers gain increasing interest in health care. AEA and BAEA cellulose carbamates exhibit a significant antimicrobial activity with moderate cell compatibility. Biocompatibility is enhanced by nanoparticle formulation. AEA cellulose carbamate NPs demonstrate a ratio of LC50/IC50 that is four to six times higher than that of BAEA cellulose carbamate NPs.

    4. Synergistically Improved Anti-tumor Efficacy by Co-delivery Doxorubicin and Curcumin Polymeric Micelles (pages 1252–1261)

      Jinling Wang, Wenzhuan Ma and Pengfei Tu

      Article first published online: 15 MAY 2015 | DOI: 10.1002/mabi.201500043

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      Co-encapsulated DOX and Cur micelles are designed to simultaneously deliver chemotherapeutic drug and multi-drug resistance (MDR) modulator to tumor sites. Co-delivery micelles exhibited excellent cytotoxicity, cellular uptake and cellular apoptosis in MCF7/Adr cells, and effective tumor inhibitory effects in 4T1-bearing mice. Therefore, co-encapsulated DOX and Cur micelles could be a promising vehicle for overcoming MDR and improving antitumor efficacy.

    5. Trivalent Cation Induced Bundle Formation of Filamentous fd Phages (pages 1262–1273)

      Nuriye Korkmaz Zirpel and Eun Jin Park

      Article first published online: 18 MAY 2015 | DOI: 10.1002/mabi.201500046

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      Aggregated bacteriophage bundles are obtained upon treatment of filamentous fd phages with trivalent counterions of varying ionic radii. Condensation of phages results in formation of either networking layer-like structures or denser intertwined agglomerated phage constructs. Self-assembly of molecular sub-units into functional assemblies in vivo and in vitro can be understood by studying polyelectrolyte properties of biomolecules like phages.

    6. Attachment of Poly(l-lactide) Nanoparticles to Plasma-Treated Non-Woven Polymer Fabrics Using Inkjet Printing (pages 1274–1282)

      Tatiana V. Ivanova, Grit Baier, Katharina Landfester, Eduard Musin, Sameer A. Al-Bataineh, David C. Cameron, Tomáš Homola, Jason D. Whittle and Mika Sillanpää

      Article first published online: 27 MAY 2015 | DOI: 10.1002/mabi.201500067

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      The integrated engineering solution is developed for the production of active wound dressings with poly(l-lactide) (PLLA) nanoparticles containing the antimicrobial agent octenidine and perylene dye on non-woven polymers. The process involves a surface pretreatment of the non-woven fabric using plasma jet and the immobilization of nanoparticles on non-woven polymer surfaces by using an inkjet printing process.

    7. Dendritic Glycopolymer as Drug Delivery System for Proteasome Inhibitor Bortezomib in a Calcium Phosphate Bone Cement: First Steps Toward a Local Therapy of Osteolytic Bone Lesions (pages 1283–1295)

      Christin Striegler, Matthias Schumacher, Christiane Effenberg, Martin Müller, Anja Seckinger, Reinhard Schnettler, Brigitte Voit, Dirk Hose, Michael Gelinsky and Dietmar Appelhans

      Article first published online: 28 MAY 2015 | DOI: 10.1002/mabi.201500085

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      Maltose-containing drug delivery systems (DDS) for complexation of the boronic acid containing proteasome inhibitor bortezomib are suitable for application in calcium phosphate bone cements. Release of bortezomib from specific DDS/bone cement composites is retarded in comparison to that of cements, loaded directly with the drug.

    8. The Relationship Between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues (pages 1296–1303)

      Kazuhiro Sato, Shingo Kobayashi, Miho Kusakari, Shogo Watahiki, Masahiko Oikawa, Takashi Hoshiba and Masaru Tanaka

      Article first published online: 28 MAY 2015 | DOI: 10.1002/mabi.201500078

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      The antithrombogenic property of PMEA analogues is studied, paying special attention to the hydration water structure of the polymers. The amount of adsorbed bovine serum albumin and the exposure degree of platelet adhesion sites for fibrinogen shows a decreasing trend with increasing the amount of freezing-bound water (intermediate water), and thus platelet adhesion is suppressed on PMEA analogues.

    9. Protein-Resistant Biodegradable Amphiphilic Graft Copolymer Vesicles as Protein Carriers (pages 1304–1313)

      Yupeng Wang, Lesan Yan, Bin Li, Yanxin Qi, Zhigang Xie, Xiabin Jing, Xuesi Chen and Yubin Huang

      Article first published online: 2 JUN 2015 | DOI: 10.1002/mabi.201500096

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      With enhanced resistance to protein adsorption, amphiphilic graft copolymers can self-assemble into vesicles in aqueous solutions, and entrap biomacromolecules (like hemoglobin) in the internal cavity. Meanwhile, they show lower permeability for water-soluble molecules compared with their block copolymer counterparts, providing a favorable platform as a hemoglobin delivery system for blood transfusion therapy.

    10. Dual Stimuli-Responsive Poly(β-amino ester) Nanoparticles for On-Demand Burst Release (pages 1314–1322)

      Jung Seok Lee, Xiaojian Deng, Patrick Han and Jianjun Cheng

      Article first published online: 2 JUN 2015 | DOI: 10.1002/mabi.201500111

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      Disassembly of poly(β-amino esters) nanoparticles is triggered by UV irradiation or change of solution pH for controlled burst release of payloads. The turbid suspension of the nanoparticles becomes clear upon induction of UV or pH stimuli, indicating particle dissolution into water.

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