Macromolecular Bioscience

Cover image for Vol. 16 Issue 2

February 2016

Volume 16, Issue 2

Pages 169–299

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Communications
    6. Full Papers
    7. Frontispiece
    8. Full Papers
    9. Correction
    1. You have free access to this content
      Cover Picture: Macromol. Biosci. 2/2016 (page 169)

      Ching-Yi Chen, Chao-Kai Syu and Hsin Chang Lin

      Article first published online: 10 FEB 2016 | DOI: 10.1002/mabi.201670007

      Thumbnail image of graphical abstract

      Front Cover: A pH-responsive mixed micelle system with photosensitizer-centered was developed for chemo-photodynamic therapy. This mixed micelle system with a precisely controlled release rate, dualmodality therapy, and passive tumor targeting ability has been demonstrated to improve in vitro cytotoxicity. Further details can be found in the article by C.-Y. Chen, C.-K. Syu and H. C. Lin on page 188.

  2. Masthead

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Communications
    6. Full Papers
    7. Frontispiece
    8. Full Papers
    9. Correction
    1. Masthead: Macromol. Biosci. 2/2016 (page 170)

      Article first published online: 10 FEB 2016 | DOI: 10.1002/mabi.201670008

  3. Contents

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Communications
    6. Full Papers
    7. Frontispiece
    8. Full Papers
    9. Correction
    1. Contents: Macromol. Biosci. 2/2016 (pages 171–174)

      Article first published online: 10 FEB 2016 | DOI: 10.1002/mabi.201670009

  4. Communications

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Communications
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    7. Frontispiece
    8. Full Papers
    9. Correction
    1. Acidity-Induced Destabilization of Nano-Sized Supramolecular Linear-Hyperbranched Polymersome for Controlled Release of Encapsulated Cargoes (pages 175–181)

      Xing Dong, Bin Yang, Hui-zhen Jia, Jing-yi Zhu, Ren-xi Zhuo, Jun Feng and Xian-zheng Zhang

      Article first published online: 7 OCT 2015 | DOI: 10.1002/mabi.201500298

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      A linear-hyperbranched supramolecular amphiphile is designed. The host-guest interaction in the amphiphilic construction allows not only control over assembly types (solid and hollow nanoparticles), but also the one-step accomplishment of both polymersome fabrication and drug encapsulation. The vesicles can release the encapsulated hydrophilic agents in an acidity-accelerated manner.

    2. Cellularized Cellular Solids via Freeze-Casting (pages 182–187)

      Sarah Christoph, Julien Kwiatoszynski, Thibaud Coradin and Francisco M. Fernandes

      Article first published online: 4 NOV 2015 | DOI: 10.1002/mabi.201500319

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      The elaboration of metabolically active cell-containing materials is a decisive step toward the successful application of cell based technologies. The present work unveils a new process allowing to simultaneously encapsulate living cells and shaping cell-containing materials into solid-state macroporous foams with precisely controlled morphology using freeze casting.

  5. Full Papers

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Communications
    6. Full Papers
    7. Frontispiece
    8. Full Papers
    9. Correction
    1. A Stimulated Mixed Micelle System for In Vitro Study on Chemo-Photodynamic Therapy (pages 188–197)

      Ching-Yi Chen, Chao-Kai Syu and Hsin Chang Lin

      Article first published online: 8 OCT 2015 | DOI: 10.1002/mabi.201500269

      Thumbnail image of graphical abstract

      A stimulated mixed micelle system with photosensitizer-centered for encapsulation of doxorubicin was developed for chemo-photodynamic therapy. This mixed micelle system shows good stability, controlled release rate and high singlet oxygen generation efficiency. In vitro study demonstrates a higher cytotoxicity under light condition relative to individual single drug loaded micelle, indicating improved therapeutic efficiency due to combination therapy.

  6. Frontispiece

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Communications
    6. Full Papers
    7. Frontispiece
    8. Full Papers
    9. Correction
    1. Stiffness of Hydrogels Regulates Cellular Reprogramming Efficiency Through Mesenchymal-to-Epithelial Transition and Stemness Markers (page 198)

      Bogyu Choi, Kwang-Sook Park, Ji-Ho Kim, Kyoung-Won Ko, Jin-Su Kim, Dong Keun Han and Soo-Hong Lee

      Article first published online: 10 FEB 2016 | DOI: 10.1002/mabi.201670010

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      Frontispiece: Physical signals at the interface between cell and substrate can be used as a potent regulator to promote cell fate changes associated with reprogramming into pluripotent stem cells (iPSCs) via increased mesenchymalto- epithelial transition activity and stemness marker expression. This study can lead to effective and reproducible iPSC-production. Further details can be found in the article by B. Choi, K.-S. Park, J.-H. Kim, K.-W. Ko, J.-S. Kim, D. K. Han, S.-H. Lee on page 199.

  7. Full Papers

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Communications
    6. Full Papers
    7. Frontispiece
    8. Full Papers
    9. Correction
    1. Stiffness of Hydrogels Regulates Cellular Reprogramming Efficiency Through Mesenchymal-to-Epithelial Transition and Stemness Markers  (pages 199–206)

      Bogyu Choi, Kwang-Sook Park, Ji-Ho Kim, Kyoung-Won Ko, Jin-Su Kim, Dong Keun Han and Soo-Hong Lee

      Article first published online: 6 OCT 2015 | DOI: 10.1002/mabi.201500273

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      The stiffness of hydrogels can be used as a potent regulator to promote cell fate changes associated with reprogramming into induced pluripotent stem cells (iPSCs) via increased mesenchymal-to-epithelial transition activity and stem cell marker expression. This study can lead to effective and reproducible iPSC production and be applied to iPSC-based therapy.

    2. Synthesis and Enzymatic Degradation of Soft Aliphatic Polyesters (pages 207–213)

      Viola Buchholz, Seema Agarwal and Andreas Greiner

      Article first published online: 24 SEP 2015 | DOI: 10.1002/mabi.201500279

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      Synthesis of novel aliphatic enzymatically degradable polyesters with short side chains leads to variable features. The influence of the reduced crystallinity on thermal and mechanical properties, melting behavior and Young's modulus, is reported. The controllable degradation behavior in combination with the reduced brittleness offers new possible applications for aliphatic polyesters.

    3. Phenolic Acid-based Poly(anhydride-esters) as Antioxidant Biomaterials (pages 214–222)

      Almudena Prudencio, Jonathan J. Faig, MinJung Song and Kathryn E. Uhrich

      Article first published online: 1 OCT 2015 | DOI: 10.1002/mabi.201500244

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      Naturally occurring, antioxidant-based poly(anhydride-esters) are synthesized in high yields via solution polymerization methods. Structures of precursor and polymer are determined and verified by NMR and Fourier transform IR spectroscopies. The polymers exhibit sustained hydrolytic release of phenolic acids over the 30 day study, maintaining antioxidant potency when compared to free bioactives.

    4. Synthesis of Amphiphilic Hyperbranched AIE-active Fluorescent Organic Nanoparticles and Their Application in Biological Application (pages 223–230)

      Qiulan Lv, Ke Wang, Dazhuang Xu, Meiying Liu, Qing Wan, Hongye Huang, Shangdong Liang, Xiaoyong Zhang and Yen Wei

      Article first published online: 16 SEP 2015 | DOI: 10.1002/mabi.201500256

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      A facile and effective strategy has been reported for fabrication of AIE-active nanoprobes trough one-step Michael addition reaction.

    5. Production of Immunoabsorbent Nanoparticles by Displaying Single-Domain Protein A on Potato Virus X (pages 231–241)

      Kerstin Uhde-Holzem, Michael McBurney, Brylee David B. Tiu, Rigoberto C. Advincula, Rainer Fischer, Ulrich Commandeur and Nicole F. Steinmetz

      Article first published online: 6 OCT 2015 | DOI: 10.1002/mabi.201500280

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      The in planta nanomanufacturing of immunosorbent, high aspect ratio nanoparticles for orientationally controlled antibody display is reported. A potato virus X-based nanofilaments with genetically introduced protein A fragments is produced and a antibody capture for biosensing applications is demonstrated.

    6. Layer-by-Layers of Polymeric Micelles as a Biomimetic Drug-Releasing Network (pages 242–254)

      Sundar P. Authimoolam, Andrew L. Lakes, David A. Puleo and Thomas D. Dziubla

      Article first published online: 29 SEP 2015 | DOI: 10.1002/mabi.201500310

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      Filomicelle networks possess high biomimetic relevance to natural mucin. The synthetic networks are evaluated for its ability to function as drug-releasing network. In developing a tunable release, dense barrier is deposited atop networks, and critically evaluated for its drug release and chemical stability. These tunable networks can potentially serve as a functional coat rendering localized delivery.

    7. Tailored Fringed Platforms Produced by Laser Interference for Aligned Neural Cell Growth (pages 255–265)

      Ramón J. Peláez, Ankor González-Mayorga, María C. Gutiérrez, Concepción García-Rama, Carmen N. Afonso and María C. Serrano

      Article first published online: 6 OCT 2015 | DOI: 10.1002/mabi.201500253

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      Laser interferometry is as a versatile and easy-to-use technique to fabricate fringed patterns on thin partially reduced graphene oxide layers with interest for cell alignment. Neural cells grown on these platforms significantly align their neurites along the direction of the fringes and preserve high viability in culture for up to two weeks.

    8. Disruption of Amyloid Prion Protein Aggregates by Cationic Pyridylphenylene Dendrimers (pages 266–275)

      Svetlana A. Sorokina, Yulia Yu. Stroylova, Zinaida B. Shifrina and Vladimir I. Muronetz

      Article first published online: 7 OCT 2015 | DOI: 10.1002/mabi.201500268

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      Cationic pyridylphenylene dendrimers are able to disrupt amyloid protein aggregates, e.g., prion protein inclusion bodies (PrP IB). The incubation of PrP IB with the dendrimers leads to formation of stable PrP-dendrimer complexes and the amyloid properties of PrP are decreased upon the interaction with the dendrimer.

    9. A Periosteum-Inspired 3D Hydrogel-Bioceramic Composite for Enhanced Bone Regeneration (pages 276–287)

      Yong Yao Chun, Jun Kit Wang, Nguan Soon Tan, Peggy Puk Yik Chan, Timothy Thatt Yang Tan and Cleo Choong

      Article first published online: 7 OCT 2015 | DOI: 10.1002/mabi.201500258

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      A hydrogel-bioceramic composite consisting of fish scale-derived CaP incorporated into a Gtn-HPA/CMC-Tyr hydrogel is demonstrated as a potential periosteum-inspired injectable system to enhance bone healing. The incorporation of CaP into the hydrogel significantly improves its mechanical properties, provides a bioactive environment for nucleation and formation of apatite, encourages cell proliferation, and shows a zero order FITC-dextran release profile.

    10. PolyDOPA Mussel-Inspired Coating as a Means for Hydroxyapatite Entrapment on Polytetrafluoroethylene Surface for Application in Periodontal Diseases (pages 288–298)

      Tiziana Nardo, Valeria Chiono, Gianluca Ciardelli and Maryam Tabrizian

      Article first published online: 7 OCT 2015 | DOI: 10.1002/mabi.201500241

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      This work gives a thorough characterization of non-resorbable polytetrafluoroethylene films, coated with hydroxyapatite nanoparticles (HAp) through an adhesive coating of self-polymerized 3,4-dihydroxy-DL-phenylalanine (polyDOPA). This coating technique represents an interesting approach able to improve MC3T3-E1 pre-osteoblastic cells adhesion and proliferation on polyDOPA/HAp-coated substrates.

  8. Correction

    1. Top of page
    2. Cover Picture
    3. Masthead
    4. Contents
    5. Communications
    6. Full Papers
    7. Frontispiece
    8. Full Papers
    9. Correction
    1. You have free access to this content
      Multifunctionalized CMCht/PAMAM Dendrimer Nanoparticles Modulate the Cellular Uptake by Astrocytes and Oligodendrocytes in Primary Cultures of Glial Cells (page 299)

      Susana R. Cerqueira, Bárbara L. Silva, Joaquim M. Oliveira, João F. Mano, Nuno Sousa, António J. Salgado and Rui L. Reis

      Article first published online: 10 FEB 2016 | DOI: 10.1002/mabi.201500419

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